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公开(公告)号：US20160159847A1
公开(公告)日：2016-06-09
申请号：US15019795
申请日：2016-02-09
发明人： Zer-Ran YU , Be-Jen WANG , Shu-Mei LIN , Hua-Ching LIN , Ming-Hsi CHUANG , Chu-Ting LIU , Chiu-Ying PENG , Lin-Hsiang CHUANG
CPC分类号： C07J1/007 , A61K35/50 , C07J1/0055 , Y02P20/544
摘要： The present invention provides a method of separating estrogen from placenta, which uses supercritical fluid technique to load the placenta powder of human body or sheep, pig, deer and other animals into an extraction tank. Under the operating conditions of preset pressure and temperature, supercritical solvent is added into the extraction tank to extract estrogen from placenta, so as to acquire de-estrogen placenta powder and placenta extract liquor. Under the same condition, the de-estrogen placenta extract liquor and supercritical solvent are added by a preset volume flow ratio into an adsorption tank. The estrogen in the placenta extract liquor is adsorbed by the adsorption tank to obtain de-estrogen placenta extract. It is then eluted with ethanol solution by gradient proportion to obtain purified natural estrogen.
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2.发明申请METHOD OF USING SUPERCRITICAL FLUID TECHNOLOGY TO SEPARATE AND PURIFY FUNCTIONAL COMPONENTS OF ANTRODIA CAMPHORATA 有权超临界流体技术分离和纯化ANTRODIA CAMPHORATA功能成分的方法公开(公告)号：US20160257768A1
公开(公告)日：2016-09-08
申请号：US14828658
申请日：2015-08-18
发明人： Ming-Hsi Chuang , Chu-Ting Lin , I-Lung Yu , Lin-Hsiang Chuang
CPC分类号： C08B37/0003 , C07J9/005 , C07J63/008 , Y02P20/544
摘要： A method of using supercritical fluid technology to separate and purify the functional components of Antrodia cinnamomea is described. Triterpenoids and polysaccharides of Antrodia cinnamomea are extracted from a fractionation tank containing extract of Antrodia cinnamomea and supercritical solvent at a set temperature and pressure. The extracted functional components and supercritical solvent are then continuously fed into three separating tanks at a set temperature and a pressure below that of the aforesaid pressure to obtain various functional components of triterpenoids and polysaccharides from the Antrodia cinnamomea feed in each separating tank.
摘要翻译： 描述了使用超临界流体技术分离和纯化樟芝的功能组分的方法。 在设定的温度和压力下，从含有抗氧化樟脑提取物和超临界溶剂的分馏罐中提取三萜类和多糖。 然后将提取的功能组分和超临界溶剂在设定温度和低于上述压力的压力下连续进料到三个分离罐中，以从每个分离罐中得到来自防腐剂（Cinrotoia cinnamomea）进料的三萜类化合物和多糖的各种功能组分。
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公开(公告)号：US20160051591A1
公开(公告)日：2016-02-25
申请号：US14702077
申请日：2015-05-01
发明人： Zer-Ran YU , Be-Jen WANG , Tsao-Chen WEI , Hua-Ching LIN , Ming-Hsi CHUANG , Chu-Ting LIU , I-Lung YU , Chiu-Ying PENG , Lin-Hsiang CHUANG
IPC分类号： A61K35/50 , B01D11/02 , A61K31/565
CPC分类号： A61K35/50 , A61K31/565 , B01D11/0203
摘要： The present invention provides a method for the separation of placenta functional ingredients. By using the supercritical fluid technology, the placenta powder is placed inside an extraction tank, under the predetermined pressure and temperature; the supercritical CO2 solvent is flown into the adsorption tank, in order to deodorize the fishy smell of the placenta powder, and extract the oil of the placenta powder. Under the same operating conditions as mentioned above, the deodorized and extracted placenta powder and supercritical CO2/ethanol solvents are flown into an adsorption tank at the predetermined volumetric flow rate ratio to adsorb the estrogen of placenta powder to get the estrogen-removed placenta peptide extracts. Afterwards, supercritical CO2/ethanol solvents are separated by rapid decompression to get the functional ingredients of placenta powder.
