公开(公告)号：US6057426A

公开(公告)日：2000-05-02

申请号：US71353

申请日：1998-04-30

申请人： Werner Lesslauer ,  Ulrike Utans-Schneitz

发明人： Werner Lesslauer ,  Ulrike Utans-Schneitz

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K38/19 ,  A61P29/00 ,  C07K14/52 ,  C07K16/24 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/08 ,  C12N5/10 ,  C12N15/09 ,  C12N15/19 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/53

CPC分类号： C07K14/523 ,  A61K38/00 ,  C07K2319/02 ,  Y10S530/81 ,  Y10S530/812

摘要： The present invention relates to the discovery of novel genes and proteins, which function in pathways involved in brain pathogenesis. In particular, the novel genes and proteins relate to inflammatory tissue responses caused by brain injuries such trauma, ischemia or autoimmune-inflammation or other diseases or processes related to neuroinflammation. The compounds disclosed in the present invention are useful as therapeutics, diagnostics and in screening assays.

公开(公告)号：US06537794B1

公开(公告)日：2003-03-25

申请号：US09426326

申请日：1999-10-25

申请人： Werner Lesslauer ,  Ulrike Utans-Schneitz

发明人： Werner Lesslauer ,  Ulrike Utans-Schneitz

IPC分类号： C12N1500

CPC分类号： C07K14/523 ,  A61K38/00 ,  C07K2319/02 ,  Y10S530/81 ,  Y10S530/812

摘要： The present invention relates to the discovery of novel genes and proteins, which function in pathways involved in brain pathogenesis. In particular, the novel genes and proteins relate to inflammatory tissue responses caused by brain injuries such trauma, ischemia or autoimmune-inflammation or other diseases or processes related to neuroinflammation. The compounds disclosed in the present invention are useful as therapeutics, diagnostics and in screening assays.

摘要翻译： 本发明涉及在脑发病机制中起作用的新基因和蛋白质的发现。 特别地，新颖的基因和蛋白质涉及由脑损伤引起的炎性组织反应，如创伤，缺血或自身免疫性炎症或其他与神经炎症相关的疾病或过程。 本发明公开的化合物可用作治疗，诊断和筛选测定。