公开(公告)号：US20090036492A1

公开(公告)日：2009-02-05

申请号：US11990289

申请日：2006-08-08

申请人： Akihiro Furukawa ,  Jun Ohsumi ,  Tsuyoshi Arita ,  Takehiro Fukuzaki ,  Kazushi Araki ,  Makoto Mori ,  Takayuki Momose ,  Takeshi Honda ,  Masanori Kuroha ,  Ryo Okuyama ,  Susumu Satoh

发明人： Akihiro Furukawa ,  Jun Ohsumi ,  Tsuyoshi Arita ,  Takehiro Fukuzaki ,  Kazushi Araki ,  Makoto Mori ,  Takayuki Momose ,  Takeshi Honda ,  Masanori Kuroha ,  Ryo Okuyama ,  Susumu Satoh

IPC分类号： A61K31/443 ,  C07D307/91 ,  C07D405/12 ,  A61K31/343

CPC分类号： C07D307/91 ,  C07D405/12 ,  C07D407/12

摘要： The present invention relates to a novel cercosporamide derivative, a pharmacologically acceptable salt thereof or an ester thereof which has an excellent hypoglycemic effect and is useful as a therapeutic and/or prophylactic agent for diabetes.A cercosporamide derivative having the general formula (I): [wherein X represents an oxygen atom or the like, R1 represents a hydrogen atom or a C1-C6 alkyl group, R2 represents a hydrogen atom, a C1-C6 alkyl group or a C1-C6 halogenated alkyl group, R3 represents a hydrogen atom or a C1-C6 alkyl group, R4 represents a C6-C10 aryl group which may be substituted with one to five group(s) independently selected from Substituent Group a, or the like, n represents 1, 2 or 3, and Substituent Group a represents a halogen atom, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group, a C2-C6 alkenyl group, a C2-C6 alkynyl group, a C1-C6 alkoxy group, a C1-C6 halogenated alkoxy group, a C2-C6 alkenyloxy group, a C2-C6 alkynyloxy group and the like], a pharmacologically acceptable salt thereof or an ester thereof.

摘要翻译： 本发明涉及一种具有优异的降血糖作用，可用作糖尿病治疗和/或预防剂的新颖的孢子虫素衍生物，其药理学上可接受的盐或其酯。 具有通式（I）的孢孢酰胺衍生物：[其中X表示氧原子等，R 1表示氢原子或C 1 -C 6烷基，R 2表示氢原子，C 1 -C 6烷基或C 1 -C 6卤代烷基，R 3表示氢原子或C 1 -C 6烷基，R 4表示可以被一至五个独立地选自取代基组a的基团取代的C 6 -C 10芳基等， n表示1,2或3，取代基组a表示卤素原子，C1-C6烷基，C1-C6卤代烷基，C2-C6烯基，C2-C6炔基，C1-C6 烷氧基，C1-C6卤代烷氧基，C2-C6链烯氧基，C2-C6炔氧基等]，其药理学上可接受的盐或其酯。

公开(公告)号：US08017610B2

公开(公告)日：2011-09-13

申请号：US12843348

申请日：2010-07-26

申请人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

发明人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

IPC分类号： A61K31/501 ,  A61K31/497 ,  A61K31/443 ,  A61K31/421 ,  C07D403/14 ,  C07D413/14 ,  C07D265/08

CPC分类号： C07D413/14 ,  C07D207/333 ,  C07D207/335 ,  C07D207/337 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14

摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].

摘要翻译： 本发明涉及具有优异的葡糖激酶活化活性的化合物或其药理学上可接受的盐，并且是通式（I）表示的化合物或其药理学上可接受的盐：[其中，A表示例如氧原子或 硫原子，R1表示例如C1-C6烷基，C1-C6烷氧基或C1-C6卤代烷基，A和R1与与其结合的碳原子一起形成可以被 1至3个独立地选自取代基组α的基团，R 2表示可以被独立地选自取代基组α的1至5个基团取代的苯基或可被1至3个基团取代的杂环基 独立地选自取代基组α，R3表示羟基或C1-C6烷氧基，取代基组α由例如卤素原子，C1-C6烷基，C1-C6烷基组成 取代 具有1或2个羟基，C1-C6烷基磺酰基和由式-V-NR5R6表示的基团（其中，V表示羰基或磺酰基，R5和R6可以相同） 或不同，分别表示氢原子或C1-C6烷基，或R5和R6与键合的氮原子一起形成可以被1或2个基团独立地取代的4至6元饱和杂环 选自C 1 -C 6烷基和羟基，并且4至6元饱和杂环可以进一步含有一个氧原子或氮原子）]。

公开(公告)号：US20110003787A1

公开(公告)日：2011-01-06

申请号：US12843348

申请日：2010-07-26

申请人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

发明人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

IPC分类号： A61K31/427 ,  C07D417/04 ,  C07D413/14 ,  C07D413/12 ,  A61P3/10 ,  A61K31/501 ,  A61K31/4439 ,  A61K31/428 ,  C07D403/04 ,  A61K31/497 ,  C07D207/34 ,  A61K31/40 ,  C07D413/04 ,  A61K31/422 ,  A61K31/5355 ,  C07D417/14 ,  A61K31/5377

CPC分类号： C07D413/14 ,  C07D207/333 ,  C07D207/335 ,  C07D207/337 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14

摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].