摘要翻译： 本发明提供了分离胎盘功能成分的方法。 通过使用超临界流体技术，将胎盘粉置于提取罐内，在预定的压力和温度下; 将超临界CO2溶剂流入吸附罐，以除臭胎盘粉末的鱼腥味，并提取胎盘粉末的油。 在与上述相同的操作条件下，除臭和提取的胎盘粉末和超临界CO2 /乙醇溶剂以预定的体积流速比流入吸附罐，以吸附胎盘粉末的雌激素，得到雌激素去除的胎盘肽提取物 。 然后，通过快速减压分离超临界CO2 /乙醇溶剂，得到胎盘粉末的功能成分。
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公开(公告)号：US10214719B2
公开(公告)日：2019-02-26
申请号：US15675985
申请日：2017-08-14
发明人： Ming-Hsi Chuang , Chu-Ting Liu , I-Lung Yu , Lin-Hsiang Chuang
摘要： A method of culturing Antrodia cinnamomea with high Triterpenoids includes mixing a malt extract, glucose, peptone, agar, and a mushroom's extract with distilled water to obtain a culture medium; providing the culture medium to a high-pressure sterilization machine for sterilization to obtain a sterilized culture medium; providing the sterilized culture medium to an incubator in a disinfection environment to obtain a solidified culture medium after a predetermined time; transplanting Antrodia cinnamomeas strains to the solidified culture medium at separated positions; and exposing the solidified culture medium under a beam.
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公开(公告)号：US20170226042A1
公开(公告)日：2017-08-10
申请号：US15134477
申请日：2016-04-21
发明人： Ming-Hsi Chuang , Chiu-Ying Peng , Cheng-Yu Chi , Hsin-Yu Chung , Chu-Ting Liu , Hui-Chen Kuo
CPC分类号： C07C51/47 , C07C51/42 , C07C59/52 , G01N33/5011 , Y02P20/544
摘要： A method of making artepillin C in propolis includes the following steps: A. Mix propolis with ethanol to obtain a propolis-ethanol extract; B. Provide supercritical carbon dioxide and the propolis-ethanol extract to a chromatographic column to separate wax and artepillin C, and then remove the wax at a bottom of the chromatographic column and collect the artepillin C containing isolate at a top of the chromatographic column; and C. Test the artepillin C by a cytotoxicity test, a cell morphology analysis, a cell cycle and apoptosis test, and a cell motility metastasis test to find an anti-cancer effect of the artepillin C containing isolate.
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公开(公告)号：US20170274026A1
公开(公告)日：2017-09-28
申请号：US15134482
申请日：2016-04-21
发明人： Ming-Hsi Chuang , Chiu-Ying Peng , Hsin-Yu Chung , Cheng-Yu Chi , Chu-Ting Liu , Hui-Chen Kuo
CPC分类号： A61K36/07 , A61K2236/37 , A61K2236/55 , G01N33/5011 , G01N33/5014 , G01N33/5026 , G01N33/5029
摘要： A method of making triterpenoids from petri dish cultured Antrodia cinnamomea includes: A. providing petri dish cultured Antrodia cinnamomea in an extracting container; B. providing a supercritical solvent to the extracting container to obtain an Antrodia cinnamomea extract; sending the Antrodia cinnamomea extract to a chromatographic column to separate impurities and triterpenoids from the Antrodia cinnamomea extract, and removing the impurities, and collecting the triterpenoids containing fraction; and C. testing the bioactivity of the triterpenoids containing fraction by cytotoxicity test, cell morphology analysis, cell cycle and apoptosis test, and cell motility test to find an anti-cancer effect of the triterpenoids.
