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公开(公告)号：US20140148585A1
公开(公告)日：2014-05-29
申请号：US14129677
申请日：2012-06-28
IPC分类号： C07K14/47
CPC分类号： C07K14/4703 , C07K1/165 , C07K1/18 , C07K14/8128
摘要： The present invention relates to protein purification. More particularly, a method for directly recovering an objective protein from a protein composition and purifying a protein with a desired quality in a rapid and efficient manner is provided. Further, a rapid purification method capable of efficiently removing impurities included in the protein composition is provided. Therefore, compared to the conventional purification methods, quality and yield of the protein can be remarkably improved.
摘要翻译： 本发明涉及蛋白质纯化。 更具体地，提供了一种从蛋白质组合物中直接回收目标蛋白质并以快速且有效的方式纯化具有所需质量的蛋白质的方法。 此外，提供能够有效地除去蛋白质组合物中所含的杂质的快速纯化方法。 因此，与常规的纯化方法相比，可以显着提高蛋白质的质量和产率。
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公开(公告)号：USD548756S1
公开(公告)日：2007-08-14
申请号：US29250025
申请日：2006-10-31
申请人： Tsutomu Sugihara , Minori Yoshida
设计人： Tsutomu Sugihara , Minori Yoshida
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公开(公告)号：US09487566B2
公开(公告)日：2016-11-08
申请号：US14129677
申请日：2012-06-28
CPC分类号： C07K14/4703 , C07K1/165 , C07K1/18 , C07K14/8128
摘要： The present invention relates to protein purification. More particularly, a method for directly recovering an objective protein from a protein composition and purifying a protein with a desired quality in a rapid and efficient manner is provided. Further, a rapid purification method capable of efficiently removing impurities included in the protein composition is provided. Therefore, compared to the conventional purification methods, quality and yield of the protein can be remarkably improved.
摘要翻译： 本发明涉及蛋白质纯化。 更具体地，提供了一种从蛋白质组合物中直接回收目标蛋白质并以快速且有效的方式纯化具有所需质量的蛋白质的方法。 此外，提供能够有效地除去蛋白质组合物中所含的杂质的快速纯化方法。 因此，与常规的纯化方法相比，可以显着提高蛋白质的质量和产率。
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公开(公告)号：US6071220A
公开(公告)日：2000-06-06
申请号：US179838
申请日：1998-10-28
CPC分类号： B23Q3/15526 , B23Q3/155 , B23Q3/1576 , B23Q3/15773 , Y10T483/1748 , Y10T483/176 , Y10T483/1776
摘要： In the tool change device, a tool change arm 27 for changing a tool 25 with respect to a main spindle 24, a main tool magazine 29 including a plurality of hold grooves 30 arranged linearly for holding the tools 25, and a tool storage member 41 including at least one storage portion 46 for storing the tool 25 are arranged in the back-and-forth direction of the tool change device. In order that the tools 25 can be delivered between the tool change arm 27 and main tool magazine 29, between the main tool magazine 29 and tool storage member 41, and between the tool storage member 41 and tool change arm 27, a single tool loader L is disposed in such a manner that it can be moved in correspondence to the tool change arm 27, main tool magazine 29 and tool storage member 41.
摘要翻译： 在换刀装置中，具有用于相对于主轴24改变工具25的工具更换臂27，包括用于保持工具25直线布置的多个保持槽30的主工具仓29和工具存储部件41 包括用于存储工具25的至少一个存储部分46布置在换刀装置的前后方向上。 为了使工具25能够在工具更换臂27和主工具仓29之间，主工具仓29和工具存储构件41之间以及工具存储构件41和工具更换臂27之间传送，单个工具装载器 L以与工具更换臂27，主工具仓29和工具存放部件41对应的方式移动的方式配置。
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5.发明申请Machine Tool Having Linear Guide Device And Method For Exchanging Linear Guide 审中-公开具有直线导引装置的机床和交换线性导轨的方法公开(公告)号：US20090028657A1
公开(公告)日：2009-01-29
申请号：US11792480
申请日：2005-12-08
申请人： Shunichi Ishikawa , Masato Sugita , Kenji Matsushita , Takayoshi Torii , Koichi Sakal , Jiro Inoue , Tsutomu Sugihara
发明人： Shunichi Ishikawa , Masato Sugita , Kenji Matsushita , Takayoshi Torii , Koichi Sakal , Jiro Inoue , Tsutomu Sugihara
CPC分类号： B23Q1/017 , F16C29/004 , F16C29/02 , F16C2322/39 , Y10T409/307728 , Y10T483/10
摘要： The purpose of the present invention is to propose a machine tool having a linear guide device with new construction enabling exchange of a linear guide by easy work.With regard to a machine tool having linear guide devices 1 each of which has a base 11, guide rails 12 mounted on the base 11, linear guides 2 movably mounted on the guide rails 12, and jack-up mechanism comprising a saddle 9 (moving body) movably supported by the guide rails 12 through the linear guides and jack-up bolts 5 arranged between the base 11 and the saddle, the linear guides are fixed to the saddle through a fixing member, the fixation of the linear guides to the saddle is released by operating the fixing member, and gaps 8 are formed between the saddle and the linear guides by the jack-up mechanism arranged between the base and the saddle (moving body), whereby the linear guides can be exchanged.
