公开(公告)号：US20140099285A1

公开(公告)日：2014-04-10

申请号：US13803963

申请日：2013-03-14

申请人： UNHWA CORPORATION

发明人： Sun Mi HONG ,  Eun Kyong LEE ,  Young Woo JIN

IPC分类号： A61K36/258 ,  C12N5/04

CPC分类号： A61K36/258 ,  A01H4/005 ,  A23L33/10 ,  A23L33/105 ,  A23V2002/00 ,  C12N5/04 ,  A23V2200/30 ,  A23V2250/2124

摘要： The present invention relates to a composition for preventing or treating acquired immunodeficiency syndrome (AIDS), comprising one or more of the following: a homogenous cell line, and a lysate, an extract and a culture thereof as an active ingredient. The homogenous cell line, the lysate, the extract and the culture thereof, which are derived from a natural product, minimize adverse side effects of prior therapeutic agents and safe for the human body. Further, they effectively increase the count of T cells such as CD4+ T cells and decrease the number of HIVs, thereby preventing opportunistic infection, dysneuria, and neoplaia caused by immune incompetence, and ultimately the risk of death. Therefore, they are useful in preventing and treating AIDS, and relieving symptoms of AIDS.

摘要翻译： 本发明涉及用于预防或治疗获得性免疫缺陷综合征（AIDS）的组合物，其包含以下一种或多种：均质细胞系，其裂解物，提取物和培养物作为活性成分。 衍生自天然产物的均质细胞系，裂解物，提取物和培养物使得现有治疗剂的不利副作用最小化并对人体安全。 此外，它们有效地增加了T细胞如CD4 + T细胞的数量，并减少了HIV的数量，从而防止了免疫功能不全引起的机会感染，排尿困难和赘生物，最终导致死亡风险。 因此，它们有助于预防和治疗艾滋病，缓解艾滋病的症状。

公开(公告)号：US08790927B2

公开(公告)日：2014-07-29

申请号：US13755517

申请日：2013-01-31

申请人： Unhwa Corporation

发明人： Joong Hyun Park ,  Min Jung Lim ,  Il Seok Oh ,  Dae Hee Lee ,  Jung Chang Lee ,  Eun Kyong Lee ,  Young Woo Jin

IPC分类号： C12N5/00 ,  C12N5/02

CPC分类号： A61K36/13

摘要： The present invention relates to a composition for preventing or treating cancer, which contains, as an active ingredient, a Taxus cambium- or procambium-derived cell line; a lysate thereof; an extract thereof; or a culture medium thereof. The cell line, the lysate, the extract, and the culture medium has minimized side effects compared to the conventional therapeutic drugs, is safe to the human body, is involved directly in the growth of cancer to induce cancer cell death, and shows anticancer activity of inhibiting angiogenesis occurring in carcinogenesis. Accordingly, the cell line, the lysate, the extract and the culture medium is useful for the prevention, treatment and alleviation of cancer.

摘要翻译： 本发明涉及一种用于预防或治疗癌症的组合物，其含有作为有效成分的红豆杉形成层或原生动物来源的细胞系; 其裂解物; 其提取物; 或其培养基。 细胞系，裂解物，提取物和培养基与常规治疗药物相比具有最小化的副作用，对人体是安全的，直接参与癌症的生长以诱导癌细胞死亡，并且显示抗癌活性 抑制致癌作用中发生的血管生成。 因此，细胞系，裂解物，提取物和培养基可用于预防，治疗和缓解癌症。

公开(公告)号：US20160010099A1

公开(公告)日：2016-01-14

申请号：US14771483

申请日：2014-02-28

申请人： Young Woo JIN ,  Eun Kyong LEE ,  UNHWA CORPORATION

发明人： Young Woo JIN ,  Eun Kyong LEE ,  Mi Ok JANG ,  Bora PARK ,  Soo Ran LEE ,  Bo Rim YANG ,  Il Suk KIM ,  Il Seok OH

