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公开(公告)号：US07926360B2
公开(公告)日：2011-04-19
申请号：US12573723
申请日：2009-10-05
申请人： Omer Haldun Unalmis , Espen S. Johansen , Leslie Wayne Perry , Alejandro Vera , Daniel Rodriguez , Vijay Ramakrishnan
发明人： Omer Haldun Unalmis , Espen S. Johansen , Leslie Wayne Perry , Alejandro Vera , Daniel Rodriguez , Vijay Ramakrishnan
IPC分类号： G01F1/00
摘要： Methods and apparatus enable measuring flow of a fluid within a conduit. For example, flowmeters may measure the velocity of production fluid flowing through production pipe of an oil/gas well. The flowmeters rely on detection of pressure variations generated as a result of a backward-facing step as a basis for flow measurement calculations. Pressure sensing occurs away from the step in a direction of the flow of the fluid in an enhanced turbulence region of the flowmeter where the inner diameter remains enlarged as a result of the step.
摘要翻译： 方法和装置能够测量导管内流体的流动。 例如，流量计可以测量流过油/气井的生产管道的生产流体的速度。 流量计依赖于作为流量测量计算的基础的后向步骤的结果产生的压力变化的检测。 在步进的结果是内径保持扩大的流量计的增强湍流区域中的流体的流动方向上的压力感测发生在离开台阶的位置。
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公开(公告)号：US08592149B2
公开(公告)日：2013-11-26
申请号：US12298661
申请日：2007-04-27
申请人： Vijay Ramakrishnan
发明人： Vijay Ramakrishnan
CPC分类号： G01N33/57407 , C07K16/2887 , C07K2317/732 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： Methods and materials are provided for determining the responsiveness of a subject to a therapy, such as an antibody therapy and for selecting and/or for treating a subject based on a FcγRIIA polymorphism, or a FcγRIIIA polymorphism, or both an FcγRIIA polymorphism and a FcγRIIIA polymorphism, including where the treatment is an therapy, such as rituximab. Methods and materials are also provided for designing, making, screening, testing and/or administering antibodies as well as for optimizing antibody therapies based upon a subject's FcγRIIA polymorphism, or FcγRIIIA polymorphism, or both the FcγRIIA polymorphism and the FcγRIIIA polymorphism.
摘要翻译： 提供了用于确定受试者对抗体治疗的反应性的方法和材料，以及用于基于FcγRIIA多态性或FcγRIIIA多态性或FcgammaRIIA多态性和FcγRIIIA多态性选择和/或治疗受试者 多态性，包括治疗是治疗的地方，如利妥昔单抗。 还提供了用于设计，制备，筛选，测试和/或施用抗体以及基于受试者的FcγRIIA多态性或FcgammaRIIIA多态性或者FcγRIIA多态性和FcγRIIIA多态性两者来优化抗体疗法的方法和材料。
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公开(公告)号：US20120030144A1
公开(公告)日：2012-02-02
申请号：US12742056
申请日：2008-11-07
申请人： Vijay Ramakrishnan
发明人： Vijay Ramakrishnan
IPC分类号： G06Q30/00
CPC分类号： C12Q1/6883 , A61K2039/505 , C07K16/00 , C07K16/2887 , C12Q2600/106 , C12Q2600/158 , G06Q30/0251 , G06Q50/22 , G06Q99/00 , G16H10/20 , G16H50/20 , Y02A90/22 , Y02A90/26
摘要： The present disclosure relates generally to methods for doing business by using one or more biomarkers (e.g., a subject's genetic polymorphisms) to improve the research, development, testing, commercialization and/or marketing of a drug by identifying those subjects for whom the particular drug is likely to be more effective.
摘要翻译： 本公开一般涉及通过使用一种或多种生物标志物（例如，受试者的遗传多态性）来进行商业的方法，以通过鉴定特定药物的那些受试者来改善药物的研究，开发，测试，商业化和/或营销 可能会更有效。
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公开(公告)号：US20100291549A1
公开(公告)日：2010-11-18
申请号：US12298661
申请日：2007-04-27
申请人： Vijay Ramakrishnan
发明人： Vijay Ramakrishnan
IPC分类号： C12Q1/68
CPC分类号： G01N33/57407 , C07K16/2887 , C07K2317/732 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： Methods and materials are provided for determining the responsiveness of a subject to a therapy, such as an antibody therapy and for selecting and/or for treating a subject based on a FcγRIIA polymorphism, or a FcγRIIIA polymorphism, or both an FcγRIIA polymorphism and a FcγRIIIA polymorphism, including where the treatment is an therapy, such as rituximab. Methods and materials are also provided for designing, making, screening, testing and/or administering antibodies as well as for optimizing antibody therapies based upon a subject's FcγRIIA polymorphism, or FcγRIIIA polymorphism, or both the FcγRIIA polymorphism and the FcγRIIIA polymorphism.