摘要翻译： 本发明的目的是提出一种具有直线引导装置的机床，其具有能够通过简单工作来交换直线导轨的新结构。 对于具有直线导向装置1的机床1，其具有底座11，安装在基座11上的导轨12，可移动地安装在导轨12上的直线导轨2和包括鞍座9的自升式机构 主体）通过布置在基座11和鞍座之间的线性引导件和自升式螺栓5由导轨12可移动地支撑，线性引导件通过固定构件固定到鞍座上，将线性引导件固定到鞍座 通过操作固定构件来释放，并且通过设置在基座和鞍座（移动体）之间的自升式机构，在鞍座和线性导轨之间形成间隙8，从而可以更换直线导轨。
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公开(公告)号：US5885200A
公开(公告)日：1999-03-23
申请号：US837944
申请日：1997-04-28
申请人： Tsutomu Sugihara , Hisao Sasaki , Kazuoki Sakai
发明人： Tsutomu Sugihara , Hisao Sasaki , Kazuoki Sakai
CPC分类号： B23Q3/15526 , B23Q3/155 , B23Q3/1576 , B23Q3/15773 , Y10T483/1757 , Y10T483/176 , Y10T483/1771 , Y10T483/1776 , Y10T483/1855
摘要： In the tool change device, a tool change arm 27 for changing a tool 25 with respect to a main spindle 24, a main tool magazine 29 including a plurality of hold grooves 30 arranged linearly for holding the tools 25, and a tool storage member 41 including at least one storage portion 46 for storing the tool 25 are arranged in the back-and-forth direction of the tool change device. In order that the tools 25 can be delivered between the tool change arm 27 and main tool magazine 29, between the main tool magazine 29 and tool storage member 41, and between the tool storage member 41 and tool change arm 27, a single tool loader L is disposed in such a manner that it can be moved in correspondence to the tool change arm 27, main tool magazine 29 and tool storage member 41.
摘要翻译： 在换刀装置中，具有用于相对于主轴24改变工具25的工具更换臂27，包括用于保持工具25直线布置的多个保持槽30的主工具仓29和工具存储部件41 包括用于存储工具25的至少一个存储部分46布置在换刀装置的前后方向上。 为了使工具25能够在工具更换臂27和主工具仓29之间，主工具仓29和工具存储构件41之间以及工具存储构件41和工具更换臂27之间传送，单个工具装载器 L以与工具更换臂27，主工具仓29和工具存放部件41对应的方式移动的方式配置。
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公开(公告)号：US08076462B2
公开(公告)日：2011-12-13
申请号：US12594423
申请日：2008-04-02
IPC分类号： C07K14/47
CPC分类号： C07K14/8128 , A61K38/00
摘要： The provision of an antithrombin composition having a desired α-form content rate or β-form content rate is required. The invention provides a process for producing an antithrombin composition having a desired α-form content rate or β-form content rate which is prepared by contacting an antithrombin-containing aqueous solution with a Cellufine Sulfate chromatography carrier.
摘要翻译： 需要提供具有期望的α形式含量率或“形式含量”的抗凝血酶组合物。 本发明提供了通过使含抗凝血素的水溶液与硫酸纤维素色谱载体接触而制备具有所需的α-形式含量速率或“形式含量”的抗凝血酶组合物的方法。
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公开(公告)号：US20100113754A1
公开(公告)日：2010-05-06
申请号：US12594423
申请日：2008-04-02
IPC分类号： C07K14/47
CPC分类号： C07K14/8128 , A61K38/00
摘要： The provision of an antithrombin composition having a desired α-form content rate or β-form content rate is required. The invention provides a process for producing an antithrombin composition having a desired α-form content rate or β-form content rate which is prepared by contacting an antithrombin-containing aqueous solution with a Cellufine Sulfate chromatography carrier.
摘要翻译： 需要提供具有期望的α形式含量率或“形式含量”的抗凝血酶组合物。 本发明提供了通过使含抗凝血素的水溶液与硫酸纤维素色谱载体接触而制备具有所需的α-形式含量速率或“形式含量”的抗凝血酶组合物的方法。
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公开(公告)号：USD567263S1
公开(公告)日：2008-04-22
申请号：US29250024
申请日：2006-10-31
申请人： Tsutomu Sugihara , Minori Yoshida
设计人： Tsutomu Sugihara , Minori Yoshida
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公开(公告)号：US07182720B2
公开(公告)日：2007-02-27
申请号：US10760375
申请日：2004-01-21
CPC分类号： B23B39/161 , B23Q11/08 , B23Q11/085 , Y10S29/059 , Y10T408/89 , Y10T408/98 , Y10T409/30392 , Y10T483/115
摘要： A machine tool has a support table provided on an upper surface of a bed to support a work, a Z-axis saddle, a machining unit mounted on the Z-axis saddle and provided with a machining head, a compartment cover arranged on the bed to compartment a region and a machine region, an opening window provided on the compartment cover to permit the machining head to go in and out therethrough, and a seal member in the form of a closed ring to be mounted on an inner peripheral edge of the opening window of the compartment cover, wherein an entire periphery of an outer peripheral surface of the machining head is brought into sliding contact with an inner peripheral edge of the seal member in a state, in which the machining head is moved into the machining region from a tool exchange position within the machine region.
摘要翻译： 机床具有设置在床的上表面以支撑工件的支撑台，Z轴鞍座，安装在Z轴鞍座上并具有加工头的加工单元，设置在床上的隔室盖 以分隔区域和机器区域，设置在隔室盖上的开放窗口，以允许加工头进出通过;以及密封构件，其形式为闭环，以安装在所述密封环的内周边缘上 所述加热头的外周面的整个周边在所述加工头从所述加工区域移动到所述加工区域的状态下与所述密封构件的内周边缘滑动接触， 机器区域内的工具更换位置。
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