公开(公告)号：US20240209252A1

公开(公告)日：2024-06-27

申请号：US18225485

申请日：2023-07-24

Applicant: Aziz Hikem ,  Madhukar Chetty ,  Derek Vaughn ,  Prasad Taranekar ,  Jeffery W. Balko

Inventor： Aziz Hikem ,  Madhukar Chetty ,  Derek Vaughn ,  Prasad Taranekar ,  Jeffery W. Balko

IPC: C09K8/575 ,  C07C19/01 ,  C07C22/04 ,  C07C55/02 ,  C07C55/22 ,  C07C211/09 ,  C07C211/13 ,  C07D303/08 ,  C09K8/60 ,  C09K8/86

CPC classification number: C09K8/575 ,  C07C19/01 ,  C07C22/04 ,  C07C55/02 ,  C07C55/22 ,  C07C211/09 ,  C07C211/13 ,  C07D303/08 ,  C09K8/607 ,  C09K8/86 ,  C09K2208/12

Abstract: Clay stabilization compositions include one or a plurality of triamino compounds and/or derivatives thereof, fluids containing an effective amount of the clay stabilization compositions and methods for making and using same.

公开(公告)号：US20220213048A1

公开(公告)日：2022-07-07

申请号：US17607429

申请日：2020-04-29

Applicant: Boehringer Ingelheim International GmbH

Inventor： Nitinchandra D. PATEL

IPC: C07D301/19 ,  C07D303/16 ,  C07D303/08

Abstract: The present invention relates to compound of formula (I), wherein R1 is chloro, bromo iodo or a brosylate group. The present invention also relates to methods of making this compound and its use in carrying out organic transformations.

公开(公告)号：US08981132B2

公开(公告)日：2015-03-17

申请号：US14252149

申请日：2014-04-14

Applicant: Dow Global Technologies LLC

Inventor： Hannah L. Crampton

IPC: C07D303/00 ,  C07D303/08 ,  B01J29/89 ,  B01J37/02 ,  B01J37/06 ,  B01J38/52 ,  C07D301/12

CPC classification number: C07D303/08 ,  B01J29/89 ,  B01J37/0203 ,  B01J37/0209 ,  B01J37/06 ,  B01J38/52 ,  C07D301/12 ,  Y02P20/584

Abstract: A pretreated titanium silicalite with MFI structure (TS-1) catalyst which has been pretreated with methanol, and then optionally filtered and optionally air-dried to form a pretreated activated TS-1 catalyst. The activated TS-1 may be used in an epoxidation reaction with no additional methanol added and has equivalent activity to TS-1 used with large excesses of methanol. By removing the need for additional methanol during the reaction, the losses of epichlorohydrin from solvolysis are minimized significantly.

Abstract translation: 具有MFI结构（TS-1）催化剂的预处理的钛硅沸石，其已经用甲醇预处理，然后任选地过滤并任选地空气干燥以形成预处理的活化的TS-1催化剂。 活化的TS-1可以在环氧化反应中使用，没有添加额外的甲醇，并且与使用大量过量的甲醇的TS-1具有同等的活性。 通过在反应期间除去对另外的甲醇的需要，溶剂分解的表氯醇的损失被显着地最小化。

公开(公告)号：US08969601B2

公开(公告)日：2015-03-03

申请号：US13806983

申请日：2011-06-08

Applicant: Won Seob Song ,  Sung Yul Woo ,  Boo Weon Song ,  Seong Han Park ,  Myoung Suk Kwon

Inventor： Won Seob Song ,  Sung Yul Woo ,  Boo Weon Song ,  Seong Han Park ,  Myoung Suk Kwon

IPC: C07C31/34 ,  C07D301/24 ,  C07D301/28 ,  C07C29/62 ,  C07C29/80 ,  C07D303/08

CPC classification number: C07D301/28 ,  C07C29/62 ,  C07C29/80 ,  C07D301/24 ,  C07D303/08 ,  C07C31/36 ,  C07C31/34

Abstract: Disclosed are a method for preparing chlorohydrins composition and a method for preparing epichlorohydrin using chlorohydrins prepared thereby. The disclosed method for preparing chlorohydrins composition reacts polyhydroxy aliphatic hydrocarbon with a chlorination agent in the presence of a catalyst, comprises at least one combination of a series of unit operations including a first reaction step, a water removal step, and a second reaction step in the respective order, and additionally comprises a step for reacting the chlorohydrins composition derived from a plurality of reaction mixtures discharged from the plurality of reaction steps with an alkaline chemical, and removing the catalyst included in the chlorohydrins composition in the form of an alkali metal salt. The disclosed method for preparing epichlorohydrin includes a step for contacting the chlorohydrins composition, which was prepared using the method for preparing chlorohydrins composition, with an alkaline chemical.

