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公开(公告)号：US20080193490A1
公开(公告)日：2008-08-14
申请号：US11841087
申请日：2007-08-20
CPC分类号： B82Y30/00 , A61K9/0092 , A61K47/6949 , A61K49/0004 , B82Y5/00
摘要： Compositions and methods for administering a therapeutic agent to a mammal are disclosed. The compositions comprise either (i) vesicles comprising an amphiphilic substituted fullerene, wherein the therapeutic agent is present in the vesicle interior or between layers of the vesicle wall, (ii) a substituted fullerene, comprising a fullerene core and a functional moiety, wherein the therapeutic agent is associated with the substituted fullerene, or (iii) carbon nanotubes, wherein the therapeutic agent is associated with the carbon nanotubes.
摘要翻译： 公开了向哺乳动物施用治疗剂的组合物和方法。 所述组合物包含（i）包含两亲性取代的富勒烯的囊泡，其中所述治疗剂存在于泡囊内部或囊泡壁的层之间，（ii）包含富勒烯核心和功能部分的取代的富勒烯，其中 治疗剂与取代的富勒烯相关，或（iii）碳纳米管，其中治疗剂与碳纳米管相关联。
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公开(公告)号：US07758889B1
公开(公告)日：2010-07-20
申请号：US10623110
申请日：2003-07-18
申请人： Uri Sagman , Michael G. Rosenblum , Lon J. Wilson
发明人： Uri Sagman , Michael G. Rosenblum , Lon J. Wilson
CPC分类号： A61K31/337 , A61K47/6855 , A61K47/6865 , A61K2039/505 , C07K16/3053 , C07K2317/622
摘要： Herein we disclose a composition, comprising a Cn-Ab, wherein Cn is a fullerene or nanotube comprising n carbon atoms, and Ab is a moiety comprising an antigen-binding site and is linked to the Cn. The composition can further comprise a therapeutic molecule associated with the Cn-Ab. Also, we disclose a method of treating a disease in a mammal, comprising administering to the mammal an effective amount of the composition.
摘要翻译： 在本文中，我们公开了包含Cn-Ab的组合物，其中C n是包含n个碳原子的富勒烯或纳米管，Ab是包含抗原结合位点并与Cn连接的部分。 组合物还可以包含与Cn-Ab相关的治疗分子。 此外，我们公开了一种治疗哺乳动物疾病的方法，包括向哺乳动物施用有效量的组合物。
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3.发明授权公开(公告)号：US06660248B2
公开(公告)日：2003-12-09
申请号：US10038075
申请日：2001-11-09
申请人： Lon J. Wilson , John T. Wharton , Uri Sagman
发明人： Lon J. Wilson , John T. Wharton , Uri Sagman
IPC分类号： A61K5100
CPC分类号： B82Y15/00 , A61K47/6949 , A61K49/0447 , B82Y5/00 , Y10S516/901 , Y10S977/835 , Y10S977/928
摘要： An contrast agent for therapeutic or diagnostic treatment comprises a fullerene scaffold and an iodinated moiety bonded to the scaffold. The agent may further comprise a water solubilizing moiety bonded to the scaffold, which may be a serinol malonodiamide, hydroxyl, and 1,3-diol. The fullerene scaffold may comprise an empty fullerene or an endohedral fullerene. A method for making the agent includes a) synthesizing iodinating moieties, b) protecting serinols, forming protected serinols, c) attaching the protected serinols to the iodinated moieties, forming iodinated serinols, d) attaching the iodinated serinols to the fullerene scaffold, and, optionally, d) de-protecting the serinols. Also disclosed are a method for providing diagnostic treatment to a patient comprising administering to said patient a radiopaque effective amount of a contrast agent comprising a fullerene scaffold and an iodinated moiety, a method of making a blood pool agent.