IPC分类号： C12N15/82

CPC分类号： C12N15/8205 ,  C12N5/04 ,  C12N15/8257

摘要： Plant cells express a target protein, a production method thereof, and a method of producing a target protein using the same are disclosed. The plant cells have introduced therein a recombinant vector containing gene(s) encoding a target protein, and the plant cells include plant cambial meristematic cells (CMC) or callus. The cambial meristematic cells (CMCs) are a cell line containing innately undifferentiated cells isolated from a plant, wherein the cell line is a cell line isolated from the cambial tissue of the plant and has meristematic continuity without going through dedifferentiation into callus. A system of expressing a target protein using the recombinant plant cells according to the present invention can overcome the problems of conventional plant cell culture. In addition, it shows significantly high transformation efficiency, and thus can produce large amounts of target proteins, including biopharmaceutical proteins.

摘要翻译： 公开了植物细胞表达靶蛋白，其生产方法和使用其的生产靶蛋白的方法。 植物细胞在其中引入含有编码靶蛋白的基因的重组载体，植物细胞包括植物成分分生细胞（CMC）或愈伤组织。 成像分生细胞（CMC）是含有从植物分离的天然未分化细胞的细胞系，其中细胞系是从植物的成像组织分离的细胞系，并且具有分生组织连续性，而不经过去分化成愈伤组织。 使用根据本发明的重组植物细胞表达靶蛋白的系统可以克服常规植物细胞培养的问题。 此外，它显示出显着的转化效率，因此可产生大量靶蛋白，包括生物制药蛋白。

公开(公告)号：US09095532B2

公开(公告)日：2015-08-04

申请号：US13863817

申请日：2013-04-16

申请人： Unhwa Corporation

发明人： Mi Ok Jang ,  Min Jung Lim ,  Il Seok Oh ,  Dae Hee Lee ,  Eun Kyong Lee ,  Young Woo Jin

IPC分类号： A61K36/25 ,  A61K8/97 ,  A61Q19/08 ,  A61Q19/00

CPC分类号： A61K8/97 ,  A61K2800/522 ,  A61Q19/004 ,  A61Q19/08

摘要： The present invention relates to an anti-aging or antioxidant composition which contains, as an active ingredient, a plant stem cell line derived from the cambium of Panax ginseng, including wild ginseng and ginseng, or an extract thereof, a lysate thereof and a culture thereof. The composition has minimized side effects compared to existing anti-aging agents and antioxidants, and thus is safe for the skin. Also, the composition of the present invention shows an antioxidant effect of inhibiting reactive oxygen species caused by exposure to UV radiation that is the major cause of skin aging, and it can effectively reduce or inhibit aging-related factors. Thus, the composition is useful for the prevention and inhibition of aging.

摘要翻译： 本发明涉及一种抗老化或抗氧化剂组合物，其含有源自人参人参和人参的形成层的植物干细胞系作为活性成分，或其提取物，其裂解物和培养物 其中。 与现有的抗老化剂和抗氧化剂相比，该组合物具有最小的副作用，因此对于皮肤是安全的。 此外，本发明的组合物显示出由于暴露于作为皮肤老化的主要原因的紫外线辐射引起的活性氧的抑制作用，并且可以有效地降低或抑制与老化有关的因素。 因此，该组合物可用于预防和抑制老化。

公开(公告)号：US20130302287A1

公开(公告)日：2013-11-14

申请号：US13863817

申请日：2013-04-16

申请人： Unhwa Corporation

发明人： Mi Ok Jang ,  Min Jung Lim ,  Il Seok Oh ,  Dae Hee Lee ,  Eun Kyong Lee ,  Young Woo Jin

IPC分类号： A61K8/97

CPC分类号： A61K8/97 ,  A61K2800/522 ,  A61Q19/004 ,  A61Q19/08

摘要： The present invention relates to an anti-aging or antioxidant composition which contains, as an active ingredient, a plant stem cell line derived from the cambium of Panax ginseng, including wild ginseng and ginseng, or an extract thereof, a lysate thereof and a culture thereof. The composition has minimized side effects compared to existing anti-aging agents and antioxidants, and thus is safe for the skin. Also, the composition of the present invention shows an antioxidant effect of inhibiting reactive oxygen species caused by exposure to UV radiation that is the major cause of skin aging, and it can effectively reduce or inhibit aging-related factors. Thus, the composition is useful for the prevention and inhibition of aging.

