公开(公告)号：US5516640A

公开(公告)日：1996-05-14

申请号：US229280

申请日：1994-04-18

申请人： Keisuke Watanabe ,  Toru Naraki ,  Yoshihiro Iwasaki

发明人： Keisuke Watanabe ,  Toru Naraki ,  Yoshihiro Iwasaki

IPC分类号： A61K39/395 ,  C12Q1/56 ,  G01N33/53 ,  G01N33/574 ,  G01N33/577 ,  G01N33/68 ,  G01N33/82 ,  G01N33/543 ,  G01N33/573

CPC分类号： G01N33/57438 ,  G01N33/68 ,  G01N33/82 ,  Y10S436/811

摘要： To provide a simple immunochemical assay of a PIVKA of every kind (PIVKA-VII, -IX, -X, -C, -S or -Z: protein induced by vitamin K absence) corresponding to a vitamin K-dependent protein. It has been confirmed that a PIVKA of every kind can be determined according to the double antibody sandwich method wherein use is made of a solid-supported anti-PIVKA-II monoclonal antibody. There is also disclosed a reagent for determination of a PIVKA of every kind according to the above-mentioned method.

摘要翻译： 提供对应于维生素K依赖性蛋白质的各种PIVKA（PIVKA-VII，-IX，-X，-C，-S或-Z：由维生素K缺乏诱导的蛋白质）的简单免疫化学测定。 已经确认，可以根据双固定夹心法测定各种PIVKA，其中使用固体负载的抗PIVKA-II单克隆抗体。 还公开了根据上述方法测定各种PIVKA的试剂。