公开(公告)号：US20210269573A1

公开(公告)日：2021-09-02

申请号：US17257969

申请日：2019-07-04

申请人： BASF SE ,  Universidad del Paìs Vasco / Euskal Herriko Unibertsitatea

发明人： Massimo BANDIERA ,  Roelof BALK ,  Bastiaan LOHMEIJER ,  Maria Jesus BARANDIARAN

IPC分类号： C08F265/06 ,  C09D151/00 ,  C08J3/07

摘要： The present invention relates to a process for producing an aqueous polymer dispersion of polymerized ethylenically unsaturated monomers, where the process has a first polymerization step as an aqueous radical emulsion polymerization of a first monomer composition M.a and a subsequent further polymerization step as an aqueous radical emulsion polymerization of a second monomer composition M.b,
where the monomers M comprise at least one monomer M0 which is selected from compounds of formula 1, wherein X is Cl, Br or OS(O)2R3, Y is H, Cl, Br, OS(O)2R4, C1-C10-alkyl, or C(═O)OR5, R1 is H or C1-C10-alkyl, R2 is H or C1-C10-alkyl, R3 is C1-C10-alkyl, R4 is C1-C10-alkyl, R5 is C1-C20-alkyl. The invention also relates to an aqueous polymer dispersion obtainable by such a process as well as the use of such dispersions.

公开(公告)号：US11999810B2

公开(公告)日：2024-06-04

申请号：US17257969

申请日：2019-07-04

申请人： BASF SE ,  Universidad del Paìs Vasco / Euskal Herriko Unibertsitatea

发明人： Massimo Bandiera ,  Roelof Balk ,  Bastiaan Lohmeijer ,  Maria Jesus Barandiaran

IPC分类号： C08J3/07 ,  C08F265/06 ,  C09D151/00

CPC分类号： C08F265/06 ,  C08J3/07 ,  C09D151/003 ,  C08J2351/00 ,  C08F265/06 ,  C08F220/1804

摘要： The present invention relates to a process for producing an aqueous polymer dispersion of polymerized ethylenically unsaturated monomers, where the process has a first polymerization step as an aqueous radical emulsion polymerization of a first monomer composition M.a and a subsequent further polymerization step as an aqueous radical emulsion polymerization of a second monomer composition M.b,
where the monomers M comprise at least one monomer M0 which is selected from compounds of formula 1, wherein X is Cl, Br or OS(O)2R3, Y is H, Cl, Br, OS(O)2R4, C1-C10-alkyl, or C(═O)OR5, R1 is H or C1-C10-alkyl, R2 is H or C1-C10-alkyl, R3 is C1-C10-alkyl, R4 is C1-C10-alkyl, R5 is C1-C20-alkyl.




The invention also relates to an aqueous polymer dispersion obtainable by such a process as well as the use of such dispersions.

公开(公告)号：US20170281662A1

公开(公告)日：2017-10-05

申请号：US15627607

申请日：2017-06-20

申请人： International Business Machines Corporation ,  Agency For Science, Technology and Research ,  Universidad del PaÌs Vasco/Euskal Herriko Unibertsitatea

发明人： Julian M. W. Chan ,  Amanda C. Engler ,  James L. Hedrick ,  Haritz Sardon ,  Jeremy P. K. Tan ,  Yi Yan Yang

IPC分类号： A61K31/704 ,  A61K31/713 ,  A61K9/51

CPC分类号： A61K47/34 ,  A61K9/5146 ,  A61K31/704 ,  A61K31/713 ,  A61K38/00 ,  A61K38/16 ,  C08G64/0241 ,  C08G64/183 ,  C08L69/00

摘要： Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.