摘要翻译： 本发明涉及一种抗老化或抗氧化剂组合物，其含有源自人参人参和人参的形成层的植物干细胞系作为活性成分，或其提取物，其裂解物和培养物 其中。 与现有的抗老化剂和抗氧化剂相比，该组合物的副作用最小化，因此对皮肤是安全的。 此外，本发明的组合物显示出由于暴露于作为皮肤老化的主要原因的紫外线辐射引起的活性氧的抑制作用，并且可以有效地降低或抑制与老化有关的因素。 因此，该组合物可用于预防和抑制老化。

公开(公告)号：US09415081B2

公开(公告)日：2016-08-16

申请号：US13803963

申请日：2013-03-14

申请人： UNHWA CORPORATION

发明人： Sun Mi Hong ,  Eun Kyong Lee ,  Young Woo Jin

IPC分类号： C12N5/04 ,  A61K36/258 ,  A01H4/00 ,  A23L1/30

CPC分类号： A61K36/258 ,  A01H4/005 ,  A23L33/10 ,  A23L33/105 ,  A23V2002/00 ,  C12N5/04 ,  A23V2200/30 ,  A23V2250/2124

摘要： The present invention relates to a composition for preventing or treating acquired immunodeficiency syndrome (AIDS), comprising one or more of the following: a homogenous cell line, and a lysate, an extract and a culture thereof as an active ingredient. The homogenous cell line, the lysate, the extract and the culture thereof, which are derived from a natural product, minimize adverse side effects of prior therapeutic agents and safe for the human body. Further, they effectively increase the count of T cells such as CD4+ T cells and decrease the number of HIVs, thereby preventing opportunistic infection, dysneuria, and neoplaia caused by immune incompetence, and ultimately the risk of death. Therefore, they are useful in preventing and treating AIDS, and relieving symptoms of AIDS.

摘要翻译： 本发明涉及用于预防或治疗获得性免疫缺陷综合征（AIDS）的组合物，其包含以下一种或多种：均质细胞系，其裂解物，提取物和培养物作为活性成分。 衍生自天然产物的均质细胞系，裂解物，提取物和培养物使得现有治疗剂的不良副作用最小化并对人体安全。 此外，它们有效地增加了T细胞如CD4 + T细胞的数量，并减少了HIV的数量，从而防止了免疫功能不全引起的机会感染，排尿困难和赘生物，最终导致死亡风险。 因此，它们有助于预防和治疗艾滋病，缓解艾滋病的症状。

公开(公告)号：US09289457B2

公开(公告)日：2016-03-22

申请号：US13863829

申请日：2013-04-16

申请人： UNHWA Corporation

发明人： Young Woo Jin ,  Eun Kyong Lee ,  Min Jung Lim

IPC分类号： A61K36/00 ,  A61K36/258 ,  A61K36/25 ,  A01H4/00 ,  A23L1/30 ,  C12N5/04

CPC分类号： A61K36/258 ,  A01H4/005 ,  A23L33/105 ,  A61K36/25 ,  C12N5/04

摘要： The present invention relates to a composition for preventing or treating liver diseases, which contains, as an active ingredient, any one or more of a homogeneous cell line derived from the cambium of Panax ginseng, including wild ginseng or ginseng, a lysate thereof, an extract thereof and a culture medium thereof. The homogeneous cell line according to the present invention, a lysate thereof, an extract thereof and a culture medium thereof have minimized side effects compared to existing agents for treating liver diseases, and thus are safe for the human body. Also, they can increase the levels of s-antibody (HBsAb) and e-antibody (HBeAb) against hepatitis virus and inhibit the proliferation of hepatitis virus, and thus they are useful for the prevention and treatment of liver diseases. In addition, they have the effect of lowering the levels of liver injury, and thus are useful as a functional food for improving liver function.

