公开(公告)号：US4076821A

公开(公告)日：1978-02-28

申请号：US662197

申请日：1976-02-27

申请人： Yoshinao Tsuda ,  Masafumi Arita ,  Toshio Hamasaki ,  Tatsumi Tsumagari ,  Takenori Kenjo

发明人： Yoshinao Tsuda ,  Masafumi Arita ,  Toshio Hamasaki ,  Tatsumi Tsumagari ,  Takenori Kenjo

IPC分类号： C07D471/10 ,  C07D401/04

CPC分类号： C07D471/10

摘要： 4,4-Diphenylcyclohexylpiperidine compounds and their analogs of the formula: ##STR1## wherein the dotted line in Ring A indicates an optional bond; R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently a hydrogen atom, a halogen atom, a trifluoromethyl group or a lower alkyl group; n is 1 or 2; m is 0 or 1; and Am is a piperidino group of the formula: ##STR2## where R.sup.5 and R.sup.6 are independently a hydrogen atom, a halogen atom, a trifluoromethyl group or a lower alkyl group, and the dotted line in Ring B indicates an optional bond;And pharmaceutically acceptable salts thereof are disclosed. They exhibit potent and long-lasting psychotropic effects.

摘要翻译： 4,4-二苯基环己基哌啶化合物及其类似物，其分子式如下：其中环A中的虚线表示任选的键; R1，R2，R3和R4独立地为氢原子，卤素原子，三氟甲基或低级烷基; n为1或2; m为0或1; 并且Am是下式的哌啶子基：其中R 5和R 6独立地是氢原子，卤素原子，三氟甲基或低级烷基，环B中的虚线表示 一个可选的债券; 并公布其药物可接受的费用。 它们表现出强大和持久的精神药效。

公开(公告)号：US4777151A

公开(公告)日：1988-10-11

申请号：US848482

申请日：1986-04-07

申请人： Keiichiro Koba ,  Akria Mathumoto ,  Yoshinori Koyanagi ,  Toshio Hamasaki ,  Katsuya Eguchi

发明人： Keiichiro Koba ,  Akria Mathumoto ,  Yoshinori Koyanagi ,  Toshio Hamasaki ,  Katsuya Eguchi

IPC分类号： C03B8/02 ,  C03B32/02 ,  C03C10/16

CPC分类号： C03C10/16 ,  C03B32/02

摘要： Disclosed is a glass-ceramic product having a chemical composition, as expressed in terms of oxides with the exception of F, in the weight range of 35 to 60% SiO.sub.2, 10 to 20% Al.sub.2 O.sub.3, 12 to 25% MgO, 5 to 15% K.sub.2 O and 4 to 15% F, containing no B.sub.2 O.sub.3, and containing 40 to 70% by weight of fluorophlogopite microcrystals. This glass-ceramic product has a flexural strength of not less than 1500 kgf/cm.sup.2, a heat resistance of about 1100.degree. C., excellent dielectric properties and good machinability, and is a material capable of extending the range of use of high performance ceramics.The aforesaid glass-ceramic product can be made by dissolving, in a solvent consisting essentially of a polar solvent, compounds (consisting largely of alkoxide compounds) of the metallic components and a fluorine compound in such proportions as to give a final product having the aforesaid chemical composition, hydrolyzing these compounds, dehydrating and drying the resulting gel, and heat-treating the resulting dry solid.

摘要翻译： 公开了一种玻璃陶瓷产品，其化学成分以除了F之外的氧化物表示，重量比为35至60％SiO 2，10至20％Al 2 O 3，12至25％MgO，5至15 ％K2O和4〜15％F，不含B2O3，含有40〜70％（重量）的荧锌矿微晶。 该玻璃陶瓷制品的弯曲强度为1500kgf / cm 2以上，耐热性为约1100℃，介电性能优良，切削性能好，是能够延长高性能陶瓷的使用范围的材料 。 上述玻璃陶瓷产品可以通过将基本上由极性溶剂，主要由醇盐化合物组成的化合物（主要由主要由烷氧基化合物组成）和氟化合物溶解在比例中而制成，从而得到具有上述 化学成分，水解这些化合物，脱水和干燥所得凝胶，并对所得干燥固体进行热处理。

公开(公告)号：US5198452A

公开(公告)日：1993-03-30

申请号：US728128

申请日：1991-07-10

申请人： Mitsuhiro Konishi ,  Minoru Kawakami ,  Michio Terasawa ,  Toshio Hamasaki

发明人： Mitsuhiro Konishi ,  Minoru Kawakami ,  Michio Terasawa ,  Toshio Hamasaki

IPC分类号： C07D213/30 ,  C07D213/32 ,  C07D213/40 ,  C07D215/12 ,  C07D215/22 ,  C07D215/233 ,  C07D401/12 ,  C07D405/12

CPC分类号： C07D213/30 ,  C07D213/32 ,  C07D213/40 ,  C07D215/12 ,  C07D215/233 ,  C07D401/12 ,  C07D405/12

摘要： A styryl compound of the formula(I): ##STR1## wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt or an ester thereof is disclosed.Since the compounds of the present invention possess potent and long-lasting leukotriene-antagonistic actions and inhibitory actions against leukotriene, and exhibit better absorption by the oral administration.Further, the compounds of the present invention possess 5-lipoxygenase-inhibitory actions and/or cyclooxygenase-inhibitory actions, inhibitory actions to biosynthesis of LTB4, chemotactic actions against human leucoccyte, chymase-inhibitory actions, inhibitory actions to release of histamine or antihistamine actions.Therefore, they are useful as the prophylactic and therapeutic medicines for brochial asthma, chronic bronchitis, atopic dermatitis, allergic rhinitis, allergic arthritis, allergic conjunctivitis, hay fever, urticaria, alimentary allergy, pain, pyretolysis, rheumatoid, thrombosis, coronary vascular diseases, ischemic heart disease, peptic or duodenal ulcer and the like.

摘要翻译： 公开了式（I）的苯乙烯基化合物：其中每个符号如说明书中所定义，其药学上可接受的盐或酯。 由于本发明的化合物具有强效的和持久的白三烯拮抗作用和对白细胞三烯的抑制作用，并且通过口服给药表现出更好的吸收。 此外，本发明的化合物具有5-脂氧合酶抑制作用和/或环加氧酶抑制作用，对LTB4的生物合成的抑制作用，对人类白细胞的趋化作用，糜酶抑制作用，释放组胺或抗组织胺作用的抑制作用 。 因此，它们可用作小儿哮喘，慢性支气管炎，特应性皮炎，过敏性鼻炎，过敏性关节炎，过敏性结膜炎，花粉症，荨麻疹，消化道变态反应，疼痛，并发症，类风湿，血栓形成，冠状动脉血管疾病等预防和治疗药物。 缺血性心脏病，消化性溃疡或十二指肠溃疡等。