公开(公告)号：US20240350975A1

公开(公告)日：2024-10-24

申请号：US18686831

申请日：2022-08-25

申请人： Orgenesis Inc. ,  UNIVERSITY OF CALIFORNIA DAVIS

发明人： REEM J. MIARI ,  VERED CAPLAN ,  GERHARD BAUER ,  BRIAN FURY

IPC分类号： B01D61/14 ,  B01D63/16

CPC分类号： B01D61/145 ,  B01D63/16 ,  B01D2311/14 ,  B01D2321/2058 ,  B01D2325/02834

摘要： There is provided a method of concentrating functional biological components within a liquid suspension, the method comprising: providing a system comprising an ultrafiltration/concentration unit (UCU), the UCU comprising a first chamber for receiving therein the liquid suspension. a second chamber for receiving therein the filtrate, and a filter disposed in a fluid path therebetween. the filter comprising pores sizes so as to prevent passage therethrough of the biological components: introducing the liquid suspension into the first chamber: maintaining a pressure in the first chamber being no greater than approximately 2 bar; maintaining a pressure in the second chamber being lower than that of the first chamber: and harvesting the concentrated biological components: wherein a retentate is obtained in which the concentration of the biological components therewithin is increased. relative to the liquid suspension. by a factor of at least fifty. and wherein a majority of the biological components in the retentate are functional.

公开(公告)号：US20200046320A1

公开(公告)日：2020-02-13

申请号：US15999109

申请日：2017-02-18

申请人： UNIVERSITY OF SOUTHERN CALIFORNIA ,  REGENTS OF THE UNIVERSITY OF CALIFORNIA, DAVIS

发明人： Robert G. WODNICKI ,  Qifa ZHOU ,  Thomas Matthew CUMMINS ,  Douglas N. STEPHENS ,  Katherine W. FERRARA

IPC分类号： A61B8/00 ,  H01L41/04 ,  B06B1/06 ,  H01L41/113

摘要： A modular array includes modular array includes one or more array modules. Each array module includes one or more transducer arrays, where each of the one or more transducer arrays includes a plurality of piezoelectric elements; a conducting interposer arranged and configured to provide acoustic absorbing backing for the one or more transducer arrays; and one or more Application Specific Integrated Circuits (ASICs). The conducting interposer and the one or more ASICs are in electrical contact with each other at a first direct electrical interface. Additionally, the conducting interposer and the one or more transducer arrays are in electrical contact with each other at a second direct electrical interface.

公开(公告)号：US20030077676A1

公开(公告)日：2003-04-24

申请号：US10112788

申请日：2002-03-28

申请人： University of California, Davis Technology Transfer Center

发明人： Sally Joan Denardo ,  Michelle Denise Winthrop ,  Gerald Louis Denardo

IPC分类号： G01N033/574 ,  C07K016/30

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K14/4748 ,  C07K16/30 ,  C07K2317/622 ,  G01N33/57415 ,  G01N33/57449 ,  G01N33/57492

摘要： This invention provides novel antibodies that specifically bind to the cancer antigen MUC-1. The antibodies are useful targeting moieties for specifically directing imaging agents and various thereapeutic moieties to a cancer.

摘要翻译： 本发明提供了特异性结合癌抗原MUC-1的新型抗体。 抗体是有用的靶向部分，用于将成像剂和各种治疗部分特异性地引导至癌症。

公开(公告)号：US20240197795A1

公开(公告)日：2024-06-20

申请号：US18006940

申请日：2021-07-27

申请人： Boadie DUNLOP ,  Oliver FIEHN ,  Christopher Robert BRYDGES ,  DUKE UNIVERSITY ,  EMOORY UNIVERSITY ,  UNIVERSITY OF CALIFORNIA, DAVIS

发明人： Rima F. Kaddurah-Daouk ,  Augustus John Rush, JR. ,  Boadie W. Dunlop ,  Oliver Fiehn ,  Christopher R. Brydges ,  W. Edward Craighead ,  Helen Mayberg

IPC分类号： A61K35/742 ,  A61K45/06 ,  G01N33/53

CPC分类号： A61K35/742 ,  A61K45/06 ,  G01N33/5308 ,  G01N2800/304 ,  G01N2800/52

摘要： Described herein are methods of identifying, characterizing, and treating depression and anxiety in a subject by modulating indoles associated with tryptophan metabolism in the subject and subject's gut microbiome.