公开(公告)号：US5203782A

公开(公告)日：1993-04-20

申请号：US675295

申请日：1991-03-26

申请人： Vasily F. Gudov ,  Nikolai E. Yakhontov ,  Vladimir P. Kharchenko ,  Boris K. Dolotov ,  Evgeny L. Belousov ,  Valery B. Vinitsky ,  Alexandr M. Kozlov ,  Mikhail G. Akhalaya ,  Alexandr Kovenshnikov ,  Valery F. Pugachev

发明人： Vasily F. Gudov ,  Nikolai E. Yakhontov ,  Vladimir P. Kharchenko ,  Boris K. Dolotov ,  Evgeny L. Belousov ,  Valery B. Vinitsky ,  Alexandr M. Kozlov ,  Mikhail G. Akhalaya ,  Alexandr Kovenshnikov ,  Valery F. Pugachev

IPC分类号： A61F7/00 ,  A61N1/40

CPC分类号： A61N1/406 ,  A61F2007/009

摘要： A method is provided wherein a suspension containing ferromagnetic particles is introduced into a body, and the particles are caused to move towards a tumor and are retained there by a magnetic field. The area of the tumor is exposed to an electromagnetic field to carry out hyperpyrexia of the tumor to a temperature sufficient to kill cancer cells. The contents of the tumor are removed. The condition of a patient's body is monitored during the treatment by determining activity of neutrophils and macrophages. An apparatus is also provided for carrying out the method and comprises an electromagnetic radiation source with emitters, temperature pickups, and a temperature setter connected to inputs of a comparator, a temperature control unit for controlling hyperpyrexia temperature connected to an output of the comparator and forming a signal fed to a control input of the source of radiation. The apparatus is also provided with a magnetic retainer for retaining ferromagnetic particles within the boundaries of a tumor, a device for removing contents of a tumor, and a device for transferring ferromagnetic particles towards a tumor.

摘要翻译： 提供了一种方法，其中将含有铁磁颗粒的悬浮液引入体内，并使颗粒朝向肿瘤移动，并通过磁场保持在那里。 肿瘤的面积暴露于电磁场，以使肿瘤的高热度达到足以杀死癌细胞的温度。 去除肿瘤的内容物。 通过测定嗜中性粒细胞和巨噬细胞的活性，在治疗期间监测患者身体的状况。 还提供了一种用于执行该方法的装置，并且包括具有发射器，温度拾取器和连接到比较器的输入的温度设定器的电磁辐射源，温度控制单元，用于控制连接到比较器的输出端的高热温度并形成 信号馈送到辐射源的控制输入端。 该装置还设置有用于将铁磁颗粒保持在肿瘤边界内的磁性保持器，用于去除肿瘤内容物的装置，以及用于将铁磁颗粒转移到肿瘤的装置。

公开(公告)号：US5067952A

公开(公告)日：1991-11-26

申请号：US503529

申请日：1990-04-02

申请人： Vasily F. Gudov ,  Nikolai E. Yakhontov ,  Vladimir P. Kharchenko ,  Boris K. Dolotov ,  Evgeny L. Belousov ,  Valery B. Vinitsky ,  Alexandr M. Kozlov ,  Mikail G. Akhalaya ,  Alexandr D. Koveshinikov ,  Valery F. Pugachev

发明人： Vasily F. Gudov ,  Nikolai E. Yakhontov ,  Vladimir P. Kharchenko ,  Boris K. Dolotov ,  Evgeny L. Belousov ,  Valery B. Vinitsky ,  Alexandr M. Kozlov ,  Mikail G. Akhalaya ,  Alexandr D. Koveshinikov ,  Valery F. Pugachev

IPC分类号： A61F7/00 ,  A61N1/40 ,  A61N2/10

CPC分类号： A61N1/406 ,  A61F2007/009

摘要： A method is provided wherein a suspension containing ferromagnetic particles is introduced into a body, and the particles are caused to move towards a tumor and are retained there by a magnetic field. The area of the tumor is exposed to an electromagnetic field to carry out hyperpyrexia of the tumor to a temperature sufficient to kill cancer cells. The contents of the tumor are removed. The condition of a patient's body is monitored during the treatment by determining activity of neutrophils and macrophages. An apparatus is also provided for carrying out the method and comprises an electromagnetic radiation source with emitters, temperature pickups, and a temperature setter connected to inputs of a comparator, a temperature control unit for controlling hyperpyrexia temperature connected to an output of the comparator and forming a signal fed to a control input of the source of radiation. The apparatus is also provided with a magnetic retainer for retaining ferromagnetic particles within the boundaries of a tumor, aa device for removing contents of a tumor, and a device for transferring ferromagnetic particles towards a tumor.

摘要翻译： 提供了一种方法，其中将含有铁磁颗粒的悬浮液引入体内，并使颗粒朝向肿瘤移动，并通过磁场保持在那里。 肿瘤的面积暴露于电磁场，以使肿瘤的高热度达到足以杀死癌细胞的温度。 去除肿瘤的内容物。 通过测定嗜中性粒细胞和巨噬细胞的活性，在治疗期间监测患者身体的状况。 还提供了一种用于执行该方法的装置，并且包括具有发射器，温度拾取器和连接到比较器的输入的温度设定器的电磁辐射源，温度控制单元，用于控制连接到比较器的输出的高热温度并形成 信号馈送到辐射源的控制输入端。 该装置还设置有用于将铁磁颗粒保持在肿瘤边界内的磁性保持器，用于去除肿瘤内容物的装置和用于将铁磁性颗粒转移到肿瘤的装置。