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公开(公告)号：US20080193490A1
公开(公告)日：2008-08-14
申请号：US11841087
申请日：2007-08-20
CPC分类号： B82Y30/00 , A61K9/0092 , A61K47/6949 , A61K49/0004 , B82Y5/00
摘要： Compositions and methods for administering a therapeutic agent to a mammal are disclosed. The compositions comprise either (i) vesicles comprising an amphiphilic substituted fullerene, wherein the therapeutic agent is present in the vesicle interior or between layers of the vesicle wall, (ii) a substituted fullerene, comprising a fullerene core and a functional moiety, wherein the therapeutic agent is associated with the substituted fullerene, or (iii) carbon nanotubes, wherein the therapeutic agent is associated with the carbon nanotubes.
摘要翻译： 公开了向哺乳动物施用治疗剂的组合物和方法。 所述组合物包含（i）包含两亲性取代的富勒烯的囊泡，其中所述治疗剂存在于泡囊内部或囊泡壁的层之间，（ii）包含富勒烯核心和功能部分的取代的富勒烯，其中 治疗剂与取代的富勒烯相关，或（iii）碳纳米管，其中治疗剂与碳纳米管相关联。
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公开(公告)号：US20110045031A1
公开(公告)日：2011-02-24
申请号：US12876695
申请日：2010-09-07
申请人： Andreas Hirsch , Uri Sagman , Stephen R. Wilson
发明人： Andreas Hirsch , Uri Sagman , Stephen R. Wilson
CPC分类号： A61K9/127 , A61K9/0092 , A61K47/6923 , A61K47/6925 , A61K47/6949 , A61K49/0004 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/152 , C01B32/174
摘要： Compositions and methods for administering a therapeutic agent to a mammal are disclosed. The compositions comprise either (i) vesicles comprising an amphiphilic substituted fullerene, wherein the therapeutic agent is present in the vesicle interior or between layers of the vesicle wall, (ii) a substituted fullerene, comprising a fullerene core and a functional moiety, wherein the therapeutic agent is associated with the substituted fullerene, or (iii) carbon nanotubes, wherein the therapeutic agent is covalently bonded to the carbon nanotubes.
摘要翻译： 公开了向哺乳动物施用治疗剂的组合物和方法。 所述组合物包含（i）包含两亲性取代的富勒烯的囊泡，其中所述治疗剂存在于泡囊内部或囊泡壁的层之间，（ii）包含富勒烯核心和功能部分的取代的富勒烯，其中 治疗剂与取代的富勒烯相关，或（iii）碳纳米管，其中治疗剂与碳纳米管共价键合。
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公开(公告)号：US20060127470A1
公开(公告)日：2006-06-15
申请号：US11347906
申请日：2006-02-06
申请人： Andreas Hirsch , Uri Sagman , Stephen Wilson
发明人： Andreas Hirsch , Uri Sagman , Stephen Wilson
IPC分类号： A61K9/127 , A61K31/195
CPC分类号： B82Y30/00 , A61K47/6949 , A61K49/0004 , B82Y5/00 , Y10S516/901 , Y10S977/734 , Y10T428/1352 , Y10T428/1393
摘要： Compositions and methods for administering a therapeutic agent to a mammal are disclosed. The compositions comprise either (i) vesicles comprising an amphiphilic substituted fullerene, wherein the therapeutic agent is present in the vesicle interior or between layers of the vesicle wall, (ii) a substituted fullerene, comprising a fullerene core and a functional moiety, wherein the therapeutic agent is associated with the substituted fullerene, or (iii) carbon nanotubes, wherein the therapeutic agent is covalently bonded to the carbon nanotubes.
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公开(公告)号：US20080003293A1
公开(公告)日：2008-01-03
申请号：US11678146
申请日：2007-02-23
申请人： Andreas Hirsch , Uri Sagman , Stephen Wilson
发明人： Andreas Hirsch , Uri Sagman , Stephen Wilson
CPC分类号： A61K9/127 , A61K9/0092 , A61K47/6923 , A61K47/6925 , A61K47/6949 , A61K49/0004 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/152 , C01B32/174
摘要： Compositions and methods for administering a therapeutic agent to a mammal are disclosed. The compositions comprise either (i) vesicles comprising an amphiphilic substituted fullerene, wherein the therapeutic agent is present in the vesicle interior or between layers of the vesicle wall, (ii) a substituted fullerene, comprising a fullerene core and a functional moiety, wherein the therapeutic agent is associated with the substituted fullerene, or (iii) carbon nanotubes, wherein the therapeutic agent is covalently bonded to the carbon nanotubes.
摘要翻译： 公开了向哺乳动物施用治疗剂的组合物和方法。 所述组合物包含（i）包含两亲性取代的富勒烯的囊泡，其中所述治疗剂存在于泡囊内部或囊泡壁的层之间，（ii）包含富勒烯核心和功能部分的取代的富勒烯，其中 治疗剂与取代的富勒烯相关，或（iii）碳纳米管，其中治疗剂与碳纳米管共价键合。
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公开(公告)号：US07070810B2
公开(公告)日：2006-07-04
申请号：US10367646
申请日：2003-02-14
申请人： Andreas Hirsch , Uri Sagman , Stephen R. Wilson
发明人： Andreas Hirsch , Uri Sagman , Stephen R. Wilson
CPC分类号： B82Y30/00 , A61K47/6949 , A61K49/0004 , B82Y5/00 , Y10S516/901 , Y10S977/734 , Y10T428/1352 , Y10T428/1393
摘要： Compositions and methods for administering a therapeutic agent to a mammal are disclosed. The compositions comprise either (i) vesicles comprising an amphiphilic substituted fullerene, wherein the therapeutic agent is present in the vesicle interior or between layers of the vesicle wall, (ii) a substituted fullerene, comprising a fullerene core and a functional moiety, wherein the therapeutic agent is associated with the substituted fullerene, or (iii) carbon nanotubes, wherein the therapeutic agent is covalently bonded to the carbon nanotubes.