摘要翻译： 本发明涉及具有优异的葡糖激酶活化活性的化合物或其药理学上可接受的盐，并且是通式（I）表示的化合物或其药理学上可接受的盐：[其中，A表示例如氧原子或 硫原子，R1表示例如C1-C6烷基，C1-C6烷氧基或C1-C6卤代烷基，A和R1与与其结合的碳原子一起形成可以被 1至3个独立地选自取代基组α的基团，R 2表示可以被独立地选自取代基组α的1至5个基团取代的苯基或可被1至3个基团取代的杂环基 独立地选自取代基组α，R3表示羟基或C1-C6烷氧基，取代基组α由例如卤素原子，C1-C6烷基，C1-C6烷基组成 取代 具有1或2个羟基，C1-C6烷基磺酰基和由式-V-NR5R6表示的基团（其中，V表示羰基或磺酰基，R5和R6可以相同） 或不同，分别表示氢原子或C1-C6烷基，或R5和R6与键合的氮原子一起形成可以被1或2个基团独立地取代的4至6元饱和杂环 选自C 1 -C 6烷基和羟基，并且4至6元饱和杂环可以进一步含有一个氧原子或氮原子）]。

公开(公告)号：US08415359B2

公开(公告)日：2013-04-09

申请号：US13198819

申请日：2011-08-05

申请人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

发明人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

IPC分类号： A61K31/497 ,  A61K31/4439 ,  A61K31/443 ,  A61K31/428 ,  A61K31/427 ,  A61K31/421 ,  A61K31/4155 ,  A61K31/4025 ,  A61K31/40 ,  C07D401/14 ,  C07D401/12 ,  C07D413/04 ,  C07D413/14 ,  C07D277/62 ,  C07D277/20 ,  C07D263/08 ,  C07D263/30 ,  C07D403/04 ,  C07D403/14 ,  C07D207/323

CPC分类号： C07D413/14 ,  C07D207/333 ,  C07D207/335 ,  C07D207/337 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14

摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].

摘要翻译： 本发明涉及具有优异的葡糖激酶活化活性的化合物或其药理学上可接受的盐，并且是通式（I）表示的化合物或其药理学上可接受的盐：[其中，A表示例如氧原子或 硫原子，R1表示例如C1-C6烷基，C1-C6烷氧基或C1-C6卤代烷基，A和R1与与其结合的碳原子一起形成可以被 1至3个独立地选自取代基组α的基团，R 2表示可以被独立地选自取代基组α的1至5个基团取代的苯基或可被1至3个基团取代的杂环基 独立地选自取代基组α，R3表示羟基或C1-C6烷氧基，取代基组α由例如卤素原子，C1-C6烷基，C1-C6烷基组成 取代 具有1或2个羟基，C1-C6烷基磺酰基和由式-V-NR5R6表示的基团（其中，V表示羰基或磺酰基，R5和R6可以相同） 或不同，分别表示氢原子或C1-C6烷基，或R5和R6与键合的氮原子一起形成可以被1或2个基团独立地取代的4至6元饱和杂环 选自C 1 -C 6烷基和羟基，并且4至6元饱和杂环可以进一步含有一个氧原子或氮原子）]。

公开(公告)号：US20090137499A1

公开(公告)日：2009-05-28

申请号：US12280510

申请日：2007-08-03

申请人： Takeshi Honda ,  Minoru Oguchi ,  Masao Yoshida ,  Ryo Okuyama ,  Tsuneaki Ogata ,  Manabu Abe ,  Kenjiro Ueda ,  Jun Ohsumi ,  Masanori Izumi

发明人： Takeshi Honda ,  Minoru Oguchi ,  Masao Yoshida ,  Ryo Okuyama ,  Tsuneaki Ogata ,  Manabu Abe ,  Kenjiro Ueda ,  Jun Ohsumi ,  Masanori Izumi

