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    Epidithiodioxopiperazine compound or its derivatives, and the use thereof
    3.
    发明授权
    Epidithiodioxopiperazine compound or its derivatives, and the use thereof 有权

    公开(公告)号：US10450327B2

    公开(公告)日：2019-10-22

    申请号：US16024454

    申请日：2018-06-29

    Applicant: VASTHERA Co. Ltd.

    Inventor： Sang Won Kang ,  Dong Hoon Kang ,  Doo Jae Lee

    IPC: C07D513/08 ,  C12Q1/26 ,  A61K31/00 ,  A61K31/548

    Abstract: The present invention relates to an epidithiodioxopiperazine derivative represented by the following Chemical Formula 1 or its reduced derivative; a method for preparing a compound represented by Chemical Formula 1 having improved intracellular permeability and mimicking the activity of 2-Cys-Prx in its reduced form in the cells; a pharmaceutical composition for preventing or treating vascular diseases comprising an epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient; a drug delivery device for local administration including the pharmaceutical composition; and a pharmaceutical composition for inhibiting melanoma metastasis comprising the epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient.

    COMPOSITION FOR DIAGNOSIS, PREVENTION, OR TREATMENT OF VASCULAR SMOOTH MUSCLE CELL PROLIFERATIVE DISEASE, USING MIRNA INHIBITOR
    4.
    发明申请
    COMPOSITION FOR DIAGNOSIS, PREVENTION, OR TREATMENT OF VASCULAR SMOOTH MUSCLE CELL PROLIFERATIVE DISEASE, USING MIRNA INHIBITOR 有权

    公开(公告)号：US20250002916A1

    公开(公告)日：2025-01-02

    申请号：US18708953

    申请日：2022-11-09

    Applicant: EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION ,  VASTHERA CO. LTD.

    Inventor： Sang Won KANG ,  Sang-Hyuk LEE ,  Yerin KIM

    IPC: C12N15/113 ,  C12Q1/6851 ,  C12Q1/6883

    Abstract: The present invention relates to a pharmaceutical composition comprising a microRNA (miRNA) inhibitor as an active ingredient for the prevention or treatment of a vascular smooth muscle cell proliferative disease; a kit comprising a miRNA-detectable agent for the diagnosis of a vascular smooth muscle cell proliferative disease; a method for providing information for the diagnosis of the diseases; and a therapeutic method. Discovered in the present invention were the miRNA subsets miR-132-3p, miR-370-3p, miR-130b-5p, and miR-410-3p that are involved in proliferative diseases of smooth muscle cells. It was found that these miRNAs significantly increased their expression 5-fold or more in damaged arteries, compared to the control, and in particular, miR-370-3p was highly expressed in coronary tissues of atherosclerosis patients. Thus, the miRNAs can be advantageously used for diagnosing diseases related thereto and further can find applications in treating vascular smooth muscle cell proliferative diseases.

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