公开(公告)号：US09395286B2

公开(公告)日：2016-07-19

申请号：US13977108

申请日：2011-12-30

申请人： Michael J. Cima ,  Gregory J. Ekchian ,  Christophoros C. Vassiliou ,  Vincent H. Liu ,  Christoph Wald ,  Sebastian Flacke ,  Fredric D. Gordon

发明人： Michael J. Cima ,  Gregory J. Ekchian ,  Christophoros C. Vassiliou ,  Vincent H. Liu ,  Christoph Wald ,  Sebastian Flacke ,  Fredric D. Gordon

IPC分类号： C12M1/34 ,  C12M1/00 ,  C12Q1/70 ,  G01N33/53 ,  G01N1/34 ,  A61F2/01 ,  G01N33/543

CPC分类号： G01N1/34 ,  A61F2/01 ,  G01N33/5302 ,  G01N33/5306 ,  G01N33/54313 ,  G01N33/56983

摘要： Trapping devices and methods are provided for capturing a medical analyte, in blood or another biological fluid. The device may include a structural substrate and a binding agent, such as an antibody, affixed to the structural substrate, wherein the binding agent is capable of binding or attaching with a medical analyte, such as a viral particle, and the device is configured for placement in a biological cavity or vessel (containing a biological fluid) in a patient. The trapping device, which may be in a twisted coil shape, is configured to trap at least some of the medical analyte, such a viral particle, present in the biological fluid. The method may include deploying a trapping device into the patient's blood vessel; after a period following the deployment, removing the trapping device from the biological cavity or blood vessel; and then analyzing the trapping device for the presence of the medical analyte.

摘要翻译： 提供捕获装置和方法用于捕获血液或其它生物流体中的医学分析物。 该装置可以包括结构底物和粘附到结构底物上的结合剂，例如抗体，其中结合剂能够与医学分析物例如病毒颗粒结合或附着，并且该装置被配置用于 放置在患者体内的生物腔或血管（含有生物流体）中。 可以处于扭曲线圈形状的捕获装置构造成捕获存在于生物流体中的至少一些医学分析物（例如病毒颗粒）。 该方法可以包括将捕获装置部署到患者的血管中; 在部署之后一段时间后，将捕获装置从生物腔或血管中取出; 然后分析捕获装置是否存在医用分析物。

公开(公告)号：US20140004503A1

公开(公告)日：2014-01-02

申请号：US13977108

申请日：2011-12-30

申请人： Michael J. Cima ,  Gregory J. Ekchian ,  Christophoros C. Vassiliou ,  Vincent H. Liu ,  Christoph Wald ,  Sebastian Flacke ,  Fredric D. Gordon

发明人： Michael J. Cima ,  Gregory J. Ekchian ,  Christophoros C. Vassiliou ,  Vincent H. Liu ,  Christoph Wald ,  Sebastian Flacke ,  Fredric D. Gordon

IPC分类号： G01N1/34

CPC分类号： G01N1/34 ,  A61F2/01 ,  G01N33/5302 ,  G01N33/5306 ,  G01N33/54313 ,  G01N33/56983

摘要： Trapping devices and methods are provided for capturing a medical analyte, in blood or another biological fluid. The device may include a structural substrate and a binding agent, such as an antibody, affixed to the structural substrate, wherein the binding agent is capable of binding or attaching with a medical analyte, such as a viral particle, and the device is configured for placement in a biological cavity or vessel (containing a biological fluid) in a patient. The trapping device, which may be in a twisted coil shape, is configured to trap at least some of the medical analyte, such a viral particle, present in the biological fluid. The method may include deploying a trapping device into the patient's blood vessel; after a period following the deployment, removing the trapping device from the biological cavity or blood vessel; and then analyzing the trapping device for the presence of the medical analyte.

摘要翻译： 提供捕获装置和方法用于捕获血液或其它生物流体中的医学分析物。 该装置可以包括结构底物和粘附到结构底物上的结合剂，例如抗体，其中结合剂能够与医学分析物例如病毒颗粒结合或附着，并且该装置被配置用于 放置在患者体内的生物腔或血管（含有生物流体）中。 可以处于扭曲线圈形状的捕获装置构造成捕获存在于生物流体中的至少一些医学分析物（例如病毒颗粒）。 该方法可以包括将捕获装置部署到患者的血管中; 在部署之后一段时间后，将捕获装置从生物腔或血管中取出; 然后分析捕获装置以获得医用分析物的存在。