Abstract translation: 公开了一种制备氯代醇组合物的方法和使用由此制备的氯代醇制备表氯醇的方法。 所公开的制备氯氢化物组合物的方法在催化剂存在下使多羟基脂族烃与氯化剂反应，包括一系列单元操作的组合，包括第一反应步骤，除水步骤和第二反应步骤 各自的顺序，并且另外包括使从多个反应步骤排出的多个反应混合物中衍生的氯醇组合物与碱性化学物质反应的步骤，并且将碱金属盐形式的氯代醇组合物中所含的催化剂除去 。 所公开的制备表氯醇的方法包括使用用于制备氯醇盐组合物的方法制备的氯代醇组合物与碱性化学品接触的步骤。

公开(公告)号：US08664413B2

公开(公告)日：2014-03-04

申请号：US13636153

申请日：2011-03-02

Applicant: Michiya Ishikawa ,  Hidetoshi Kato ,  Jiro Nakatani ,  Atsuhito Arai ,  Hiroaki Sakata ,  Hiroshi Taiko

Inventor： Michiya Ishikawa ,  Hidetoshi Kato ,  Jiro Nakatani ,  Atsuhito Arai ,  Hiroaki Sakata ,  Hiroshi Taiko

IPC: C07D301/24 ,  C07D303/08

CPC classification number: C07D301/27 ,  B01J31/0239 ,  B01J31/0268 ,  B01J2231/40 ,  C07D303/36

Abstract: An epoxy compound of high-purity N,N,N′,N′-tetraglycidyl-3,4′-diaminodiphenyl ether is produced by: an addition reaction step of reacting 3,4′-diaminodiphenyl ether with epichlorohydrin in a polar protic solvent at 65 to 100° C. for 12 hours or longer to form N,N,N′,N′-tetrakis(3-chloro-2-hydroxypropyl)-3,4′-diaminodiphenyl ether; and a cyclization reaction step of reacting the N,N,N′,N′-tetrakis(3-chloro-2-hydroxypropyl)-3,4′-diaminodiphenyl ether with an alkali compound for dehydrochlorination.

Abstract translation: 通过以下步骤制备高纯度N，N，N'，N'-四缩水甘油基-3,4'-二氨基二苯醚的环氧化合物：在极性质子溶剂中使3,4'-二氨基二苯醚与表氯醇反应的加成反应步骤 在65〜100℃下反应12小时以上以形成N，N，N'，N'-四（3-氯-2-羟丙基）-3,4'-二氨基二苯醚; 和使N，N，N'，N'-四（3-氯-2-羟丙基）-3,4'-二氨基二苯醚与碱性化合物反应脱氯化氢的环化反应步骤。

公开(公告)号：US08318959B1

公开(公告)日：2012-11-27

申请号：US13343132

申请日：2012-01-04

Applicant: Kurt Baum ,  Wen-Huey Lin

Inventor： Kurt Baum ,  Wen-Huey Lin

IPC: C07D303/08 ,  C07D303/36 ,  C07D303/48

CPC classification number: C07D303/08 ,  C07D303/22

Abstract: The method of preparing novel allyl ethers.Novel glycidyl ethers and their preparation.Polyfunctional poly(glycidyl ethers) their methods of preparation.Novel polyurethanes based on the polyfunctional glycidyl ethers and their method of preparation.

Abstract translation: 制备新型烯丙基醚的方法。 新型缩水甘油醚及其制备方法。 多官能聚（缩水甘油醚）的制备方法。 基于多官能缩水甘油醚的新型聚氨酯及其制备方法。

公开(公告)号：US20110137056A1

公开(公告)日：2011-06-09

申请号：US12956133

申请日：2010-11-30

Applicant: Jean-Paul Dejonghe ,  Koen Peeters ,  Marc Renard

Inventor： Jean-Paul Dejonghe ,  Koen Peeters ,  Marc Renard

IPC: C07D303/08 ,  C07C67/343 ,  C07C231/02 ,  C07C33/46 ,  C07C233/59

CPC classification number: C07D303/08 ,  C07B2200/07 ,  C07C29/143 ,  C07C33/46 ,  C07C67/343 ,  C07C231/02 ,  C07C233/58 ,  C07C2601/02 ,  C07D301/26 ,  C07C69/753

Abstract: The present invention relates to compounds useful as pharmaceutical intermediates, to processes for preparing the intermediates, to intermediates used in the processes, and to the use of the intermediates in the preparation of pharmaceuticals. In particular, the present invention concerns enantiomerically pure trans-cyclopropane carboxylic acid derivatives, processes for preparing the carboxylic acid derivatives and their use in preparing pharmaceuticals.

