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8 条记录 (耗时 0.018 秒)

    Human TNF receptor
    3.
    发明授权
    Human TNF receptor 失效
    人类TNF受体

    公开(公告)号：US08163522B1

    公开(公告)日：2012-04-24

    申请号：US08444791

    申请日：1995-05-19

    申请人： Manfred Brockhaus ,  Reiner Gentz ,  Dembic Zlatko ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

    发明人： Manfred Brockhaus ,  Reiner Gentz ,  Dembic Zlatko ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

    IPC分类号： C12N15/12 ,  C12N15/63 ,  C12N5/10 ,  C12P21/00

    CPC分类号： C07K14/7151 ,  C07K16/2866 ,  C12N2799/026 ,  Y10S930/144

    摘要： The present invention is concerned with non-soluble proteins and soluble or insoluble fragments thereof, which bind TNF, in homogeneous form, as well as their physiologically compatible salts, especially those proteins having a molecular weight of about 55 or 75 kD (non-reducing SDS-PAGE conditions), a process for the isolation of such proteins, antibodies against such proteins, DNA sequences which code for non-soluble proteins and soluble or non-soluble fragments thereof, which bind TNF, as well as those which code for proteins comprising partly of a soluble fragment, which binds TNF, and partly of all domains except the first of the constant region of the heavy chain of human immunoglobulins and the recombinant proteins coded thereby as well as a process for their manufacture using transformed pro- and eukaryotic host cells.

    摘要翻译： 本发明涉及不溶性蛋白质及其可溶性或不溶性片段，其以均质形式结合TNF，以及它们的生理相容性盐，特别是分子量为约55或75kD的蛋白质（非还原型 SDS-PAGE条件），分离这些蛋白质的方法，针对这些蛋白质的抗体，编码结合TNF的不溶性蛋白质的DNA序列和可溶性或非可溶性片段，以及编码蛋白质的蛋白质 其部分包含结合TNF的可溶性片段，以及部分除了人免疫球蛋白重链的恒定区域的第一个区域以外的所有结构域，以及由此编码的重组蛋白质以及其使用转化的真核和真核生物的方法 宿主细胞。

    Human TNF receptor fusion protein
    4.
    发明授权
    Human TNF receptor fusion protein 失效
    人TNF受体融合蛋白

    公开(公告)号：US08063182B1

    公开(公告)日：2011-11-22

    申请号：US08444790

    申请日：1995-05-19

    申请人： Manfred Brockhaus ,  Reiner Gentz ,  Dembic Zlatko ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

    发明人： Manfred Brockhaus ,  Reiner Gentz ,  Dembic Zlatko ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

    IPC分类号： C07K14/715 ,  A61P29/00 ,  A61K38/17 ,  C07K19/00 ,  C07H21/04

    CPC分类号： C07K14/7151 ,  C07K16/2866 ,  C12N2799/026 ,  Y10S930/144

    摘要： The present invention is concerned with non-soluble proteins and soluble or insoluble fragments thereof, which bind TNF, in homogeneous form, as well as their physiologically compatible salts, especially those proteins having a molecular weight of about 55 or 75 kD (non-reducing SDS-PAGE conditions), a process for the isolation of such proteins, antibodies against such proteins, DNA sequences which code for non-soluble proteins and soluble or non-soluble fragments thereof, which bind TNF, as well as those which code for proteins comprising partly of a soluble fragment, which binds TNF, and partly of all domains except the first of the constant region of the heavy chain of human immunoglobulins and the recombinant proteins coded thereby as well as a process for their manufacture using transformed pro- and eukaryotic host cells.

    摘要翻译： 本发明涉及不溶性蛋白质及其可溶性或不溶性片段，其以均质形式结合TNF，以及它们的生理相容性盐，特别是分子量为约55或75kD的蛋白质（非还原型 SDS-PAGE条件），分离这些蛋白质的方法，针对这些蛋白质的抗体，编码结合TNF的不溶性蛋白质的DNA序列和可溶性或非可溶性片段，以及编码蛋白质的蛋白质 其部分包含结合TNF的可溶性片段，以及部分除了人免疫球蛋白重链的恒定区域的第一个区域以外的所有结构域，以及由此编码的重组蛋白质以及其使用转化的真核和真核生物的方法 宿主细胞。

    Chemokine
    5.
    发明授权
    Chemokine 有权
    趋化因子

    公开(公告)号：US06537794B1

    公开(公告)日：2003-03-25

    申请号：US09426326

    申请日：1999-10-25

    申请人： Werner Lesslauer ,  Ulrike Utans-Schneitz

    发明人： Werner Lesslauer ,  Ulrike Utans-Schneitz

    IPC分类号： C12N1500

    CPC分类号： C07K14/523 ,  A61K38/00 ,  C07K2319/02 ,  Y10S530/81 ,  Y10S530/812

    摘要： The present invention relates to the discovery of novel genes and proteins, which function in pathways involved in brain pathogenesis. In particular, the novel genes and proteins relate to inflammatory tissue responses caused by brain injuries such trauma, ischemia or autoimmune-inflammation or other diseases or processes related to neuroinflammation. The compounds disclosed in the present invention are useful as therapeutics, diagnostics and in screening assays.

    摘要翻译： 本发明涉及在脑发病机制中起作用的新基因和蛋白质的发现。 特别地，新颖的基因和蛋白质涉及由脑损伤引起的炎性组织反应，如创伤，缺血或自身免疫性炎症或其他与神经炎症相关的疾病或过程。 本发明公开的化合物可用作治疗，诊断和筛选测定。