摘要翻译： 用于治疗或诊断治疗的造影剂包括富勒烯支架和结合到支架的碘化部分。 该试剂还可以包含结合到支架上的水溶性部分，其可以是丝氨醇壬二酰胺，羟基和1,3-二醇。 富勒烯支架可以包括空的富勒烯或内嵌的富勒烯。 制备该试剂的方法包括：a）合成碘化部分，b）保护丝氨醇，形成受保护的丝氨醇，c）将被保护的丝氨醇连接到碘化部分，形成碘化丝氨醇，d）将碘化丝氨醇连接到富勒烯支架上， 任选地，d）脱保护丝氨醇。 还公开了一种向患者提供诊断治疗的方法，包括向所述患者施用不透射线的有效量的包含富勒烯支架和碘化部分的造影剂，制备血液池剂的方法。
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公开(公告)号：US20080175892A1
公开(公告)日：2008-07-24
申请号：US11841524
申请日：2007-08-20
IPC分类号： A61K9/127 , A61K47/42 , A61K9/12 , A61P35/00 , A61K31/337
CPC分类号： A61K31/337 , A61K9/0078 , A61K9/127 , A61K47/6949 , B82Y5/00
摘要： Nanostructure-drug conjugates and associated methods of use are provided. In one embodiment, a nanostructure-drug conjugate comprising a Cn, a crosslinker, and a drug is provided, wherein Cn refers to a fullerene moiety or nanotube comprising n carbon atoms. A method of treating cancer is also provided, comprising administering a therapeutically effective amount of a nanostructure-drug conjugate comprising: a Cn, a crosslinker, and a drug, wherein Cn refers to a fullerene moiety comprising n carbon atoms to a mammal.
摘要翻译： 提供了纳米结构 - 药物共轭物和相关使用方法。 在一个实施方案中，提供了包含C n N，交联剂和药物的纳米结构药物缀合物，其中C n是指包含n碳的富勒烯部分或纳米管 原子 还提供了一种治疗癌症的方法，包括施用治疗有效量的纳米结构 - 药物缀合物，其包含：C n N，交联剂和药物，其中C n 指向哺乳动物包含n个碳原子的富勒烯部分。
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公开(公告)号：US20090214101A1
公开(公告)日：2009-08-27
申请号：US12325849
申请日：2008-12-01
IPC分类号： G06K9/00 , C07K16/18 , G01N33/483
CPC分类号： A61K49/16 , A61K47/60 , A61K49/085
摘要： Compositions and methods related to targeted carbon nanostructures. More particularly, targeted carbon nanostructures comprising: a Cn, a cross-linker, and a targeting agent, wherein Cn refers to a fullerene moiety or nanotube comprising n carbon atoms. One example of a method may involve a method for imaging comprising: contacting a targeted carbon nanostructure and a cell; allowing the cell to internalize the carbon nanostructure; and detecting the presence of internalized carbon nanostructures.
摘要翻译： 与目标碳纳米结构相关的组成和方法。 更具体地，包括Cn，交联剂和靶向剂的靶向碳纳米结构，其中C n是指包含n个碳原子的富勒烯部分或纳米管。 方法的一个实例可以包括用于成像的方法，其包括：使目标碳纳米结构和细胞接触; 使细胞内化碳纳米结构; 并检测内在碳纳米结构的存在。
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公开(公告)号：US20060051290A1
公开(公告)日：2006-03-09
申请号：US11180088
申请日：2005-07-13
CPC分类号： B82Y30/00 , A61K49/1884 , A61K51/1251 , B82Y5/00 , Y10T428/2935
摘要： A method for delivering a radiotherapeutic agent to a target, comprises administering a composition comprising water-soluble nanotubes having an average length less than 50 nm and a radionuclide so as to expose the target to the composition. The nanotubes can be functionalized with a monoclonal antibody having an affinity for the target. The radionuclide can be contained in the nanotubes, which can be derivatized. The nanotubes can be loaded with I2 or 211AtI, another α-emitter, including but not limited to 211AtI, 225Ac, 212Bi, 213Bi, and combinations thereof. The nanotubes have an average length less than 40 nm, or an average length less than 30 nm.
摘要翻译： 将放射治疗剂递送至靶的方法包括施用包含平均长度小于50nm的水溶性纳米管和放射性核素的组合物，以将靶暴露于组合物。 纳米管可以用对靶具有亲和性的单克隆抗体进行功能化。 放射性核素可以包含在可以衍生的纳米管中。 纳米管可以加载另一个α发射体，其中包括但不限于二级，二级，二级，二级，二级， Bi，Bi，Bi，Bi，Bi及其组合。 纳米管的平均长度小于40nm，平均长度小于30nm。
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公开(公告)号：US20120189492A1
公开(公告)日：2012-07-26
申请号：US13380606
申请日：2010-06-24
申请人： Pedro J.J. Alvarez , Jaesang Lee , Lon J. Wilson , Yuri Mackeyev , Jaehong Kim
发明人： Pedro J.J. Alvarez , Jaesang Lee , Lon J. Wilson , Yuri Mackeyev , Jaehong Kim
IPC分类号： A61L2/10 , C07D265/30 , C07C233/16 , B01J19/08 , C07F7/08 , A61L2/08 , C07C55/02 , C07C229/04 , B82Y99/00 , B82Y30/00
摘要： In various embodiments, the present disclosure describes fullerene derivatives that are capable of photocatalytically generating reactive oxygen species in the presence of ultraviolet and/or visible light. In some embodiments, the fullerene derivatives are aminofullerenes containing a plurality of amine-terminated moieties covalently bonded to the fullerene cage. The fullerene derivatives may optionally be covalently bonded to a substrate surface for use in photocatalytic disinfection systems for removing various contaminants including, for example, bacteria, viruses, protozoa and chemical pollutants. Methods using the present fullerene and aminofullerene derivatives in various purification processes are also described herein.