摘要翻译： 本发明涉及一种预防或治疗肝病的组合物，其含有源自人参的人参或人参的形成层的均质细胞系中的任何一种或多种作为活性成分，其裂解物， 提取物及其培养基。 根据本发明的均相细胞系，其裂解物，其提取物和培养基与现有用于治疗肝脏疾病的药剂相比具有最小的副作用，因此对人体是安全的。 此外，它们可以增加针对肝炎病毒的s-抗体（HBsAb）和e-抗体（HBeAb）的水平，并抑制肝炎病毒的增殖，从而可用于预防和治疗肝脏疾病。 此外，它们具有降低肝损伤水平的作用，因此可用作改善肝功能的功能性食物。

公开(公告)号：US20130315877A1

公开(公告)日：2013-11-28

申请号：US13755517

申请日：2013-01-31

申请人： UNHWA CORPORATION

发明人： JOONG HYUN PARK ,  MIN JUNG LIM ,  IL SEOK OH ,  DAE HEE LEE ,  JUNG CHANG LEE ,  EUN KYONG LEE ,  YOUNG WOO JIN

IPC分类号： A61K36/13

CPC分类号： A61K36/13

摘要： The present invention relates to a composition for preventing or treating cancer, which contains, as an active ingredient, a Taxus cambium- or procambium-derived cell line; a lysate thereof; an extract thereof; or a culture medium thereof. The cell line, the lysate, the extract, and the culture medium has minimized side effects compared to the conventional therapeutic drugs, is safe to the human body, is involved directly in the growth of cancer to induce cancer cell death, and shows anticancer activity of inhibiting angiogenesis occurring in carcinogenesis. Accordingly, the cell line, the lysate, the extract and the culture medium is useful for the prevention, treatment and alleviation of cancer.

摘要翻译： 本发明涉及一种用于预防或治疗癌症的组合物，其含有作为有效成分的红豆杉形成层或原生动物来源的细胞系; 其裂解物; 其提取物; 或其培养基。 细胞系，裂解物，提取物和培养基与常规治疗药物相比具有最小化的副作用，对人体是安全的，直接参与癌症的生长以诱导癌细胞死亡，并且显示抗癌活性 抑制致癌作用中发生的血管生成。 因此，细胞系，裂解物，提取物和培养基可用于预防，治疗和缓解癌症。

公开(公告)号：US20130202631A1

公开(公告)日：2013-08-08

申请号：US13863829

申请日：2013-04-16

申请人： UNHWA Corporation

发明人： Young Woo Jin ,  Eun Kyong Lee ,  Min Jung Lim

IPC分类号： A61K36/258

CPC分类号： A61K36/258 ,  A01H4/005 ,  A23L33/105 ,  A61K36/25 ,  C12N5/04

摘要： The present invention relates to a composition for preventing or treating liver diseases, which contains, as an active ingredient, any one or more of a homogeneous cell line derived from the cambium of Panax ginseng, including wild ginseng or ginseng, a lysate thereof, an extract thereof and a culture medium thereof. The homogeneous cell line according to the present invention, a lysate thereof, an extract thereof and a culture medium thereof have minimized side effects compared to existing agents for treating liver diseases, and thus are safe for the human body. Also, they can increase the levels of s-antibody (HBsAb) and e-antibody (HBeAb) against hepatitis virus and inhibit the proliferation of hepatitis virus, and thus they are useful for the prevention and treatment of liver diseases. In addition, they have the effect of lowering the levels of liver injury, and thus are useful as a functional food for improving liver function.

摘要翻译： 本发明涉及一种预防或治疗肝病的组合物，其含有源自人参的人参或人参的形成层的均质细胞系中的任何一种或多种作为活性成分，其裂解物， 提取物及其培养基。 根据本发明的均相细胞系，其裂解物，其提取物和培养基与现有用于治疗肝脏疾病的药剂相比具有最小的副作用，因此对人体是安全的。 此外，它们可以增加针对肝炎病毒的s-抗体（HBsAb）和e-抗体（HBeAb）的水平，并抑制肝炎病毒的增殖，从而可用于预防和治疗肝脏疾病。 此外，它们具有降低肝损伤水平的作用，因此可用作改善肝功能的功能性食物。