公开(公告)号：US20090036492A1

公开(公告)日：2009-02-05

申请号：US11990289

申请日：2006-08-08

申请人： Akihiro Furukawa ,  Jun Ohsumi ,  Tsuyoshi Arita ,  Takehiro Fukuzaki ,  Kazushi Araki ,  Makoto Mori ,  Takayuki Momose ,  Takeshi Honda ,  Masanori Kuroha ,  Ryo Okuyama ,  Susumu Satoh

发明人： Akihiro Furukawa ,  Jun Ohsumi ,  Tsuyoshi Arita ,  Takehiro Fukuzaki ,  Kazushi Araki ,  Makoto Mori ,  Takayuki Momose ,  Takeshi Honda ,  Masanori Kuroha ,  Ryo Okuyama ,  Susumu Satoh

IPC分类号： A61K31/443 ,  C07D307/91 ,  C07D405/12 ,  A61K31/343

CPC分类号： C07D307/91 ,  C07D405/12 ,  C07D407/12

摘要： The present invention relates to a novel cercosporamide derivative, a pharmacologically acceptable salt thereof or an ester thereof which has an excellent hypoglycemic effect and is useful as a therapeutic and/or prophylactic agent for diabetes.A cercosporamide derivative having the general formula (I): [wherein X represents an oxygen atom or the like, R1 represents a hydrogen atom or a C1-C6 alkyl group, R2 represents a hydrogen atom, a C1-C6 alkyl group or a C1-C6 halogenated alkyl group, R3 represents a hydrogen atom or a C1-C6 alkyl group, R4 represents a C6-C10 aryl group which may be substituted with one to five group(s) independently selected from Substituent Group a, or the like, n represents 1, 2 or 3, and Substituent Group a represents a halogen atom, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group, a C2-C6 alkenyl group, a C2-C6 alkynyl group, a C1-C6 alkoxy group, a C1-C6 halogenated alkoxy group, a C2-C6 alkenyloxy group, a C2-C6 alkynyloxy group and the like], a pharmacologically acceptable salt thereof or an ester thereof.

摘要翻译： 本发明涉及一种具有优异的降血糖作用，可用作糖尿病治疗和/或预防剂的新颖的孢子虫素衍生物，其药理学上可接受的盐或其酯。 具有通式（I）的孢孢酰胺衍生物：[其中X表示氧原子等，R 1表示氢原子或C 1 -C 6烷基，R 2表示氢原子，C 1 -C 6烷基或C 1 -C 6卤代烷基，R 3表示氢原子或C 1 -C 6烷基，R 4表示可以被一至五个独立地选自取代基组a的基团取代的C 6 -C 10芳基等， n表示1,2或3，取代基组a表示卤素原子，C1-C6烷基，C1-C6卤代烷基，C2-C6烯基，C2-C6炔基，C1-C6 烷氧基，C1-C6卤代烷氧基，C2-C6链烯氧基，C2-C6炔氧基等]，其药理学上可接受的盐或其酯。

公开(公告)号：US20110053933A1

公开(公告)日：2011-03-03

申请号：US12934506

申请日：2009-03-24

申请人： Kayoko Motoki ,  Kiichi Kawagoe ,  Shigeyuki Nishinaka ,  Sachie Masuda ,  Atsunobu Sakamoto ,  Satoru Kaneko ,  Tsuyoshi Arita ,  Aki Yokomizo

发明人： Kayoko Motoki ,  Kiichi Kawagoe ,  Shigeyuki Nishinaka ,  Sachie Masuda ,  Atsunobu Sakamoto ,  Satoru Kaneko ,  Tsuyoshi Arita ,  Aki Yokomizo

IPC分类号： A61K31/498 ,  C07D401/12 ,  C07D401/14 ,  A61K31/501 ,  C07D417/14 ,  A61K31/506 ,  C07D413/14 ,  A61K31/5377 ,  A61P7/02

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D417/14

摘要： The present invention provides a novel hydroxyquinoxaline carboxamide derivative that is useful for preventing and/or treating blood coagulation disorders. A compound represented by formula (i), or a pharmacologically acceptable salt thereof: wherein, each of R1 and R2 independently represents a group such as a hydrogen atom or a halogen atom; R3 represents a group such as a hydrogen atom; each of R4 and R5 independently represents a group such as a hydrogen atom, a halogen atom or a C1-4 alkyl group; each of R6 and R7 independently represents a hydrogen atom or a C1-4 alkyl group; X represents a group such as a C3-10 cycloalkyl group, C6-10 aryl group or a 5- to 10-membered heterocyclic group, which may be substituted with substituent(s) selected from substituent group α; Y represents a group such as —CO—, —O— or —NRa—, and Ra represents a group such as a hydrogen atom or a C1-4 alkyl group.

摘要翻译： 本发明提供了可用于预防和/或治疗凝血障碍的新型羟基喹喔啉羧酰胺衍生物。 式（i）表示的化合物或其药理学上可接受的盐：其中，R 1和R 2各自独立地表示氢原子或卤素原子等基团; R3表示氢原子等基团， R4和R5各自独立地表示氢原子，卤素原子或C1-4烷基等基团。 R6和R7各自独立地表示氢原子或C1-4烷基; X表示可以被选自取代基组α的取代基取代的C 10-10环烷基，C 6-10芳基或5〜10元杂环基等基团; Y表示-CO-，-O-或-NR a - ，R a表示氢原子或C 1-4烷基等基团。