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1.发明授权公开(公告)号：US07563912B2
公开(公告)日：2009-07-21
申请号：US11488073
申请日：2006-07-18
Applicant: Celal Ates , John Surtees , Anne-Catherine Burteau , Violeta Marmon , Emile Cavoy
Inventor： Celal Ates , John Surtees , Anne-Catherine Burteau , Violeta Marmon , Emile Cavoy
IPC: C07D207/12 , C07D207/24 , C07D207/36
CPC classification number: C07D207/27 , C07D207/26
Abstract: The present invention relates to an improved process for the preparation of (S)-(−)-α-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof. The invention also relates to compounds of the general formula (6) wherein R1 is methyl or ethyl; and R2 is C?2#191 -C?4#191 alkyl, C?2#191-C?4#191 alkenyl or C?2#191-C?4#191 alkynyl, optionally substituted by one or more halogen, and their preparation processes.
Abstract translation: 本发明涉及制备（S） - （ - ） - α-乙基-2-氧代-1-吡咯烷乙酰胺及其类似物的改进方法。 本发明还涉及通式（6）的化合物，其中R 1是甲基或乙基; R 2为C 2〜C 19 -C 191烷基，C 2〜19 C 191〜C 4〜C 19烷基或C 2〜19 C 191 -C 4 4 191烷基，任选被一个或多个卤素， 及其制备过程。
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公开(公告)号：US20050159475A1
公开(公告)日：2005-07-21
申请号：US11028039
申请日：2005-01-04
Applicant: John Surtees , Violeta Marmon , Edmond Differding , Vincent Zimmermann
Inventor： John Surtees , Violeta Marmon , Edmond Differding , Vincent Zimmermann
IPC: C07D401/04 , A61K31/4015 , A61K31/4025 , A61K31/41 , A61K31/4178 , A61K31/4188 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/541 , A61P9/00 , A61P9/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/16 , A61P37/08 , C07B61/00 , C07C237/06 , C07C237/12 , C07D207/26 , C07D207/27 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04 , C07D207/12 , C07D43/02
CPC classification number: C07D207/26 , A61K31/4015 , C07C237/12 , C07D207/27 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/12 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04
Abstract: The invention concerns 2-oxo-1-pyrrolidine derivatives and a process for preparing them and their uses. The invention also concerns a process for preparing α-ethyl-2-oxo-1-pyrrolidine acetamide derivatives from unsaturated 2-oxo-1-pyrrolidine derivatives. Particularly the invention concerns novel intermediates and their use in methods for the preparation of S-α-ethyl-2-oxo-1-pyrrolidine acetamide.
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公开(公告)号：US06713635B2
公开(公告)日：2004-03-30
申请号：US10204275
申请日：2002-08-20
Applicant: John Surtees , Violeta Marmon , Edmond Differding , Vincent Zimmermann
Inventor： John Surtees , Violeta Marmon , Edmond Differding , Vincent Zimmermann
IPC: C07D20704
CPC classification number: C07D207/26 , A61K31/4015 , C07C237/12 , C07D207/27 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/12 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04
Abstract: The invention concerns 2-oxo-1-pyrrolidine derivatives and a process for preparing them and their uses. The invention also concerns a process for preparing &agr;-ethyl-2-oxo-1-pyrrolidine acetamide derivatives from unsaturated 2-oxo-1-pyrrolidine derivatives. Particularly the invention concerns novel intermediates and their use in methods for the preparation of S-&agr;-ethyl-2-oxo-1-pyrrolidine acetamide.
