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公开(公告)号：US11497818B2
公开(公告)日：2022-11-15
申请号：US15987500
申请日：2018-05-23
发明人： François Lux , Olivier Tillement , Maxime Saint Jean , Pierre Mowat , Pascal Perriat , Stéphane Roux , Anna Mignot
摘要： The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy.
The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.
Thus, the nanoparticles according to the invention, with diameter d1 between 1 and 20 nm, each comprise a polyorganosiloxane (POS) matrix including gadolinium cations optionally associated with doping cations; a chelating graft C1 DTPABA (diethylenetriaminepentaacetic acid bisanhydride) bound to the POS matrix by an —Si—C— covalent bond, and present in sufficient quantity to be able to complex all the gadolinium cations; and optionally another functionalizing graft Gf* bound to the POS matrix by an —Si—C— covalent bond (where Gf* can be derived from a hydrophilic compound (PEG); from a compound having an active ingredient PA1; from a targeting compound; from a luminescent compound (fluorescein).
The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.-
公开(公告)号：US10920534B2
公开(公告)日：2021-02-16
申请号：US16408824
申请日：2019-05-10
发明人： Christian Hurtevent , Salima Baraka-Lokmane , John-Richard Ordonez-Varela , Olivier Tillement , Thomas Brichart , Mattéo Martini
摘要： A method for adjusting, to a pre-determined value, the level of a mineral deposition or corrosion inhibitor injected into a gas or oil well. Using of the time-resolved fluorescence method for detecting and quantifying a mineral deposition or corrosion inhibitor in a fluid from an oil or gas production well.
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公开(公告)号：US20170002629A1
公开(公告)日：2017-01-05
申请号：US15105328
申请日：2014-12-19
发明人： Christian HURTEVENT , Salima BARAKA-LOKMANE , John-Richard ORDONEZ-VARELA , Olivier TILLEMENT , Thomas BRICHART , Matteo MARTINI
CPC分类号： E21B37/06 , C09K8/528 , C09K8/54 , C09K2208/32 , E21B41/02 , E21B47/00 , E21B47/102
摘要： A method for adjusting, to a pre-determined value, the level of a mineral deposition or corrosion inhibitor injected into a gas or oil well. Using of the time-resolved fluorescence method for detecting and quantifying a mineral deposition or corrosion inhibitor in a fluid from an oil or gas production well.
摘要翻译： 调节注入气体或油井的矿物沉积或腐蚀抑制剂的水平的预定值的方法。 使用时间分辨荧光法检测和定量来自油气生产井的流体中的矿物沉积或腐蚀抑制剂。
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公开(公告)号：US20190264541A1
公开(公告)日：2019-08-29
申请号：US16408824
申请日：2019-05-10
发明人： Christian HURTEVENT , Salima BARAKA-LOKMANE , John-Richard ORDONEZ-VARELA , Olivier TILLEMENT , Thomas BRICHART , Mattéo MARTINI
摘要： A method for adjusting, to a pre-determined value, the level of a mineral deposition or corrosion inhibitor injected into a gas or oil well. Using of the time-resolved fluorescence method for detecting and quantifying a mineral deposition or corrosion inhibitor in a fluid from an oil or gas production well.
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公开(公告)号：US10987435B2
公开(公告)日：2021-04-27
申请号：US15677167
申请日：2017-08-15
发明人： François Lux , Olivier Tillement , Maxime Saint Jean , Pierre Mowat , Pascal Perriat , Stéphane Roux , Anna Mignot
摘要： The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy.
The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.-
公开(公告)号：US10106722B2
公开(公告)日：2018-10-23
申请号：US15106610
申请日：2014-12-19
发明人： Christian Hurtevent , Salima Baraka-Lokmane , John-Richard Ordonez-Varela , Olivier Tillement , Fabien Rossetti , Mahmoud Ould Metidji
摘要： A copolymer containing a unit including an optionally neutralized styrene sulphonic acid unit and a unit containing at least one optionally neutralized (poly)carboxylic acid unit or a (poly)amido-amine unit, to inhibit or slow the formation of sulphide deposits during the extraction of gas or oil. It also relates to a method to inhibit or slow the formation of sulphide deposits during the extraction of gas or oil, including the injection of a fluid containing the abovementioned copolymer into a wellbore, a subterranean formation or a gas or oil well.