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公开(公告)号：US20110130580A1
公开(公告)日：2011-06-02
申请号：US12274089
申请日：2008-11-19
申请人： Andreas Hirsch , Uri Sagman , Stephen R. Wilson
发明人： Andreas Hirsch , Uri Sagman , Stephen R. Wilson
CPC分类号： A61K9/127 , A61K9/0092 , A61K47/6923 , A61K47/6925 , A61K47/6949 , A61K49/0004 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/152 , C01B32/174
摘要： Compositions and methods for administering a therapeutic agent to a mammal are disclosed. The compositions comprise either (i) vesicles comprising an amphiphilic substituted fullerene, wherein the therapeutic agent is present in the vesicle interior or between layers of the vesicle wall, (ii) a substituted fullerene, comprising a fullerene core and a functional moiety, wherein the therapeutic agent is associated with the substituted fullerene, or (iii) carbon nanotubes, wherein the therapeutic agent is covalently bonded to the carbon nanotubes.
摘要翻译： 公开了向哺乳动物施用治疗剂的组合物和方法。 所述组合物包含（i）包含两亲性取代的富勒烯的囊泡，其中所述治疗剂存在于泡囊内部或囊泡壁的层之间，（ii）包含富勒烯核心和功能部分的取代的富勒烯，其中 治疗剂与取代的富勒烯相关，或（iii）碳纳米管，其中治疗剂与碳纳米管共价键合。
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公开(公告)号：US07758889B1
公开(公告)日：2010-07-20
申请号：US10623110
申请日：2003-07-18
申请人： Uri Sagman , Michael G. Rosenblum , Lon J. Wilson
发明人： Uri Sagman , Michael G. Rosenblum , Lon J. Wilson
CPC分类号： A61K31/337 , A61K47/6855 , A61K47/6865 , A61K2039/505 , C07K16/3053 , C07K2317/622
摘要： Herein we disclose a composition, comprising a Cn-Ab, wherein Cn is a fullerene or nanotube comprising n carbon atoms, and Ab is a moiety comprising an antigen-binding site and is linked to the Cn. The composition can further comprise a therapeutic molecule associated with the Cn-Ab. Also, we disclose a method of treating a disease in a mammal, comprising administering to the mammal an effective amount of the composition.
摘要翻译： 在本文中，我们公开了包含Cn-Ab的组合物，其中C n是包含n个碳原子的富勒烯或纳米管，Ab是包含抗原结合位点并与Cn连接的部分。 组合物还可以包含与Cn-Ab相关的治疗分子。 此外，我们公开了一种治疗哺乳动物疾病的方法，包括向哺乳动物施用有效量的组合物。
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8.发明授权公开(公告)号：US06660248B2
公开(公告)日：2003-12-09
申请号：US10038075
申请日：2001-11-09
申请人： Lon J. Wilson , John T. Wharton , Uri Sagman
发明人： Lon J. Wilson , John T. Wharton , Uri Sagman
IPC分类号： A61K5100
CPC分类号： B82Y15/00 , A61K47/6949 , A61K49/0447 , B82Y5/00 , Y10S516/901 , Y10S977/835 , Y10S977/928
摘要： An contrast agent for therapeutic or diagnostic treatment comprises a fullerene scaffold and an iodinated moiety bonded to the scaffold. The agent may further comprise a water solubilizing moiety bonded to the scaffold, which may be a serinol malonodiamide, hydroxyl, and 1,3-diol. The fullerene scaffold may comprise an empty fullerene or an endohedral fullerene. A method for making the agent includes a) synthesizing iodinating moieties, b) protecting serinols, forming protected serinols, c) attaching the protected serinols to the iodinated moieties, forming iodinated serinols, d) attaching the iodinated serinols to the fullerene scaffold, and, optionally, d) de-protecting the serinols. Also disclosed are a method for providing diagnostic treatment to a patient comprising administering to said patient a radiopaque effective amount of a contrast agent comprising a fullerene scaffold and an iodinated moiety, a method of making a blood pool agent.
摘要翻译： 用于治疗或诊断治疗的造影剂包括富勒烯支架和结合到支架的碘化部分。 该试剂还可以包含结合到支架上的水溶性部分，其可以是丝氨醇壬二酰胺，羟基和1,3-二醇。 富勒烯支架可以包括空的富勒烯或内嵌的富勒烯。 制备该试剂的方法包括：a）合成碘化部分，b）保护丝氨醇，形成受保护的丝氨醇，c）将被保护的丝氨醇连接到碘化部分，形成碘化丝氨醇，d）将碘化丝氨醇连接到富勒烯支架上， 任选地，d）脱保护丝氨醇。 还公开了一种向患者提供诊断治疗的方法，包括向所述患者施用不透射线的有效量的包含富勒烯支架和碘化部分的造影剂，制备血液池剂的方法。
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