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    Stable, dried rotavirus vaccine, compositions and process for preparation thereof
    2.
    发明授权
    Stable, dried rotavirus vaccine, compositions and process for preparation thereof 有权
    稳定的干轮状病毒疫苗，组合物及其制备方法

    公开(公告)号：US08795686B2

    公开(公告)日：2014-08-05

    申请号：US13056557

    申请日：2009-11-06

    Applicant: Rajeev M. Dhere ,  Sambhaji S. Pisal ,  Jagdish K. Zade

    Inventor： Rajeev M. Dhere ,  Sambhaji S. Pisal ,  Jagdish K. Zade

    IPC: A61K39/15

    CPC classification number: A61K39/15 ,  A61K39/12 ,  A61K2039/5252 ,  C12N7/00 ,  C12N2720/12334 ,  C12N2720/12351

    Abstract: The present invention provides novel lyophilized rotavirus vaccine formulations and methods of their preparation. The formulations include vaccine stabilizers, resulting in a vaccine formulation with enhanced stability and minimal loss of potency. The rotavirus vaccine formulations comprise an advantageous ratio of a disaccharide (such as sucrose) to an amino acid (such as glycine). The lyophilization results in a virus formulation with 100% virus preservation and residual moisture from about 0.8% to 1.4%.

    Abstract translation: 本发明提供新的冻干轮状病毒疫苗制剂及其制备方法。 制剂包括疫苗稳定剂，产生具有增强的稳定性和最小的效力损失的疫苗制剂。 轮状病毒疫苗制剂包含二糖（例如蔗糖）与氨基酸（例如甘氨酸）的有利比例。 冷冻干燥导致具有100％病毒保存和残留水分的病毒制剂从约0.8％至1.4％。

    Production of vaccines
    7.
    发明授权
    Production of vaccines 有权
    生产疫苗

    公开(公告)号：US07964198B2

    公开(公告)日：2011-06-21

    申请号：US12380095

    申请日：2009-02-24

    Applicant: Maria G. Pau ,  Alphonsus G. C. M. UytdeHaag ,  Govert J. Schouten

    Inventor： Maria G. Pau ,  Alphonsus G. C. M. UytdeHaag ,  Govert J. Schouten

    IPC: A61K39/145

    CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/70 ,  C12N7/00 ,  C12N2720/12351 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16234 ,  C12N2770/20051 ,  C12N2770/24051 ,  C12N2770/24151

    Abstract: Means and methods for producing mammalian viruses, the method comprising infecting a culture of immortalized human cells with a virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium, and removing the virus-containing medium. The viruses can be harvested and be used for the production of vaccines. Advantages include that human cells of the present invention can be cultured under defined serum-free conditions and the cells show improved capability for propagating virus. Methods are provided for producing, in cultured human cells, influenza virus and vaccines derived thereof. This method eliminates the necessity of using whole chicken embryos for the production of Influenza vaccines. The method also provides for the continuous or batch-wise removal of culture media. As such, the present invention allows the large-scale continuous production of viruses to a high titer.

    Abstract translation: 用于生产哺乳动物病毒的方法和方法，所述方法包括用病毒感染永生化人细胞的培养物，在病毒生长的条件下孵育感染病毒的培养物繁殖病毒，并形成含病毒的培养基， 并除去含病毒的培养基。 可以收获病毒并用于生产疫苗。 优点包括本发明的人细胞可以在规定的无血清条件下进行培养，并且细胞显示出增强的病毒传播能力。 提供了用于在培养的人类细胞中产生流感病毒及其衍生的疫苗的方法。 该方法消除了使用全鸡胚胎生产流感疫苗的必要性。 该方法还提供了连续或间歇地除去培养基。 因此，本发明允许病毒的大规模连续生产达到高滴度。

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