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公开(公告)号：US20170159008A1
公开(公告)日：2017-06-08
申请号：US15070132
申请日：2016-03-15
发明人： Ming-Hsi Chuang , Chu-Ting Liu , I-Lung Yu , Lin-Hsiang Chuang
摘要： A method of culturing Antrodia cinnamomea with high Triterpenoids includes mixing a malt extract, glucose, peptone, agar, and a mushroom extract with distilled water to obtain a culture medium; providing the culture medium to a high-pressure sterilization machine for sterilization to obtain a sterilized culture medium; providing the sterilized culture medium to an incubator in a disinfection environment to obtain a solidified culture medium after a predetermined time; transplanting Antrodia cinnamomeas strains to the solidified culture medium at separated positions; and exposing the solidified culture medium under a beam.
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8.发明申请METHOD FOR SEPARATING AND PURIFING FUNCTIONAL INGREDIENTS FROM PLACENTA USING SUPERCRITICAL FLUID TECHNOLOGY 审中-公开使用超临界流体技术分离和纯化来自PLACENTA的功能成分的方法公开(公告)号：US20160074773A1
公开(公告)日：2016-03-17
申请号：US14702388
申请日：2015-05-01
发明人： Zer-Ran YU , Be-Jen WANG , Shu-Mei LIN , Hua-Ching LIN , Ming-Hsi CHUANG , Chu-Ting LIU , I-Lung YU , Chiu-Ying PENG , Lin-Hsiang CHUANG
CPC分类号： B01D11/0203 , A61K35/50
摘要： The present invention provides a method to separate and purify functional ingredients in placenta using supercritical fluid technology, where, placenta extract liquid and supercritical CO2 solvent are guided into a fractionation tank constantly in a preset velocity at a preset temperature and pressure to extract peptides, proteins and other functional ingredients. And then, the solution is conveyed through the three fractionation tanks at a preset temperature and depressurized gradually to separate, fractionate and purify the content of placenta peptide and protein, so as to obtain the high purity of peptides, proteins, active factors and other functional ingredients.
摘要翻译： 本发明提供了一种使用超临界流体技术分离和纯化胎盘中的功能成分的方法，其中将胎盘提取液和超临界CO 2溶剂以预设的速度在预设的温度和压力下恒定地引导到分馏罐中以提取肽，蛋白质 和其他功能成分。 然后，将溶液在预设温度下通过三个分级罐输送并逐渐减压，分离，分馏和纯化胎盘肽和蛋白质的含量，以获得高纯度的肽，蛋白质，活性因子和其他功能 配料。
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公开(公告)号：US20200063098A1
公开(公告)日：2020-02-27
申请号：US16184708
申请日：2018-11-08
发明人： Ming-Hsi CHUANG , Lin-Hsiang CHUANG , Po-Cheng LIN , Chia-Hsin LEE , Yi-Chun LIN , Chi-Hsuan CHUANG , Shinn-Zong LIN , Chia-Yu CHANG , Ching-I SHEN
IPC分类号： C12N5/0793 , A61K35/30 , A61K31/365
摘要： Uses of n-butylidenephthalide (BP) in dopaminergic progenitor cell transplantation are provided, wherein the uses include using BP to enhance the therapeutic effect of dopaminergic progenitor cell transplantation, and using a combination of BP and BP-treated dopaminergic progenitor cells in dopaminergic progenitor cell transplantation. The uses especially relate to using BP to enhance the therapeutic effect of dopaminergic progenitor cell transplantation on Parkinson's disease.
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公开(公告)号：US20170342369A1
公开(公告)日：2017-11-30
申请号：US15675985
申请日：2017-08-14
发明人： Ming-Hsi Chuang , Chu-Ting Liu , I-Lung Yu , Lin-Hsiang Chuang
摘要： A method of culturing Antrodia cinnamomea with high Triterpenoids includes mixing a malt extract, glucose, peptone, agar, and a mushroom's extract with distilled water to obtain a culture medium; providing the culture medium to a high-pressure sterilization machine for sterilization to obtain a sterilized culture medium; providing the sterilized culture medium to an incubator in a disinfection environment to obtain a solidified culture medium after a predetermined time; transplanting Antrodia cinnamomeas strains to the solidified culture medium at separated positions; and exposing the solidified culture medium under a beam.
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