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1.发明公开公开(公告)号：US20240173365A1
公开(公告)日：2024-05-30
申请号：US18574232
申请日：2022-06-28
发明人： Emily Crossette , Bernat Olle
IPC分类号： A61K35/742 , A61K31/606 , A61K35/741 , A61K38/14 , A61P1/04 , C12Q1/6851 , C12Q1/689 , A61K35/00
CPC分类号： A61K35/742 , A61K31/606 , A61K35/741 , A61K38/14 , A61P1/04 , C12Q1/6851 , C12Q1/689 , A61K2035/115
摘要： The disclosure relates to methods for colonizing a microbiome, by administering pharmaceutical compositions comprising a purified bacterial mixture to the subject. Also provided are methods for treating and/or preventing inflammatory bowel disease, methods for reducing the risk of inflammatory bowel disease and/or reducing the occurrence of inflammatory bowel disease in a subject by administering pharmaceutical compositions comprising a purified bacterial mixture to the subject. Also provided are methods for treating and/or preventing graft versus host disease in a subject by administering pharmaceutical compositions comprising a purified bacterial mixture to the subject.
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公开(公告)号：US20240123000A1
公开(公告)日：2024-04-18
申请号：US18326511
申请日：2023-05-31
发明人： Jessica Schneider , Yun-Gi Kim , Bernat Olle , Shilpa Reddy , Jason Norman , Juan Patarroyo
IPC分类号： A61K35/747 , A23L5/00 , A23L33/135 , A61K9/00 , A61K9/48 , A61K35/74 , A61K35/742 , A61K38/14 , C12N1/20
CPC分类号： A61K35/747 , A23L5/00 , A23L33/135 , A61K9/0053 , A61K9/48 , A61K35/74 , A61K35/742 , A61K38/14 , C12N1/20 , A23K10/18
摘要： Provided herein are compositions and methods for the treatment or prevention of pathogenic infections.
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3.发明申请公开(公告)号：US20190134179A1
公开(公告)日：2019-05-09
申请号：US16160869
申请日：2018-10-15
申请人： Vedanta Biosciences, Inc. , Riken
发明人： Kenya Honda , Bernat Olle , Koji Atarashi , Takeshi Tanoue , Hiroshi Ohno , Shinji Fukuda , Koji Hase
摘要： Compositions consisting of bioactive molecules derived from the microbiota of a mammal are provided herein. When administered orally with a colonic delivery system, the compositions are useful for the prophylaxis and treatment of diseases, in particular inflammatory, autoimmune and infectious diseases. The compositions comprise combinations of small molecules and bacterial antigens formulated in colonic delivery systems. Use of the compositions results in any or all of: induction of immune tolerance; strengthening of the gut mucosal barrier integrity; reduction of inflammation; and amelioration of a disease state caused by inflammation, an autoimmune reaction or an infectious agent.
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公开(公告)号：US20180264056A1
公开(公告)日：2018-09-20
申请号：US15993037
申请日：2018-05-30
发明人： Jessica Schneider , Yun-Gi Kim , Bernat Olle , Shilpa Reddy , Jason Norman , Juan Patarroyo
IPC分类号： A61K35/747 , A61K35/742 , A61K35/74 , A61K9/48 , A61K9/00
CPC分类号： A61K35/747 , A23K10/18 , A23K50/30 , A23L5/00 , A23L33/135 , A61K9/0053 , A61K9/48 , A61K35/74 , A61K35/742 , A61K38/14
摘要： Provided herein are compositions and methods for the treatment or prevention of pathogenic infections.
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公开(公告)号：US20240141283A1
公开(公告)日：2024-05-02
申请号：US18476483
申请日：2023-09-28
发明人： Daniel E. Couto , Shilpa Reddy , Jil Ulrich , Scott Michonski
摘要： The disclosure provides methods and compositions for the preservation of bacteria.
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公开(公告)号：US11814615B2
公开(公告)日：2023-11-14
申请号：US17822860
申请日：2022-08-29
发明人： Daniel E. Couto , Shilpa Reddy , Jil Ulrich , Scott Michonski
摘要： The disclosure provides methods and compositions for the preservation of bacteria.
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公开(公告)号：US20220409674A1
公开(公告)日：2022-12-29
申请号：US17633930
申请日：2020-08-07
发明人： Silvia Caballero
IPC分类号： A61K35/741 , A61K35/742 , A61K35/745
摘要： Provided herein are compositions and methods for suppressing pathogenic organisms. Also provided herein are compositions and methods for inducing regulatory T-cells in response to pathogenic organisms and methods of treating a disease or disorder associated with bacterial colonization. Also provided herein are methods of suppressing colonization of the intestine of a subject with oral microbiome bacteria.
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公开(公告)号：US20220389369A1
公开(公告)日：2022-12-08
申请号：US17760674
申请日：2020-09-15
发明人： Scott Michonski
摘要： The disclosure provides methods and compositions for the preservation of bacteria. Aspects of the present disclosure provide methods of preparing a preserved bacterial composition comprising flash freezing a bacterial composition and lyophilizing the flash frozen bacterial composition to produce a preserved bacterial composition. In some embodiments, the bacterial composition comprises one or more bacterial strains. In some embodiments, the one or more bacterial strains comprise one or more anaerobic bacterial strains. In some embodiments, the anaerobic bacterial strains are strict anaerobic bacteria.
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公开(公告)号：US10456431B2
公开(公告)日：2019-10-29
申请号：US16157640
申请日：2018-10-11
发明人： Jessica Schneider , Yun-Gi Kim , Bernat Olle , Shilpa Reddy , Jason Norman , Juan Patarroyo
IPC分类号： A61K35/741 , A61K35/747 , A61K9/00 , A61K35/742 , A61K35/74 , A61K9/48 , A23L5/00 , A23L33/135 , A61K38/14 , A23K10/18 , A23K50/30
摘要： Provided herein are compositions and methods for the treatment or prevention of pathogenic infections.
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10.发明授权公开(公告)号：US10130695B2
公开(公告)日：2018-11-20
申请号：US15680629
申请日：2017-08-18
申请人： Vedanta Biosciences, Inc. , RIKEN
发明人： Kenya Honda , Bernat Olle , Koji Atarashi , Takeshi Tanoue , Hiroshi Ohno , Shinji Fukuda , Koji Hase
IPC分类号： A61K35/741 , A61K39/00 , A61K39/02 , A61K39/08 , A61K31/19 , A61K45/06 , A61K38/16 , G01N33/569
摘要： Compositions consisting of bioactive molecules derived from the microbiota of a mammal are provided herein. When administered orally with a colonic delivery system, the compositions are useful for the prophylaxis and treatment of diseases, in particular inflammatory, autoimmune and infectious diseases. The compositions comprise combinations of small molecules and bacterial antigens formulated in colonic delivery systems. Use of the compositions results in any or all of: induction of immune tolerance; strengthening of the gut mucosal barrier integrity; reduction of inflammation; and amelioration of a disease state caused by inflammation, an autoimmune reaction or an infectious agent.
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