Abstract translation: 本发明涉及可用作药物中间体的化合物，制备中间体的方法，用于该方法的中间体以及中间体在制备药物中的用途。 特别地，本发明涉及对映体纯的反式环丙烷羧酸衍生物，制备羧酸衍生物的方法及其在制备药物中的用途。

公开(公告)号：US20100317515A1

公开(公告)日：2010-12-16

申请号：US12808793

申请日：2008-12-12

Applicant: Jochen Dietz ,  Thomas Grote ,  Bernd Mueller ,  Jan Klaas Lohmann ,  Jens Renner ,  Sarah Ulmschneider ,  Alice Glaettli ,  Marianna Vrettou

Inventor： Jochen Dietz ,  Thomas Grote ,  Bernd Mueller ,  Jan Klaas Lohmann ,  Jens Renner ,  Sarah Ulmschneider ,  Alice Glaettli ,  Marianna Vrettou

IPC: A01C1/06 ,  C07D405/06 ,  C07F9/28 ,  A01N43/653 ,  C07D303/36 ,  C07D303/08 ,  C07D303/14 ,  A01P3/00

CPC classification number: A01N43/653 ,  C07D303/08 ,  C07D303/12 ,  C07D303/16 ,  C07D303/36 ,  C07D403/06

Abstract: The present invention relates to triazolylmethyloxiranes of the formula I in which the variables A, B and D have the meanings described in the claims and the description.

Abstract translation: 本发明涉及式I的三唑基甲氧基环烷，其中变量A，B和D具有权利要求书和说明书中描述的含义。

公开(公告)号：US07678798B2

公开(公告)日：2010-03-16

申请号：US11104041

申请日：2005-04-12

Applicant: Chu-Biao Xue ,  Ganfeng Cao ,  Taisheng Huang ,  Lihua Chen ,  Ke Zhang ,  Anlai Wang ,  David Meloni ,  Rajan Anand ,  Joseph Glenn ,  Brian W. Metcalf

Inventor： Chu-Biao Xue ,  Ganfeng Cao ,  Taisheng Huang ,  Lihua Chen ,  Ke Zhang ,  Anlai Wang ,  David Meloni ,  Rajan Anand ,  Joseph Glenn ,  Brian W. Metcalf

IPC: A61K31/497 ,  C07D247/02 ,  A61K31/496 ,  A61P29/00 ,  C07D237/28 ,  C07D487/00 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D411/04 ,  C07D413/04 ,  C07D417/04 ,  C07D419/04 ,  C07D241/04 ,  C07D277/22 ,  C07D307/78 ,  C07D303/08 ,  C07C49/297 ,  C07C33/46

CPC classification number: C07D401/14 ,  A61K31/496 ,  A61K31/502 ,  A61K31/506 ,  A61K45/06 ,  C07D401/06 ,  C07D417/14 ,  C07D471/04 ,  A61K2300/00

Abstract: The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.

Abstract translation: 本发明涉及式I化合物：其中可变取代基在本文中定义，其调节趋化因子受体如CCR5的活性或与其结合。 在一些实施方案中，本发明的化合物对CCR5是选择性的。 该化合物可用于例如治疗与趋化因子受体表达或活性相关的疾病，例如炎性疾病，免疫疾病和病毒感染。

公开(公告)号：US20080132719A1

公开(公告)日：2008-06-05

申请号：US11833263

申请日：2007-08-03

Applicant: Jean-Paul Dejonghe ,  Koen Peeters ,  Marc Renard

Inventor： Jean-Paul Dejonghe ,  Koen Peeters ,  Marc Renard

IPC: C07C69/76 ,  C07C233/58 ,  C07D303/08

CPC classification number: C07D303/08 ,  C07B2200/07 ,  C07C29/143 ,  C07C33/46 ,  C07C67/343 ,  C07C231/02 ,  C07C233/58 ,  C07C2601/02 ,  C07D301/26 ,  C07C69/753

Abstract: The present invention relates to compounds useful as pharmaceutical intermediates, to processes for preparing the intermediates, to intermediates used in the processes, and to the use of the intermediates in the preparation of pharmaceuticals. In particular, the present invention concerns enantiomerically pure trans-cyclopropane carboxylic acid derivatives, processes for preparing the carboxylic acid derivatives and their use in preparing pharmaceuticals.

Abstract translation: 本发明涉及可用作药物中间体的化合物，制备中间体的方法，用于该方法的中间体以及中间体在制备药物中的用途。 特别地，本发明涉及对映体纯的反式环丙烷羧酸衍生物，制备羧酸衍生物的方法及其在制备药物中的用途。