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4.发明授权2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses 失效2-氧代-1-吡咯烷衍生物，其制备方法及其用途公开(公告)号：US07217826B2
公开(公告)日：2007-05-15
申请号：US11028039
申请日：2005-01-04
Applicant: John Surtees , Violeta Marmon , Edmond Differding , Vincent Zimmermann
Inventor： John Surtees , Violeta Marmon , Edmond Differding , Vincent Zimmermann
IPC: C07D207/04
CPC classification number: C07D207/26 , A61K31/4015 , C07C237/12 , C07D207/27 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/12 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04
Abstract: The invention concerns 2-oxo-1-pyrrolidine derivatives and a process for preparing them and their uses. The invention also concerns a process for preparing α-ethyl-2-oxo-1-pyrrolidine acetamide derivatives from unsaturated 2-oxo-1-pyrrolidine derivatives. Particularly the invention concerns novel intermediates and their use in methods for the preparation of S-α-ethyl-2-oxo-1-pyrrolidine acetamide.
Abstract translation: 本发明涉及2-氧代-1-吡咯烷衍生物及其制备方法及其应用。 本发明还涉及从不饱和2-氧代-1-吡咯烷衍生物制备α-乙基-2-氧代-1-吡咯烷乙酰胺衍生物的方法。 特别地，本发明涉及新型中间体及其在制备S-α-乙基-2-氧代-1-吡咯烷乙酰胺的方法中的用途。
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Patent Agency Ranking
5.发明申请公开(公告)号：US20060258734A1
公开(公告)日：2006-11-16
申请号：US11488073
申请日：2006-07-18
Applicant: Celal Ates , John Surtees , Anne-Catherine Burteau , Violeta Marmon , Emile Cavoy
Inventor： Celal Ates , John Surtees , Anne-Catherine Burteau , Violeta Marmon , Emile Cavoy
IPC: A61K31/4015
CPC classification number: C07D207/27 , C07D207/26
Abstract: The present invention relates to an improved process for the preparation of (S)-(−)-α-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof. The invention also relates to compounds of the general formula (6) wherein R1 is methyl or ethyl; and R2 is C?2#191 -C?4#191 alkyl, C?2#191-C?4#191 alkenyl or C?2#191-C?4#191 alkynyl, optionally substituted by one or more halogen, and their preparation processes.
Abstract translation: 本发明涉及制备（S） - （ - ） - α-乙基-2-氧代-1-吡咯烷乙酰胺及其类似物的改进方法。 本发明还涉及通式（6）的化合物，其中R 1是甲基或乙基; R 2是C 2〜19 C 19〜C 19烷基，C 2〜19 C 191〜C 4〜C 19烷基或C 2〜 任选被一个或多个卤素取代，及其制备方法。
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6.发明授权公开(公告)号：US07122682B2
公开(公告)日：2006-10-17
申请号：US10486342
申请日：2002-08-05
Applicant: Celal Ates , John Surtees , Anne-Catherine Burteau , Violeta Marmon , Emile Cavoy
Inventor： Celal Ates , John Surtees , Anne-Catherine Burteau , Violeta Marmon , Emile Cavoy
IPC: C07D207/12 , C07D207/24 , C07D207/36
CPC classification number: C07D207/27 , C07D207/26
Abstract: The present invention relates to an improved process for the preparation of (S)-(−)-α-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof. The invention also relates to compounds of the general formula (6) wherein R1 is methyl or ethyl; and R2 is C?2#191–C?4#191 alkyl, C?2#191–C?4#191 alkenyl or C?2#191–C?4#191 alkynyl, optionally substituted by one or more halogen, and their preparation processes
Abstract translation: 本发明涉及制备（S） - （ - ） - α-乙基-2-氧代-1-吡咯烷乙酰胺及其类似物的改进方法。 本发明还涉及通式（6）的化合物，其中R 1是甲基或乙基; R 2为C 2〜C 19 -C 19烷基，C 2〜19 C 191〜C 4〜C 19烷基或C 2〜19 C 191〜C 4〜 任选被一个或多个卤素取代，及其制备方法
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公开(公告)号：US06858740B2
公开(公告)日：2005-02-22
申请号：US10609544
申请日：2003-07-01
Applicant: John Surtees , Violeta Marmon , Edmond Differding , Vincent Zimmermann
Inventor： John Surtees , Violeta Marmon , Edmond Differding , Vincent Zimmermann
IPC: C07D401/04 , A61K31/4015 , A61K31/4025 , A61K31/41 , A61K31/4178 , A61K31/4188 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/541 , A61P9/00 , A61P9/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/16 , A61P37/08 , C07B61/00 , C07C237/06 , C07C237/12 , C07D207/26 , C07D207/27 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04 , C07D207/04
CPC classification number: C07D207/26 , A61K31/4015 , C07C237/12 , C07D207/27 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/12 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04
Abstract: The invention concerns 2-oxo-1-pyrrolidine derivatives and a process for preparing them and their uses. The invention also concerns a process for preparing α-ethyl-2-oxo-1-pyrrolidine acetamide derivatives from unsaturated 2-oxo-1-pyrrolidine derivatives. Particularly the invention concerns novel intermediates and their use in methods for the preparation of S-α-ethyl-2-oxo-1-pyrrolidine acetamide.
