公开(公告)号：US20100291070A1

公开(公告)日：2010-11-18

申请号：US12810459

申请日：2008-12-24

申请人： Masashi Kumagai ,  Jiro Tanaka ,  Hiroshi Nagaso ,  Tomohisa Ninomiya ,  Keiko Otsuka ,  Hirotomo Akabane ,  Takahisa Suzuki

发明人： Masashi Kumagai ,  Jiro Tanaka ,  Hiroshi Nagaso ,  Tomohisa Ninomiya ,  Keiko Otsuka ,  Hirotomo Akabane ,  Takahisa Suzuki

IPC分类号： A61K39/40 ,  C07K16/12 ,  C07K16/44 ,  C12N5/20 ,  A61K39/104 ,  A61K39/395 ,  A61P31/04 ,  A61P37/04

CPC分类号： C07K16/1214 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/21 ,  C07K2317/76 ,  G01N33/56911 ,  G01N2333/21

摘要： An object is to provide an antibody and a vaccine composition which have an ability to practically prevent or treat a Pseudomonas aeruginosa infection, and which can cope with the diversity of clinical isolates derived from patients infected with Pseudomonas aeruginosa. According to the present invention, an antibody against a PA1698 protein that is a type III secretion system component protein of Pseudomonas aeruginosa or against a peptide of the protein, and a vaccine composition comprising the protein or the peptide are provided.

摘要翻译： 目的是提供具有实际预防或治疗铜绿假单胞菌感染能力的抗体和疫苗组合物，其可以应付源自感染铜绿假单胞菌的患者的临床分离物的多样性。 根据本发明，提供了针对PA1698蛋白的抗体，其是铜绿假单胞菌的III型分泌系统组分蛋白或针对蛋白质的肽，以及包含所述蛋白质或肽的疫苗组合物。

公开(公告)号：US20100330100A1

公开(公告)日：2010-12-30

申请号：US12666805

申请日：2008-06-30

申请人： Jiro Tanaka ,  Hiroshi Nagaso ,  Masashi Kumagai ,  Keiko Otsuka ,  Hirotomo Akabane ,  Takahisa Suzuki

发明人： Jiro Tanaka ,  Hiroshi Nagaso ,  Masashi Kumagai ,  Keiko Otsuka ,  Hirotomo Akabane ,  Takahisa Suzuki

IPC分类号： A61K39/40 ,  C07K14/21 ,  C07K7/08 ,  C07K7/06 ,  C07K16/12 ,  C07K16/00 ,  C12N5/16 ,  A61K39/104 ,  A61P31/04

CPC分类号： C07K16/1214 ,  A61K39/104 ,  A61K2039/505 ,  C07K14/21 ,  C12Q1/04 ,  G01N33/569 ,  G01N2333/445

摘要： An object is to provide: a protein antigen or a peptide antigen usable as a vaccine composition which has an ability to practically prevent or treat a Pseudomonas aeruginosa infection, and which can cope with the diversity of clinical isolates derived from patients with a Pseudomonas aeruginosa infection; and an antibody directed against the antigen. The present invention provides a protein antigen or a peptide antigen and an antibody directed against these, which are for use in diagnosis, prevention, or treatment of a disease associated with Pseudomonas aeruginosa. According to the present invention, a protein or a peptide derived from a Pseudomonas aeruginosa-outer membrane protein PA4710, and an antibody directed against these are provided, which are for use in diagnosis, prevention, or treatment of a disease associated with Pseudomonas aeruginosa.

摘要翻译： 目的是提供：可用作疫苗组合物的蛋白质抗原或肽抗原，其具有实际预防或治疗绿脓假单胞菌感染的能力，并且其可以应对来自铜绿假单胞菌感染患者的临床分离物的多样性 ; 和针对抗原的抗体。 本发明提供蛋白质抗原或肽抗原和针对这些的抗原的抗体，其用于诊断，预防或治疗与铜绿假单胞菌相关的疾病。 根据本发明，提供了来自绿脓假单胞菌 - 外膜蛋白PA4710的蛋白质或肽，以及针对这些蛋白质的抗体，其用于诊断，预防或治疗与铜绿假单胞菌相关的疾病。

公开(公告)号：US20130004500A1

公开(公告)日：2013-01-03

申请号：US13579847

申请日：2011-02-18

申请人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

发明人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

IPC分类号： A61K39/40 ,  A61P31/04 ,  C07K16/12 ,  C12N15/13 ,  C12N5/16

CPC分类号： C07K16/1214 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/21

摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype A and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.

摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了与血清型A的铜绿假单胞菌菌株的LPS结合并且具有优异的体外和体内抗菌活性的抗体。

公开(公告)号：US20130045207A1

公开(公告)日：2013-02-21

申请号：US13579748

申请日：2011-02-18

申请人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

发明人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

IPC分类号： C07K16/12 ,  A61P31/04 ,  A61K39/40 ,  C12N5/12 ,  C12N15/13

CPC分类号： C07K16/1214 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/21

摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype G and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.

摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型G的铜绿假单胞菌菌株的体外和体内具有优异抗菌活性的LPS的抗体。

公开(公告)号：US20130022603A1

公开(公告)日：2013-01-24

申请号：US13579764

申请日：2011-02-18

申请人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

发明人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

IPC分类号： A61K39/40 ,  A61P31/04 ,  C12N5/16 ,  C07K16/12 ,  C12N15/13

CPC分类号： C07K16/1214 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/21

摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype I and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.

摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型I的铜绿假单胞菌菌株的LPS并在体外和体内具有优异抗菌活性的抗体。

公开(公告)号：US20130004499A1

公开(公告)日：2013-01-03

申请号：US13579757

申请日：2011-02-18

申请人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Jun Saito ,  Hiroshi Nagaso ,  Masashi Kumagai ,  Yasuyo Hagiwara

发明人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Jun Saito ,  Hiroshi Nagaso ,  Masashi Kumagai ,  Yasuyo Hagiwara

IPC分类号： C07K16/12 ,  C12N5/12 ,  A61P17/02 ,  A61P31/04 ,  A61P11/00 ,  C12N15/13 ,  A61K39/395

CPC分类号： C07K16/1214 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/21

摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype E and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.

摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型E的铜绿假单胞菌菌株的体外和体内具有优异抗菌活性的LPS的抗体。

公开(公告)号：US20130022604A1

公开(公告)日：2013-01-24

申请号：US13579826

申请日：2011-02-18

申请人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

发明人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

IPC分类号： A61K39/40 ,  A61P31/04 ,  C12N5/16 ,  C07K16/12 ,  C12N15/13

CPC分类号： C07K16/1214 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/21

摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype B and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.

摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型B的铜绿假单胞菌菌株的体外和体内具有优异抗菌活性的LPS的抗体。

公开(公告)号：US20090155279A1

公开(公告)日：2009-06-18

申请号：US12084205

申请日：2006-10-27

申请人： Jiro Tanaka ,  Fukuichi Ohsawa ,  Takafumi Okutomi ,  Hiroshi Nagaso ,  Masashi Kumagai ,  Takahisa Suzuki ,  Keiko Otsuka

发明人： Jiro Tanaka ,  Fukuichi Ohsawa ,  Takafumi Okutomi ,  Hiroshi Nagaso ,  Masashi Kumagai ,  Takahisa Suzuki ,  Keiko Otsuka

IPC分类号： A61K39/395 ,  C07K14/00 ,  A61K39/104 ,  C07K16/18 ,  C12N5/06

CPC分类号： C07K16/1214 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/52 ,  C07K14/21 ,  G01N33/56911

摘要： An object of the present invention is to provide a protein or peptide antigen and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa. According to the present invention, there is provided a protein or peptide derived from Pseudomonas aeruginosa outer membrane protein PA5158 and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa.

摘要翻译： 本发明的目的是提供蛋白质或肽抗原和抗体的抗体，用于诊断，预防或治疗与铜绿假单胞菌相关的疾病。 根据本发明，提供了来自绿脓假单胞菌外膜蛋白PA5158的蛋白质或肽，以及针对其的抗体，用于诊断，预防或治疗与铜绿假单胞菌相关的疾病。

公开(公告)号：US08084044B2

公开(公告)日：2011-12-27

申请号：US12225821

申请日：2007-03-30

申请人： Jiro Tanaka ,  Fukuichi Ohsawa ,  Takafumi Okutomi ,  Hiroshi Nagaso ,  Masashi Kumagai ,  Takahisa Suzuki ,  Keiko Otsuka

发明人： Jiro Tanaka ,  Fukuichi Ohsawa ,  Takafumi Okutomi ,  Hiroshi Nagaso ,  Masashi Kumagai ,  Takahisa Suzuki ,  Keiko Otsuka

IPC分类号： A61K39/108

CPC分类号： C07K16/1214 ,  C07K14/21 ,  C07K2317/77

摘要： An object of the present invention is to provide a protein or peptide antigen and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa. According to the present invention, there is provided a protein or peptide derived from Pseudomonas aeruginosa outer membrane protein PA0427 and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa.

摘要翻译： 本发明的目的是提供蛋白质或肽抗原和抗体的抗体，用于诊断，预防或治疗与铜绿假单胞菌相关的疾病。 根据本发明，提供了来自绿脓假单胞菌外膜蛋白PA0427的蛋白质或肽，以及用于诊断，预防或治疗与绿脓假单胞菌相关疾病的抗体。

公开(公告)号：US07824534B2

公开(公告)日：2010-11-02

申请号：US10588686

申请日：2005-12-09

申请人： Katsuyuki Tsuchida ,  Hironori Kobayashi ,  Masashi Kumagai

发明人： Katsuyuki Tsuchida ,  Hironori Kobayashi ,  Masashi Kumagai

IPC分类号： C25D3/38

CPC分类号： C25D1/04 ,  C25D3/38

摘要： The object of the present invention is to obtain a low profile electrolytic copper foil with a low surface roughness at the rough surface side (opposite side from the glossy side) in the electrolytic copper foil manufacture using a cathode drum and, particularly, to obtain an electrolytic copper foil with excellent elongation and tensile strength that permits fine patterning. Another object is to obtain a copper electrolytic solution that allows uniform copper plating without pinholes on a 2-layer flexible substrate. This copper electrolytic solution contains, as an additive, a compound having the specific skeleton represented by General Formula (1) below which is obtained by an addition reaction in which water is added to a compound having in a molecule one or more epoxy groups: wherein A is an epoxy compound residue and n is an integer of 1 or more.

摘要翻译： 本发明的目的是在使用阴极鼓的电解铜箔制造中，在粗糙表面侧（与光面相反的一侧）获得具有低表面粗糙度的薄型电解铜箔，特别是获得 电解铜箔具有优异的伸长率和拉伸强度，可以进行精细图案化。 另一个目的是获得一种铜电解溶液，其允许在2层柔性基板上均匀镀铜而没有针孔。 该铜电解液含有作为添加剂的具有下述通式（1）表示的特定骨架的化合物，其通过加成反应获得，其中将水加入到分子中具有一个或多个环氧基的化合物：其中 A是环氧化合物残基，n是1以上的整数。