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公开(公告)号：US20250145975A1
公开(公告)日：2025-05-08
申请号：US18941989
申请日：2024-11-08
Applicant: University of Kentucky Research Foundation
Inventor： Xiaoyue Yang , Sheng Tong
Abstract: Methods which make use of baculovirus vector (BV)-magnetic nanoparticle (BV-MNP) complexes to facilitate in vivo delivery of clustered regularly interspaced palindromic repeat (CRISPR) systems are provided. BV-MNP complexes carrying a CRISPR nuclease and a guide RNA having homology to an immune checkpoint gene can be administered to a subject to inhibit the immune checkpoint gene. Inhibition of the immune checkpoint gene can promote a desired immune response in the subject. Methods which leverage the contrast provided by MNPs in BV-MNP complexes in combination with magnetic resonance imaging (MRI) to detect in vivo delivery of CRISPR systems are also provided.
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公开(公告)号：US12274701B2
公开(公告)日：2025-04-15
申请号：US18183110
申请日：2023-03-13
Applicant: University of Kentucky Research Foundation
Inventor： Jayakrishna Ambati , Benjamin Fowler
IPC: A61K31/506 , A61K31/513 , A61K31/52 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , C07D405/04 , C07D411/04 , A61P25/16 , A61P25/28
Abstract: The present disclosure relates to compositions and methods for treating retinal damage and/or retinal degradation. More specifically, this disclosure relates to methods for treating degradation of the retinal pigment epithelium by administering compositions comprising a nucleoside and/or a nucleoside or nucleotide reverse transcriptase inhibitor.
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公开(公告)号：US12236581B2
公开(公告)日：2025-02-25
申请号：US16953027
申请日：2020-11-19
Applicant: University of Kentucky Research Foundation
Inventor： David J Minion
Abstract: A method of anatomic classification of blood vessel anatomy in aneurysms includes the steps of accessing an image of a blood vessel, analyzing the image to identify a point of divergence of the blood vessel and one or more additional points of reference of the blood vessel. One or more distances are then measured between the point of divergence of the blood vessel and at least one of the one or more additional points of reference. The aneurysm is then classified based upon the measured distances. A method of treatment of an aneurysm in a blood vessel further includes implanting one or more devices within the blood vessel for treatment of the aneurysm.
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公开(公告)号：US12215125B2
公开(公告)日：2025-02-04
申请号：US18244136
申请日：2023-09-08
Applicant: University of Kentucky Research Foundation
Inventor： Heather R. Campbell
IPC: C07H3/02
Abstract: A D-tagatose spray-drying feed formulation is a mixture of D-tagatose and a functional excipient co-dissolved in a solvent to produce a excipient/D-tagatose composite having a glass transition temperature of greater than 30° C. A method of spray-drying D-tagatose includes the steps of (a) preparing the D-tagatose spray-drying formulation, (b) atomizing the D-tagatose spray-drying formulation in a drying chamber containing a hot inert processing gas and evaporating droplets to produce solid particles of excipient/D-tagatose composite and (c) separating and collecting the solid particles of excipient/D-tagatose composite from the processing gas.
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5.发明授权公开(公告)号：US12208083B2
公开(公告)日：2025-01-28
申请号：US17880101
申请日：2022-08-03
Applicant: University of Kentucky Research Foundation
Inventor： Craig R. Rush
IPC: A61K31/357 , A61K31/137 , A61P25/30
Abstract: Combinations and methods for treating a subject experiencing or at risk of experiencing an undesired consequence of stimulant use are provided. The combinations include topiramate and phentermine. The methods include administering an effective dose of a combination of topiramate and phentermine to a subject. In some embodiments, the methods include administering an effective dose of a combination of topiramate and phentermine to a subject with cocaine use disorder.
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Patent Agency Ranking
公开(公告)号：US20240424282A1
公开(公告)日：2024-12-26
申请号：US18744158
申请日：2024-06-14
Applicant: University of Kentucky Research Foundation
Inventor： Dongfang Wang , Joseph B. Zwischenberger , Cherry Ballard-Croft , Li Li , Jinsong Chen
IPC: A61M60/178 , A61M60/117 , A61M60/268 , A61M60/435 , A61M60/538 , A61M60/554 , A61M60/861 , A61M60/896
Abstract: A ventricular assist device includes a cannula including a lumen. An inlet valve on the cannula is in communication with the lumen. An outlet valve on the cannula is in communication with the lumen. A pump is connected to the lumen and adapted to draw blood through the inlet valve from the ventricle into the lumen and deliver blood from the lumen through the outlet valve into an aorta or pulmonary artery of the a patient into which the device is implanted. The ventricular assist device also includes an anchor including (a) a graft adapted to receive and hold the cannula and (b) an anchor retainer carried on a first end of the graft and adapted to secure the anchor to the ventricle wall.
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公开(公告)号：US20240419162A1
公开(公告)日：2024-12-19
申请号：US18748909
申请日：2024-06-20
Applicant: University of Kentucky Research Foundation
Inventor： Peng Wang , Matthew Russell
IPC: G05B23/02
Abstract: The present disclosure describes methods for machine condition monitoring from unlabeled sensing data. The methods include providing a plurality of sensors including at least one acceleration sensor. The plurality of sensors are adapted for obtaining a plurality of high-frequency time series inputs from an operating rotating machine or machine component. The plurality of high-frequency time series inputs received from the plurality of sensors are subjected to one or more augmentation transformations that diversify the plurality of high-frequency time series inputs without impacting condition information. This provides a plurality of augmented inputs which, by the one or more augmentation transformations, are selected to randomize input amplitude and phase.
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公开(公告)号：US20240376622A1
公开(公告)日：2024-11-14
申请号：US18659851
申请日：2024-05-09
Applicant: University of Kentucky Research Foundation
Inventor： Xin Gao , Min Xiao , Kunlei Liu , Aron Patrick
Abstract: A method of recycling solar panels, including a frame, glass, silicon wafers, and wiring, incorporates the steps of: (a) delaminating the solar panel by breaking down ethylene-vinyl acetate polymer in the solar panel to generate fumed acetic acid, (b) dissolving silver from the silicon wafers of the solar panel in a metal recovery solution using the fumed acetic acid generated during the delaminating and (c) recovering the dissolved silver from the metal recovery solution.
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公开(公告)号：US20240375042A1
公开(公告)日：2024-11-14
申请号：US18660700
申请日：2024-05-10
Applicant: University of Kentucky Research Foundation
Inventor： Jesse Thompson , Min Xiao , Kunlei Liu
Abstract: A packing for gas separation from a liquid absorbent includes a body having a corrugated surface or surface sub-texture adapted to create local turbulence within a liquid absorbent with which the body has been wetted. The body may also has a corrugated profile wherein the surface sub-texture comprises a plurality of individual scallops and the corrugated profile comprises a plurality of individual furrow with between about 2 and about 50 individual scallops per furrow. The packing is useful in a method for gas separation from a liquid absorbent.
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公开(公告)号：US12139718B2
公开(公告)日：2024-11-12
申请号：US16625262
申请日：2018-06-21
Applicant: University of Kentucky Research Foundation
Inventor： Matthew Edward Humphry , Shengming Yang , Qiulin Qin
Abstract: The present invention provides a method for modulating the alkaloid content of a plant (e.g. a tobacco plant), the method comprising modifying said plant by modulating the activity or expression of at least one Nic1 ERF gene. The present invention also provides for the use of at least one Nic1 ERF gene for modulating the alkaloid content of a plant, as well as tobacco cells, plants, plant propagation materials, harvested leaves, processed tobaccos, or tobacco products obtainable in accordance with the invention.
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