公开(公告)号：US07632409B2

公开(公告)日：2009-12-15

申请号：US11551765

申请日：2006-10-23

申请人： Charles Little ,  Victor van de Pas ,  Barry Haymore

发明人： Charles Little ,  Victor van de Pas ,  Barry Haymore

IPC分类号： B01D15/08

CPC分类号： B01D15/422 ,  C08G73/0226 ,  G01N30/96

摘要： A displacement chromatography process and displacer compounds used in the process and having the general formula (I): wherein: each group R1, R2, R3, R′1, R′2, and R′3, independently may be selected from alkyl, aryl, and aralkyl, and in which a ring containing one or more quaternary nitrogen may be formed by any one or more of R1 and R2, R1 and R′1, R1 and R4, R4 and R′4, or R4 and R5; each R4, R′4, R5 and R′5 independently may be selected from alkyl, aryl, aralkyl and —(CH2)a—(CHY)b—(CH2)c—N+R1R2R3 An−, wherein R1, R2 and R3 are as defined above; each Y independently may be selected from —H, —OH, —OR6, halo, alkyl, aryl and aralkyl, wherein —R6 may be alkyl or —(CH2)a—(CHOH)b—(CH2)c—N+R1R2R3 An−, wherein R1, R2 and R3 are as defined above; each q and z independently may be any whole number from 0 to about 6, with the proviso that q+z is equal to or less than about 6; each a, b, and c independently may be any whole number from 0 to 2, with the proviso that the sum a+b+c in any fragment is at least 1; and each An− independently may be one or more organic or inorganic, monovalent or polyvalent anion as needed to obtain a neutral compound.

摘要翻译： 在该方法中使用的具有通式（I）的置换色谱法和置换剂化合物：其中：每个基团R 1，R 2，R 3，R'1，R'2和R'3独立地可选自烷基， 芳基和芳烷基，其中含有一个或多个季氮的环可以由R 1和R 2，R 1和R'1，R 1和R 4，R 4和R'4或R 4和R 5中的任何一个或多个形成。 每个R 4，R'4，R 5和R 5独立地可以选自烷基，芳基，芳烷基和 - （CH 2）a - （CHY）b - （CH 2）c -N + R 1 R 2 R 3 An-，其中R 1， R3如上所定义; 每个Y独立地可以选自-H，-OH，-OR6，卤素，烷基，芳基和芳烷基，其中-R6可以是烷基或 - （CH2）a-（CHOH）b-（CH2）c-N + R1R2R3 An-，其中R1，R2和R3如上定义; 每个q和z独立地可以是0至约6的任何整数，条件是q + z等于或小于约6; 每个a，b和c独立地可以是0至2的任何整数，条件是任何片段中的和a + b + c之和至少为1; 并且每个An-独立地可以是一种或多种获得中性化合物所需的有机或无机，一价或多价阴离子。

公开(公告)号：US20070102363A1

公开(公告)日：2007-05-10

申请号：US11551765

申请日：2006-10-23

申请人： Charles Little ,  Victor van de Pas ,  Barry Haymore

发明人： Charles Little ,  Victor van de Pas ,  Barry Haymore

IPC分类号： B01D15/08

CPC分类号： B01D15/422 ,  C08G73/0226 ,  G01N30/96

摘要： A displacement chromatography process and displacer compounds used in the process and having the general formula (I): wherein: each group R1, R2, R3, R′1, R′2, and R′3, independently may be selected from alkyl, aryl, and aralkyl, and in which a ring containing one or more quaternary nitrogen may be formed by any one or more of R1 and R2, R1 and R′1, R1 and R4, R4 and R′4, or R4 and R5; each R4, R′4, R5 and R′5 independently may be selected from alkyl, aryl, aralkyl and —(CH2)a—(CHY)b—(CH2)c—N+R1R2R3 An−, wherein R1, R2 and R3 are as defined above; each Y independently may be selected from —H, —OH, —OR6, halo, alkyl, aryl and aralkyl, wherein —R6 may be alkyl or —(CH2)a—(CHOH)b—(CH2)c—N+R1R2R3 An−, wherein R1, R2 and R3 are as defined above; each q and z independently may be any whole number from 0 to about 6, with the proviso that q+z is equal to or less than about 6; each a, b, and c independently may be any whole number from 0 to 2, with the proviso that the sum a+b+c in any fragment is at least 1; and each An− independently may be one or more organic or inorganic, monovalent or polyvalent anion as needed to obtain a neutral compound.

公开(公告)号：US07214806B2

公开(公告)日：2007-05-08

申请号：US10795772

申请日：2004-03-08

申请人： Weilian Lang ,  Charles Little ,  Victor van de Pas

发明人： Weilian Lang ,  Charles Little ,  Victor van de Pas

IPC分类号： C07D303/08 ,  C07C211/00

CPC分类号： C07C217/42

摘要： This invention pertains to novel multiple quaternary ammonium salts and their derivatives represented by the formula: wherein each R1, R′1, R2, R′2, R3, R′3, R4 or R5 is independently selected from the group consisting alkyl, aryl, aralkyl and —CH2—CH(OR6)—CH2N+R1R2R3; wherein one or more R6 group is selected from the group consisting of: and wherein An− is an anion. This invention also pertains to novel multiple quaternary ammonium salts and their derivatives represented by the formula: wherein each R1, R′1, R2, R′2, R3 or R′3 group is independently selected from the group consisting of alkyl, aryl, aralkyl and —CH2—CH(OR4)—CH2N+R1R2R3; wherein one or more R4 group is selected from the group consisting of: and wherein An− is an anion.

