公开(公告)号：US20080057082A1

公开(公告)日：2008-03-06

申请号：US11875286

申请日：2007-10-19

Applicant: Brigitte COLAU ,  Francoise Denamur ,  Isabelle Knott ,  Annick Poliszczak ,  Georges Thiry ,  Vincent Velde

Inventor： Brigitte COLAU ,  Francoise Denamur ,  Isabelle Knott ,  Annick Poliszczak ,  Georges Thiry ,  Vincent Velde

IPC: A61K39/15 ,  A61P31/12

CPC classification number: A61K39/15 ,  A61K8/0216 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/19 ,  A61K9/2095 ,  A61K39/12 ,  A61K39/39 ,  A61K47/02 ,  A61K47/183 ,  A61K47/26 ,  A61K47/36 ,  A61K2039/5254 ,  A61K2039/542 ,  A61K2039/55505 ,  C07K14/005 ,  C12N7/00 ,  C12N2720/12321 ,  C12N2720/12322 ,  C12N2720/12332 ,  C12N2720/12334 ,  C12N2720/12351 ,  Y02A50/466

Abstract: The invention provides an attenuated rotavirus population comprising a single variant or substantially a single variant which is defined by a nucleotide sequence encoding at least one of the major viral proteins designated as VP4 and VP7. The invention particularly provides a rotavirus population designated as P43. The invention further provides a novel formulation for a rotavirus vaccine which is in the form of a quick dissolving tablet for immediate dissolution when placed on the tongue.