摘要翻译： 提供了用于确定受试者对治疗如抗体疗法的反应性的方法和材料，以及用于基于FcγRIIA多态性或FcγRIIA多态性选择和/或治疗受试者，或者FcγRIIA多态性和FcγRIIIA两者 多态性，包括治疗是治疗的地方，如利妥昔单抗。 还提供了用于设计，制备，筛选，测试和/或施用抗体以及基于受试者的FcγRIIA多态性或FcγRIIIA多态性或FcγRIIA多态性和FcγRIIIA多态性两者优化抗体疗法的方法和材料。
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公开(公告)号：US20100018325A1
公开(公告)日：2010-01-28
申请号：US12573723
申请日：2009-10-05
申请人： OMER HALDUN UNALMIS , Espen S. Johansen , Leslie Wayne Perry , Alejandro Vera , Daniel Rodriguez , Vijay Ramakrishnan
发明人： OMER HALDUN UNALMIS , Espen S. Johansen , Leslie Wayne Perry , Alejandro Vera , Daniel Rodriguez , Vijay Ramakrishnan
IPC分类号： G01F1/42
摘要： Methods and apparatus enable measuring flow of a fluid within a conduit. For example, flowmeters may measure the velocity of production fluid flowing through production pipe of an oil/gas well. The flowmeters rely on detection of pressure variations generated as a result of a backward-facing step as a basis for flow measurement calculations. Pressure sensing occurs away from the step in a direction of the flow of the fluid in an enhanced turbulence region of the flowmeter where the inner diameter remains enlarged as a result of the step.
摘要翻译： 方法和装置能够测量导管内流体的流动。 例如，流量计可以测量流过油/气井的生产管道的生产流体的速度。 流量计依赖于作为流量测量计算的基础的后向步骤的结果产生的压力变化的检测。 在步进的结果是内径保持扩大的流量计的增强湍流区域中的流体的流动方向上的压力感测远离步进。
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公开(公告)号：US07607361B2
公开(公告)日：2009-10-27
申请号：US12035578
申请日：2008-02-22
申请人： Omer Haldun Unalmis , Espen S. Johansen , Leslie Wayne Perry , Alejandro Vera , Daniel Rodriguez , Vijay Ramakrishnan
发明人： Omer Haldun Unalmis , Espen S. Johansen , Leslie Wayne Perry , Alejandro Vera , Daniel Rodriguez , Vijay Ramakrishnan
IPC分类号： G01F1/42
摘要： Methods and apparatus enable measuring flow of a fluid within a conduit. For example, flowmeters may measure the velocity of production fluid flowing through production pipe of an oil/gas well. The flowmeters rely on detection of pressure variations generated as a result of a backward-facing step as a basis for flow measurement calculations. Pressure sensing occurs away from the step in a direction of the flow of the fluid in an enhanced turbulence region of the flowmeter where the inner diameter remains enlarged as a result of the step.
摘要翻译： 方法和装置能够测量导管内流体的流动。 例如，流量计可以测量流过油/气井的生产管道的生产流体的速度。 流量计依赖于作为流量测量计算的基础的后向步骤的结果产生的压力变化的检测。 在步进的结果是内径保持扩大的流量计的增强湍流区域中的流体的流动方向上的压力感测远离步进。
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7.发明申请PenetraBodies: receptor-mediated targeted delivery of functionally-active human antibody fragments into cytosol for the treatment of chronic infections and diseases 审中-公开PenetraBodies：受体介导的将功能活性的人抗体片段靶向递送到胞质溶胶中，用于治疗慢性感染和疾病公开(公告)号：US20060147997A1
公开(公告)日：2006-07-06
申请号：US11290143
申请日：2005-11-30
申请人： Vijay Ramakrishnan
发明人： Vijay Ramakrishnan
CPC分类号： C07K16/1072 , A61K47/6839 , A61K47/6879 , C07K16/1045 , C07K2317/21 , C07K2317/622 , C07K2317/82 , C07K2319/00
摘要： The present invention relates to methods of making and using chimeric antibody molecules comprised of at least two domains, namely RAF, and IAF, linked by a flexible peptide linker.