摘要翻译： 本发明涉及由下式表示的新型多元季铵盐及其衍生物：其中每个R 1，R'1，R 2， R'2，R 3，R'3，R 4或R 5 > - >独立地选自烷基，芳基，芳烷基和-CH 2 - （CH 2）2 CH 2 其中R 1，R 2，R 3，R 3，R 3，R 3，R 3， 其中一个或多个R 6基团选自：和其中An -O - 是阴离子。 本发明还涉及由下式表示的新型多元季铵盐及其衍生物：其中每个R 1，R'1，R 2， R'2，R 3或R“3个基团独立地选自烷基，芳基，芳烷基和-CH 3， CH 2（OR 4） - CH 2 N - - - - - - - - - - - - - - - - - - - - - SUB> 2 R 3; 其中一个或多个R 4基团选自：和其中An -O - 是阴离子。

公开(公告)号：US20050194113A1

公开(公告)日：2005-09-08

申请号：US10795772

申请日：2004-03-08

申请人： Weilian Lang ,  Charles Little ,  Victor van de Pas

发明人： Weilian Lang ,  Charles Little ,  Victor van de Pas

IPC分类号： C07C211/63 ,  C07C217/42 ,  C07D303/36 ,  C08B31/08 ,  C07D303/08

CPC分类号： C07C217/42

摘要： This invention pertains to novel multiple quaternary ammonium salts and their derivatives represented by the formula: wherein each R1, R′1, R2, R′2, R3, R′3, R4 or R5 is independently selected from the group consisting alkyl, aryl, aralkyl and —CH2—CH(OR6)—CH2N+R1R2R3; wherein one or more R6 group is selected from the group consisting of: and wherein An− is an anion. This invention also pertains to novel multiple quaternary ammonium salts and their derivatives represented by the formula: wherein each R1, R′1, R2, R′2, R3 or R′3 group is independently selected from the group consisting of alkyl, aryl, aralkyl and —CH2—CH(OR4)—CH2N+R1R2R3; wherein one or more R4 group is selected from the group consisting of: and wherein An− is an anion.

摘要翻译： 本发明涉及由下式表示的新型多元季铵盐及其衍生物：其中每个R 1，R'1，R 2， R'2，R 3，R'3，R 4或R 5 > - >独立地选自烷基，芳基，芳烷基和-CH 2 - （CH 2）2 CH 2 其中R 1，R 2，R 3，R 3，R 3，R 3，R 3， 其中一个或多个R 6基团选自：和其中An -O - 是阴离子。 本发明还涉及由下式表示的新型多元季铵盐及其衍生物：其中每个R 1，R'1，R 2， R'2，R 3或R“3个基团独立地选自烷基，芳基，芳烷基和-CH 3， CH 2（OR 4） - CH 2 N - - - - - - - - - - - - - - - - - - - - - SUB> 2 R 3; 其中一个或多个R 4基团选自：和其中An -O - 是阴离子。

公开(公告)号：US20100081844A1

公开(公告)日：2010-04-01

申请号：US12630985

申请日：2009-12-04

申请人： Charles Little ,  Victor van de Pas ,  Barry Haymore

发明人： Charles Little ,  Victor van de Pas ,  Barry Haymore

IPC分类号： C07C211/00

CPC分类号： B01D15/422 ,  C08G73/0226 ,  G01N30/96

摘要： A chemical compound having the general formula (I): wherein: each group R1, R2, R3, R′1, R′2, and R′3 is alkyl, aryl, or aralkyl; each R4, R′4, R5 and R′5 is alkyl, aryl, aralkyl or —(CH2)a—(CHY)b—(CH2)c—N+R1R2R3An−; each Y is —H, —OH, —OR6, halo, alkyl, aryl or aralkyl, wherein -R6 may be alkyl or —(CH2)a—(CHOH)b—(CH2)c—N+R1R2R3An−, and at least one Y is other than —OH or —OR6; each q and z is from 0 to about 6, and q+z is 1 to about 6; each a, b, and c is from 0 to 2, and a+b+c in any fragment is from 3 to 6; and each An− independently may be one or more or a mixture of organic or inorganic, monovalent or polyvalent anion as needed to obtain a neutral compound.

摘要翻译： 具有通式（I）的化合物：其中：R 1，R 2，R 3，R'1，R'2和R'3各自为烷基，芳基或芳烷基; 每个R 4，R'4，R 5和R 5是烷基，芳基，芳烷基或 - （CH 2）a - （CHY）b - （CH 2）c -N + R 1 R 2 R 3 AN-; 每个Y是-H，-OH，-OR 6，卤素，烷基，芳基或芳烷基，其中-R 6可以是烷基或 - （CH 2）a - （CHOH）b-（CH 2）c -N + R 1 R 2 R 3 A - 至少一个Y不是-OH或-OR6; 每个q和z为0至约6，q + z为1至约6; 每个a，b和c为0至2，任何片段中的a + b + c为3至6; 并且每个An-独立地可以是一种或多种或有机或无机，单价或多价阴离子的混合物，以获得中性化合物。