IPC分类号： A61K31/706 ,  C07G3/00 ,  A61K31/7004 ,  C07H17/02

CPC分类号： C07H15/203 ,  A61K9/2018 ,  C07H17/02

摘要： The present invention relates to a benzylphenyl glucopyranoside derivative having an excellent inhibitory effect on human SGLT1 and/or SGLT2 activity. There is provided a compound or a pharmacologically acceptable salt thereof represented by the following general formula (I): wherein R1 represents a hydrogen atom, an amino group, a hydroxy C1-C6 alkyl group, etc.; R2 represents a hydrogen atom, etc.; R3 represents a C1-C6 alkyl group, a hydroxy C1-C6 alkyl group, etc.; R4 represents a hydrogen atom, a C2-C7 acyl group, etc.; R5, R6, R7, and R8 are the same or different and each represents a hydrogen atom or a C1-C6 alkyl group, provided that R5, R6, R7 and R8 are not hydrogen atoms at the same time; n is 0 to 4; and X is CH or N.

摘要翻译： 本发明涉及对人SGLT1和/或SGLT2活性具有优异抑制作用的苄基苯基吡喃葡萄糖苷衍生物。 提供由以下通式（I）表示的化合物或其药理学上可接受的盐：其中R1表示氢原子，氨基，羟基C1-C6烷基等; R2表示氢原子等; R3表示C1-C6烷基，羟基C1-C6烷基等; R4表示氢原子，C2-C7酰基等; R5，R6，R7和R8相同或不同，各自表示氢原子或C1-C6烷基，条件是R5，R6，R7和R8不同时为氢原子; n为0〜4; X为CH或N.

公开(公告)号：US09158108B2

公开(公告)日：2015-10-13

申请号：US13812895

申请日：2011-07-11

申请人： Takeshi Honda ,  Nobuaki Takanashi

发明人： Takeshi Honda ,  Nobuaki Takanashi

IPC分类号： G02B26/08 ,  G02B26/10 ,  H04N1/113

CPC分类号： G02B26/10 ,  G02B26/0858 ,  H04N1/113

摘要： An optical scanning device includes movable mirror (21) reflecting a light beam applied thereto, first beam (22) joined to an end of movable mirror (21), second beam (23) joined to another end of movable mirror (21), first piezoelectric element (11) generating stress or swinging movable mirror (21) through first beam (22), and second piezoelectric element (12) generating stress for swinging movable mirror (21) through first beam (22). First and second piezoelectric elements (11, 12) have respective patterns whose longitudinal directions are aligned with a longitudinal direction of first beam (11). First and second piezoelectric elements (11, 12) are disposed on a support plate (3) which is joined to the first and second beams (22 23) and with an insulative distance being present between first and second piezoelectric elements (11, 12).

摘要翻译： 光学扫描装置包括反射施加到其上的光束的可移动反射镜（21），与可动反射镜（21）的端部连接的第一光束（22），与可动反射镜（21）的另一端接合的第二光束（23） 通过第一梁（22）产生应力或摆动可移动镜（21）的压电元件（11）和通过第一梁（22）产生用于摆动可移动镜（21）的应力的第二压电元件（12）。 第一和第二压电元件（11,12）具有纵向与第一梁（11）的纵向对准的各自的图案。 第一和第二压电元件（11,12）设置在支撑板（3）上，支撑板（3）与第一和第二梁（22 23）接合并且在第一和第二压电元件（11,12）之间存在绝缘距离， 。

公开(公告)号：US20130266711A1

公开(公告)日：2013-10-10

申请号：US13818321

申请日：2011-08-24

申请人： Tomokazu Hara ,  Nao Takagi ,  Takeshi Honda ,  Azusa Endo ,  Toshihiro Omori

发明人： Tomokazu Hara ,  Nao Takagi ,  Takeshi Honda ,  Azusa Endo ,  Toshihiro Omori

IPC分类号： A23C9/14

CPC分类号： A23C9/14 ,  A23V2002/00 ,  A23V2200/254

摘要： The present invention provides a dairy beverage having an improved flavor without controlling the components of the dairy beverage. Disclosed is a dairy beverage which comprises fat components showing at least two peaks in the particle size distribution of fat particles. Also disclosed is a method for producing a dairy beverage, a method for improving flavor or a method for improving the dispersion properties of fat particles, each method comprising: (1) a step for microparticulating fat particles contained in raw milk to give a first raw milk which shows a peak in the particle size distribution of fat particles; (2) a step for microparticulating fat particles contained in raw milk to give a second raw milk which shows a peak in the particle size distribution of fat particles, said peak being different from the peak of the first raw milk; and (3) a step for blending the first raw milk with the second raw milk.

