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    Neutral zwitterionic displacer molecules for hydrophobic displacement chromatography
    2.
    发明授权
    Neutral zwitterionic displacer molecules for hydrophobic displacement chromatography 有权
    用于疏水置换色谱的中性两性离子置换剂分子

    公开(公告)号：US09120846B2

    公开(公告)日：2015-09-01

    申请号：US14349102

    申请日：2012-10-03

    申请人： SACHEM, INC.

    发明人： Barry L. Haymore

    IPC分类号： A61K38/00 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C07K1/20 ,  B01D15/32 ,  B01D15/42

    CPC分类号： C07K1/20 ,  B01D15/325 ,  B01D15/422

    摘要： A process for separating organic compounds from a mixture by reverse-phase displacement chromatography, including providing a hydrophobic stationary phase; applying to the hydrophobic stationary phase a mixture comprising organic compounds to be separated; displacing the organic compounds from the hydrophobic stationary phase by applying thereto an aqueous composition comprising a non-surface active hydrophobic neutral zwitterionic displacer molecule and optionally an organic solvent; and collecting a plurality of fractions eluted from the hydrophobic stationary phase containing the separated organic compounds; in which the non-surface active hydrophobic neutral zwitterionic displacer molecule comprises a hydrophobic zwitterion having the general formula, as defined in the disclosure: [CM-R*—CM′].

    摘要翻译： 通过反相置换色谱从混合物中分离有机化合物的方法，包括提供疏水性固定相; 向疏水性固定相施加包含要分离的有机化合物的混合物; 通过向其施加包含非表面活性的疏水性中性两性离子置换剂分子和任选的有机溶剂的水性组合物来从疏水性固定相中移出有机化合物; 并收集从含有分离的有机化合物的疏水性固定相洗脱的多个级分; 其中非表面活性疏水性中性两性离子置换剂分子包含如本公开所定义的具有通式的疏水性两性离子：[CM-R * -CM']。

    Chromatographic separation processes and apparatus
    4.
    发明申请
    Chromatographic separation processes and apparatus 审中-公开
    色谱分离过程和装置

    公开(公告)号：US20040104156A1

    公开(公告)日：2004-06-03

    申请号：US10721131

    申请日：2003-11-25

    发明人： Henry S. Kolesinski ,  Jonathan N. Kremsky

    IPC分类号： C02F001/28 ,  B01D015/08

    CPC分类号： B01D15/1871 ,  B01D15/325 ,  B01D15/327 ,  B01D15/361 ,  B01D15/3804 ,  B01D15/422 ,  G01N30/461 ,  G01N30/466 ,  G01N30/468 ,  G01N30/606 ,  G01N30/6069 ,  G01N30/90 ,  G01N2030/8881

    摘要： There are described processes and apparatus for the separation of components from a mixture of components in a fluid such as biological materials in a fermentation broth or other biomass product. The fluid mixture is passed through a plurality of individual separation modules which are in sequential fluid communication, at least one of which can be isolated from the other(s). The individual separation modules include chemically active capture materials which are capable of capturing desired components from the mixture. The chemically active capture material of each individual separation module may have the same chemical activity or the chemically active capture material of at least one separation module may have a different chemical activity than that of the capture material of the other separation module(s).

    摘要翻译： 描述了用于在诸如发酵液或其他生物质产物中的生物材料的流体中从组分的混合物分离组分的方法和装置。 流体混合物通过多个单独的分离模块，这些单独的分离模块处于顺序流体连通状态，其中至少一个分离模块可以与其它分离模块隔离。 各个分离模块包括能够从混合物中捕获所需组分的化学活性捕获材料。 每个单独分离模块的化学活性捕获材料可以具有相同的化学活性，或者至少一个分离模块的化学活性捕获材料可能具有与其它分离模块的捕获材料不同的化学活性。

    Process for obtaining HMG-CoA reductase inhibitors of high purity
    5.
    发明授权
    Process for obtaining HMG-CoA reductase inhibitors of high purity 失效
    获得高纯度HMG-CoA还原酶抑制剂的方法

    公开(公告)号：US06695969B1

    公开(公告)日：2004-02-24

    申请号：US09720952

    申请日：2001-01-03

    申请人： Rok Grahek ,  Dusan Milivojevic ,  Andrej Bastarda

    发明人： Rok Grahek ,  Dusan Milivojevic ,  Andrej Bastarda

    IPC分类号： B01D1508

    CPC分类号： B01D15/422 ,  C07C67/52 ,  C07C69/33

    摘要： Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as and antihypercholesterolemic agents. The majority of them are produced by fermentation using microorganisms of different species identified as species belonging to Aspergilus, Monascus, Nocardia, Amycolatopsis, Mucor or Penicilium genus, some are obtained by treating the fermentation products using the method of chemical synthesis or they are the products of total chemical synthesis. The purity of the active ingredient is an important factor for manufacturing the safe and effective pharmaceutical, especially if the pharmaceutical product must be taken on a longer term basis in the treatment or prevention of high plasma cholesterol. The accumulation of the impurities from the pharmaceuticals of lower purity may cause many side effects during the medical treatment. The present invention relates to a new industrial process for the isolation of HMG-CoA reductase inhibitors using so-called displacement chromatography. Use of the invention enables to obtain HMG-CoA reductase inhibitors of high purity, with high yields, lower production costs and suitable ecological balance.

