专利检索 ap:"Tomoko Yashiro" 第 1 页

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发明授权
4'-Deoxy-3"-demethoxy-3"-methylenedesmycosin derivatives and synthetic intermediates thereof 失效
标题翻译： 4'-脱氧-3' - 脱甲氧基-3“ - 亚甲基二氢马来酸衍生物及其合成中间体

公开(公告)号：US4868290A

公开(公告)日：1989-09-19

申请号：US125155

申请日：1987-11-25

申请人： Tatsuro Fujiwara , Tomoko Yashiro , Hideo Sakakibara

发明人： Tatsuro Fujiwara , Tomoko Yashiro , Hideo Sakakibara

IPC分类号： A61K31/35 , A61P31/04 , C07H17/08

CPC分类号： C07H17/08 , Y02P20/55

摘要： 4"-deoxy-3"-demethoxy-3"-methylene-desmycosin derivatives of the formula ##STR1## wherein R.sub.1 is hydrogen, acyl or substituted carbamoyl,R.sub.2 is ##STR2## R.sub.3 is hydrogen or a protective group for hydroxy, R.sub.4 is hydrogen, hydroxy or protected hydroxy, and Me is --CH.sub.3, and pharmaceutically acceptable salts thereof are produced.These novel derivatives have antibiotic properties superior to the known related antibiotics tylosin and desmycosin.