摘要翻译： 本发明提供一种具有改善风味的乳制品饮料，而不控制乳制品饮料的组分。 本发明提供一种乳饮料，其包含表示脂肪粒子的粒径分布的至少两个峰脂肪组分。 还公开了一种生产乳饮料的方法，改善风味的方法或改善脂肪颗粒的分散性能的方法，每种方法包括：（1）使生奶中所含的脂肪颗粒微粒化以产生第一原料 在脂肪颗粒的粒度分布中显示出峰值的牛奶; （2）使生奶中含有的脂肪粒子微粒化的步骤，得到显示脂肪粒子的粒度分布峰值的第二生奶，所述峰与第一生奶的峰不同; 和（3）将第一生牛奶与第二生牛奶混合的步骤。

公开(公告)号：US07948783B2

公开(公告)日：2011-05-24

申请号：US12515898

申请日：2007-11-12

申请人： Tadahiko Sugibayashi ,  Takeshi Honda ,  Noboru Sakimura ,  Nobuyuki Ishiwata ,  Shuichi Tahara

发明人： Tadahiko Sugibayashi ,  Takeshi Honda ,  Noboru Sakimura ,  Nobuyuki Ishiwata ,  Shuichi Tahara

IPC分类号： G11C15/02

CPC分类号： H01L27/228 ,  B82Y10/00 ,  B82Y25/00 ,  G11C11/161 ,  G11C11/1655 ,  G11C11/1659 ,  G11C11/1673 ,  G11C11/1675 ,  H01F10/3254 ,  H01F10/3272 ,  H01L43/08

摘要： An MRAM comprises: a plurality of magnetic memory cells each having a magnetoresistive element; and a magnetic field application section. The magnetic field application section applies an offset adjustment magnetic field in a certain direction to the plurality of magnetic memory cells from outside the plurality of magnetic memory cells. Respective data stored in the plurality of magnetic memory cells become the same when the offset adjustment magnetic field is removed.

摘要翻译： MRAM包括：多个具有磁阻元件的磁存储单元; 和磁场施加部。 磁场施加部从多个磁存储单元的外部向多个磁存储单元施加一定方向的偏移调整磁场。 当去除偏移调整磁场时，存储在多个磁存储单元中的各个数据变得相同。

公开(公告)号：US07887705B2

公开(公告)日：2011-02-15

申请号：US12066729

申请日：2005-11-08

申请人： Takeshi Honda ,  Julia Takako Honda

发明人： Takeshi Honda ,  Julia Takako Honda

IPC分类号： C02F3/28 ,  C02F11/04

CPC分类号： C02F3/28 ,  C02F11/04 ,  C02F2103/005 ,  C02F2103/20 ,  C02F2303/02 ,  Y02E50/343 ,  Y02W10/23

摘要： Improvements on a system for treating residual water, presents a new solution for the conformation of a system for treating residual water and for such purpose, it basically consists of a lower blanket (1), preferably produced in PVC, and of a cover blanket (2), which is also preferably produced in PVC, in any color, which may be double-faced, including, in the present model still features a reactor (3), a deep chamber (4) and an anaerobic pond (5), and such elements may be excavated in the soil (S) or made of stonemasonry or any kind of suitable material for this purpose.

摘要翻译： 用于处理残留水的系统的改进为处理残余水的系统的构象提供了新的解决方案，并且为此目的，其基本上由优选以PVC制成的下毯（1）和覆盖层（ 2），其也优选以PVC制成，可以是双面的，包括在本模型中还包括反应器（3），深室（4）和厌氧池（5）， 并且这些元素可以在土壤（S）中挖掘，或者由石砌体或其它任何适合的材料制成。

公开(公告)号：US07813164B2

公开(公告)日：2010-10-12

申请号：US11661205

申请日：2005-08-26

申请人： Tadahiko Sugibayashi ,  Takeshi Honda ,  Noboru Sakimura

发明人： Tadahiko Sugibayashi ,  Takeshi Honda ,  Noboru Sakimura

IPC分类号： G11C11/00

CPC分类号： G11C11/15 ,  H01L27/228 ,  H01L43/08

摘要： A magneto-resistance element includes a free layer, a fixed layer and a non-magnetic layer interposed between the free layer and the fixed layer. The free layer has a first magnetic layer, a second magnetic layer, a third magnetic layer, a first non-magnetic layer interposed between the first magnetic layer and the second magnetic layer, and a second non-magnetic layer interposed between the second magnetic layer and the third magnetic layer. The first magnetic layer, the second magnetic layer and the third magnetic layer are coupled such that spontaneous magnetizations have a helical structure.

摘要翻译： 磁阻元件包括位于自由层和固定层之间的自由层，固定层和非磁性层。 自由层具有第一磁性层，第二磁性层，第三磁性层，介于第一磁性层和第二磁性层之间的第一非磁性层，以及介于第二磁性层之间的第二非磁性层 和第三磁性层。 第一磁性层，第二磁性层和第三磁性层被耦合，使得自发磁化具有螺旋结构。