摘要翻译： 在各种实施方案中，本公开描述了在紫外线和/或可见光存在下能够光催化产生活性氧的富勒烯衍生物。 在一些实施方案中，富勒烯衍生物是含有共价键合到富勒烯笼上的多个胺封端部分的氨基富勒烯。 富勒烯衍生物可以任选地共价结合到基底表面，用于光催化消毒系统中，用于除去诸如细菌，病毒，原生动物和化学污染物的各种污染物。 本文还描述了在各种纯化方法中使用本发明富勒烯和氨基富勒烯衍生物的方法。
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公开(公告)号：US08986942B2
公开(公告)日：2015-03-24
申请号：US13473120
申请日：2012-05-16
CPC分类号： A61K51/00 , A61K49/0409 , A61K49/0447 , B82Y5/00
摘要： Compositions and methods related to carbon nanotubes are provided. More particularly, imaging agents comprising carbon nanotubes internally loaded with a contrast agent and associated methods are provided. One example of a method may involve a method for imaging comprising: providing an imaging agent comprising a carbon nanotube loaded with contrast agent; introducing the imaging agent into a cell; and imaging the cell to detect the presence of the imaging agent.
摘要翻译： 提供了与碳纳米管相关的组成和方法。 更具体地，提供了包含内部装有造影剂的碳纳米管和相关方法的成像剂。 方法的一个实例可以涉及一种用于成像的方法，其包括：提供包含负载有造影剂的碳纳米管的成像剂; 将成像剂引入细胞中; 并对细胞成像以检测成像剂的存在。
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公开(公告)号：US20130130295A1
公开(公告)日：2013-05-23
申请号：US13473120
申请日：2012-05-16
IPC分类号： A61K51/00
CPC分类号： A61K51/00 , A61K49/0409 , A61K49/0447 , B82Y5/00
摘要： Compositions and methods related to carbon nanotubes are provided. More particularly, imaging agents comprising carbon nanotubes internally loaded with a contrast agent and associated methods are provided. One example of a method may involve a method for imaging comprising: providing an imaging agent comprising a carbon nanotube loaded with contrast agent; introducing the imaging agent into a cell; and imaging the cell to detect the presence of the imaging agent.
摘要翻译： 提供了与碳纳米管相关的组成和方法。 更具体地，提供了包含内部装有造影剂的碳纳米管的成像剂和相关方法。 方法的一个实例可以涉及一种用于成像的方法，其包括：提供包含负载有造影剂的碳纳米管的成像剂; 将成像剂引入细胞中; 并对细胞成像以检测成像剂的存在。
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10.发明授权公开(公告)号：US08128901B2
公开(公告)日：2012-03-06
申请号：US12299691
申请日：2007-05-07
申请人： Yuri Mackeyev , Lon J. Wilson
发明人： Yuri Mackeyev , Lon J. Wilson
IPC分类号： C01B37/02
CPC分类号： B82Y30/00 , B82Y40/00 , C01B32/17 , C01B2202/02 , C01B2202/04 , C01B2202/06 , Y10S977/752
摘要： A method of removing metal impurities from carbon nanotubes includes treating carbon nanotubes with distilled bromine in a substantially oxygen- and water-free atmosphere and then removing the distilled bromine from the carbon nanotubes. Purified carbon nanotubes having an iron content from about 2.5 to about 3.5 by weight that are substantially free of derivatization at the ends and defect sites are made available via this method.
摘要翻译： 从碳纳米管除去金属杂质的方法包括在基本上无氧和无水的气氛中用蒸馏的溴处理碳纳米管，然后从碳纳米管中除去蒸馏的溴。 通过这种方法可以获得铁含量约2.5至约3.5重量％的纯化碳纳米管，其基本上不含末端和缺陷位点的衍生化。
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