摘要翻译： 本发明涉及制备和使用由柔性肽接头连接的由至少两个结构域组成的嵌合抗体分子的方法，所述至少两个结构域即R 1 AF 1和I 2 AF 1。
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8.发明授权Multiphase flow meter for subsea applications using hydrate inhibitor measurement 有权使用水合物抑制剂测量的海底应用的多相流量计公开(公告)号：US09002650B2
公开(公告)日：2015-04-07
申请号：US12860720
申请日：2010-08-20
IPC分类号： G01F1/74 , G01N21/35 , G01F1/44 , G01F1/88 , G01N21/359 , G01N21/3577
CPC分类号： G01N21/35 , G01F1/44 , G01F1/74 , G01F1/88 , G01N21/3577 , G01N21/359
摘要： Methods and apparatus for determining phase fractions (relative concentrations) within a multiphase fluid mixture, in the presence of an injected hydrate inhibitor. Combining this phase fraction information with a hydrate inhibitor injection rate (HIIR) enables resolving oil and water flow rates for the phase fractions. The liquid flow rates and a total combined flow rate of the fluid mixture—determined based on a differential pressure of the fluid mixture through a given area—enable resolving a gas flow rate.
摘要翻译： 在注入的水合物抑制剂存在下，确定多相流体混合物内的相分数（相对浓度）的方法和装置。 将该相分数信息与水合物抑制剂注入速率（HIIR）组合使得能够分解相分数的油和水流速。 基于流体混合物的压差确定的流体混合物的液体流速和总的组合流速，通过给定的面积来确定气体流速。
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9.发明申请MULTIPHASE FLOW METER FOR SUBSEA APPLICATIONS USING HYDRATE INHIBITOR MEASUREMENT 有权多相流量计用于使用水合物抑制剂测量的SUBSEA应用公开(公告)号：US20120046870A1
公开(公告)日：2012-02-23
申请号：US12860720
申请日：2010-08-20
CPC分类号： G01N21/35 , G01F1/44 , G01F1/74 , G01F1/88 , G01N21/3577 , G01N21/359
摘要： Methods and apparatus for determining phase fractions (relative concentrations) within a multiphase fluid mixture, in the presence of an injected hydrate inhibitor. Combining this phase fraction information with a hydrate inhibitor injection rate (HIIR) enables resolving oil and water flow rates for the phase fractions. The liquid flow rates and a total combined flow rate of the fluid mixture—determined based on a differential pressure of the fluid mixture through a given area—enable resolving a gas flow rate.
摘要翻译： 在注入的水合物抑制剂存在下，确定多相流体混合物内的相分数（相对浓度）的方法和装置。 将该相分数信息与水合物抑制剂注入速率（HIIR）组合使得能够分解相分数的油和水流速。 基于流体混合物的压差确定的流体混合物的液体流速和总的组合流速，通过给定的面积来确定气体流速。
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公开(公告)号：US20120039871A1
公开(公告)日：2012-02-16
申请号：US12742066
申请日：2008-11-07
申请人： Vijay Ramakrishnan
发明人： Vijay Ramakrishnan
IPC分类号： A61K39/395 , A61P37/06 , A61P31/00 , A61P35/00
CPC分类号： C12Q1/6883 , A61K2039/505 , C07K16/00 , C07K16/2887 , C12Q2600/106 , C12Q2600/158 , G06Q30/0251 , G06Q50/22 , G06Q99/00 , G16H10/20 , G16H50/20 , Y02A90/22 , Y02A90/26
摘要： Methods and materials are provided for selecting and/or treating a subject based on a FcγRIIA polymorphism, or a FcγRIIB polymorphism, or both an FcγRIIA polymorphism and a FcγRIIB polymorphism, for treatment with a therapy including an antibody therapy such as rituximab. Methods are also provided for designing, making, screening, testing and/or administering antibodies as well as for optimizing antibody therapies based upon a subject's FcγRIIA polymorphism, or FcγRIIB polymorphism, or both the FcγRIIA polymorphism and the FcγRIIB polymorphism.
摘要翻译： 提供了用于基于FcγRIIA多态性或FcγRIIB多态性或FcγRIIA多态性和FcγRIIB多态性选择和/或治疗受试者的方法和材料，用于包括抗体治疗如利妥昔单抗的治疗。 还提供了用于设计，制备，筛选，测试和/或施用抗体以及基于受试者的FcγRIIA多态性或FcγRIIB多态性或FcγRIIA多态性和FcγRIIB多态性两者优化抗体疗法的方法。
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