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公开(公告)号：US20180264145A1
公开(公告)日：2018-09-20
申请号：US15987500
申请日：2018-05-23
发明人： François LUX , Olivier TILLEMENT , Maxime SAINT JEAN , Pierre MOWAT , Pascal PERRIAT , Stéphane ROUX , Anna MIGNOT
摘要： The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy.The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.Thus, the nanoparticles according to the invention, with diameter d1 between 1 and 20 nm, each comprise a polyorganosiloxane (POS) matrix including gadolinium cations optionally associated with doping cations; a chelating graft C1 DTPABA (diethylenetriaminepentaacetic acid bisanhydride) bound to the POS matrix by an —Si—C— covalent bond, and present in sufficient quantity to be able to complex all the gadolinium cations; and optionally another functionalizing graft Gf* bound to the POS matrix by an —Si—C— covalent bond (where Gf* can be derived from a hydrophilic compound (PEG); from a compound having an active ingredient PA1; from a targeting compound; from a luminescent compound (fluorescein).The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.
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公开(公告)号：US20180008729A1
公开(公告)日：2018-01-11
申请号：US15677167
申请日：2017-08-15
发明人： François LUX , Olivier TILLEMENT , Maxime SAINT JEAN , Pierre MOWAT , Pascal PERRIAT , Stéphane ROUX , Anna MIGNOT
摘要： The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy.The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.
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公开(公告)号：US10329879B2
公开(公告)日：2019-06-25
申请号：US15105328
申请日：2014-12-19
发明人： Christian Hurtevent , Salima Baraka-Lokmane , John-Richard Ordonez-Varela , Olivier Tillement , Thomas Brichart , Matteo Martini
摘要： A method for adjusting, to a pre-determined value, the level of a mineral deposition or corrosion inhibitor injected into a gas or oil well. Using of the time-resolved fluorescence method for detecting and quantifying a mineral deposition or corrosion inhibitor in a fluid from an oil or gas production well.
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10.发明申请USE OF A COPOLYMER MADE FROM STYRENE SULPHONIC ACID TO INHIBIT OR SLOW THE FORMATION OF SULPHIDE DEPOSITS 审中-公开使用苯乙烯磺酸的共聚物抑制或缓慢形成硫化物沉积物公开(公告)号：US20160333251A1
公开(公告)日：2016-11-17
申请号：US15106610
申请日：2014-12-19
发明人： Christian HURTEVENT , Salima BARAKA-LOKMANE , John-Richard ORDONEZ-VARELA , Olivier TILLEMENT , Fabien ROSSETTI , Mahmoud OULD METIDJI
CPC分类号： C09K8/532 , C08F12/30 , E21B37/06 , C08F212/14 , C08F222/02
摘要： A copolymer containing a unit including an optionally neutralised styrene sulphonic acid unit and a unit containing at least one optionally neutralised (poly)carboxylic acid unit or a (poly)amido-amine unit, to inhibit or slow the formation of sulphide deposits during the extraction of gas or oil. It also relates to a method to inhibit or slow the formation of sulphide deposits during the extraction of gas or oil, including the injection of a fluid containing the abovementioned copolymer into a wellbore, a subterranean formation or a gas or oil well.
摘要翻译： 含有包含任选中和的苯乙烯磺酸单元和含有至少一个任选中和的（多）羧酸单元或（聚）酰胺 - 胺单元的单元的单元的共聚物，以在提取期间抑制或减缓硫化物沉积物的形成 的气体或油。 它还涉及在气体或油的提取期间抑制或减缓硫化物沉积物的形成的方法，包括将含有上述共聚物的流体注入井眼，地下地层或气体或油井中。
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