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8.发明申请Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues 审中-公开所述化合物的制备及其在制备左乙拉西坦和类似物中的用途公开(公告)号：US20070142647A1
公开(公告)日：2007-06-21
申请号：US11540519
申请日：2006-10-02
Applicant: Celal Ates , John Surtees , Anne-Catherine Burteau , Violeta Marmon , Emile Cavoy
Inventor： Celal Ates , John Surtees , Anne-Catherine Burteau , Violeta Marmon , Emile Cavoy
IPC: C07D207/267
CPC classification number: C07D207/27 , C07D207/26
Abstract: The present invention relates to an improved process for the preparation of (S)-(-)-α-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof. The invention also relates to compounds of the general formula (6) wherein R1 is methyl or ethyl; and R2 is C2-C4 alkyl, C2-C4 alkenyl or C2-C4 alkynyl, optionally substituted by one or more halogen, and their preparation processes.
Abstract translation: 本发明涉及制备（S） - （ - ） - α-乙基-2-氧代-1-吡咯烷乙酰胺及其类似物的改进方法。 本发明还涉及通式（6）的化合物，其中R 1是甲基或乙基; R 2是C 2 -C 4烷基，C 2 -C 4烷基，C 2 -C 4烷基，C 2 -C 4烷基，C 2 -C 4烷基， >链烯基或C 2 -C 4 - 炔基，其任选被一个或多个卤素取代，及其制备方法。
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9.发明授权2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses 失效2-氧代-1-吡咯烷衍生物，其制备方法及其用途公开(公告)号：US06969770B2
公开(公告)日：2005-11-29
申请号：US10824345
申请日：2004-04-15
Applicant: John Surtees , Violeta Marmon , Edmond Differding , Vincent Zimmermann
Inventor： John Surtees , Violeta Marmon , Edmond Differding , Vincent Zimmermann
IPC: C07D401/04 , A61K31/4015 , A61K31/4025 , A61K31/41 , A61K31/4178 , A61K31/4188 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/541 , A61P9/00 , A61P9/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/16 , A61P37/08 , C07B61/00 , C07C237/06 , C07C237/12 , C07D207/26 , C07D207/27 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04 , C07D207/04
CPC classification number: C07D207/26 , A61K31/4015 , C07C237/12 , C07D207/27 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/12 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04
Abstract: The invention concerns 2-oxo-1-pyrrolidine derivatives and a process for preparing them and their uses. The invention also concerns a process for preparing α-ethyl-2-oxo-1-pyrrolidine acetamide derivatives from unsaturated 2-oxo-1-pyrrolidine derivatives. Particularly the invention concerns novel intermediates and their use in methods for the preparation of S-α-ethyl-2-oxo-1-pyrrolidine acetamide.
Abstract translation: 本发明涉及2-氧代-1-吡咯烷衍生物及其制备方法及其应用。 本发明还涉及从不饱和2-氧代-1-吡咯烷衍生物制备α-乙基-2-氧代-1-吡咯烷乙酰胺衍生物的方法。 特别地，本发明涉及新型中间体及其在制备S-α-乙基-2-氧代-1-吡咯烷乙酰胺的方法中的用途。
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