    摘要翻译： 洛伐他汀，普伐他汀，辛伐他汀，美伐他汀，阿托伐他汀及其衍生物和类似物被称为HMG-CoA还原酶抑制剂，并用作和抗高胆固醇血症药。 它们中的大多数是通过使用被鉴定为曲霉属，红曲霉，诺卡氏菌属，无性系，毛霉属或青霉属的物种的不同物种的微生物进行发酵的，一些是通过使用化学合成方法处理发酵产物而得到的，或者它们是产物 的化学合成总量。 活性成分的纯度是制造安全有效的药物的重要因素，特别是如果药物产品必须长期服用于治疗或预防高血浆胆固醇。 来自低纯度药物的杂质的积累可能在治疗期间引起许多副作用。 本发明涉及使用所谓的位移色谱法分离HMG-CoA还原酶抑制剂的新工业方法。 使用本发明能够获得高纯度的HMG-CoA还原酶抑制剂，产率高，生产成本低，生态平衡适宜。

    Method for displacement chromatography
    7.
    发明授权
    Method for displacement chromatography 有权
    置换色谱法

    公开(公告)号：US06576134B1

    公开(公告)日：2003-06-10

    申请号：US09807905

    申请日：2001-04-19

    申请人： Erik Agner

    发明人： Erik Agner

    IPC分类号： B01D1508

    CPC分类号： G01N30/34 ,  G01N30/02 ,  B01D15/422

    摘要： A method of sample displacement chromatography separation which comprises applying a multicomponent sample to one end of a chromatography bed comprising stationary phase material having affinity for components of the sample, causing components of the sample to become distributed along the chromatography bed by passage over the bed of a non-eluting mobile solvent phase, and recovering a desired component of the sample from at lest a portion of the chromatography bed, in which the sample components are applied to the chromatography bed in a non-homogeneous manner such that the concentration of at least one component with relatively low affinity for the stationary phase material is enhanced during an earlier part of sample application and/or the concentration of at least one component with relatively high affinity for the stationary phase material is enhanced during a later part of sample application.

    摘要翻译： 一种样品置换色谱分离的方法，其包括将多组分样品施加到包含对样品组分具有亲和性的固定相材料的色谱床的一端，使得样品的组分通过层析床 非洗脱的流动性溶剂相，并且从至少一部分色谱层中回收样品的所需组分，其中将样品组分以非均匀的方式施用于色谱层，使得至少 在固定相材料的较早部分期间增强对固定相材料的亲和力相对较低的一种组分，和/或在样品施用的较后部分期间增强对固定相材料具有相对高亲和力的至少一种组分的浓度。

    Displacement chemical regeneration method and apparatus
    8.
    发明申请
    Displacement chemical regeneration method and apparatus 有权
    位移化学再生方法及装置

    公开(公告)号：US20020197727A1

    公开(公告)日：2002-12-26

    申请号：US10179725

    申请日：2002-06-24

    申请人： Dionex Corporation

    发明人： Kannan Srinivasan ,  Christopher A. Pohl

    IPC分类号： G01N030/02

    CPC分类号： G01N30/96 ,  G01N30/02 ,  G01N2030/965 ,  B01D15/422

    摘要： Apparatus for chromatographically separating ionic species in an aqueous electrolyte-containing eluent to form an effluent, suppressing the effluent, detecting the suppressed effluent and passing the detected effluent to a regenerant reservoir, thereby displacing the regenerant to flow to the suppressor.

    摘要翻译： 用于在含水电解质的洗脱液中色谱分离离子物质以形成流出物，抑制流出物，检测被抑制的流出物并将检测到的流出物传递到再生剂储存器的装置，从而使再生剂移动以流向抑制器。

    Displacement chemical regeneration method and apparatus
    9.
    发明授权
    Displacement chemical regeneration method and apparatus 有权
    位移化学再生方法及装置

    公开(公告)号：US06436719B1

    公开(公告)日：2002-08-20

    申请号：US09520731

    申请日：2000-03-08

    申请人： Kannan Srinivasan ,  Christopher A. Pohl

    发明人： Kannan Srinivasan ,  Christopher A. Pohl

    IPC分类号： G01N3002

    CPC分类号： G01N30/96 ,  G01N30/02 ,  G01N2030/965 ,  B01D15/422

    摘要： A method of chromatographically separating ionic species in an aqueous electrolyte-containing eluent to form an effluent, suppressing the effluent, detecting the suppressed effluent and passing the detected effluent to a regenerant reservoir, thereby displacing the regenerant to flow to the suppressor, wherein the regenerant and effluent are of different chemical compositions.

    摘要翻译： 一种在含水电解质的洗脱液中色谱分离离子物质以形成流出物，抑制流出物，检测被抑制的流出物并将检测到的流出物传递到再生剂储存器的方法，从而使再生剂流向抑制器，其中再生剂 流出物的化学成分不同。