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1.
公开(公告)号:US20110136133A1
公开(公告)日:2011-06-09
申请号:US12948012
申请日:2010-11-17
申请人: Virender BHAN , John Gillard , Andrea Hebb , Martin Holcik , Robert G. Korneluk , George Robertson
发明人: Virender BHAN , John Gillard , Andrea Hebb , Martin Holcik , Robert G. Korneluk , George Robertson
IPC分类号: G01N33/53
CPC分类号: C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N33/564 , G01N2800/285
摘要: Disclosed herein is a method for differentiating between multiple sclerosis subtypes in a patient. The method comprises a) determining an amount of an IAP gene expression level in a blood sample obtained from the patient; and b) correlating the amount of the IAP gene expression level in the blood sample with the presence of a multiple sclerosis subtype in the patient.
摘要翻译: 本文公开了一种用于区分患者中多发性硬化症亚型的方法。 该方法包括:a)确定从患者获得的血液样品中IAP基因表达水平的量; 和b)将血液样品中的IAP基因表达水平的量与患有多发性硬化症亚型的存在相关联。
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公开(公告)号:US07858309B2
公开(公告)日:2010-12-28
申请号:US11702657
申请日:2007-02-06
申请人: Virender Bhan , John W. Gillard , Andrea Hebb , Martin Holcik , Robert G. Korneluk , George Robertson
发明人: Virender Bhan , John W. Gillard , Andrea Hebb , Martin Holcik , Robert G. Korneluk , George Robertson
CPC分类号: C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N33/564 , G01N2800/285
摘要: Disclosed herein is a method for differentiating between multiple sclerosis subtypes in a patient. The method comprises a) determining an amount of an IAP gene expression level in a blood sample obtained from the patient; and b) correlating the amount of the IAP gene expression level in the blood sample with the presence of a multiple sclerosis subtype in the patient.
摘要翻译: 本文公开了一种用于区分患者中多发性硬化症亚型的方法。 该方法包括:a)确定从患者获得的血液样品中IAP基因表达水平的量; 和b)将血液样品中的IAP基因表达水平的量与患有多发性硬化症亚型的存在相关联。
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3.
公开(公告)号:US08021840B2
公开(公告)日:2011-09-20
申请号:US11713733
申请日:2007-03-05
申请人: Virender Bhan , Andrea Hebb , Martin Holcik , Robert G. Korneluk , Craig Moore , George Robertson
发明人: Virender Bhan , Andrea Hebb , Martin Holcik , Robert G. Korneluk , Craig Moore , George Robertson
CPC分类号: G01N33/564 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/5091 , G01N2333/4704 , G01N2333/555 , G01N2800/285 , G01N2800/52
摘要: Disclosed is a method of determining interferon responsiveness in a patient suffering from multiple sclerosis. The method comprises determining an amount of a XAF-1 gene expression level in a blood sample, which is obtained from the patient undergoing interferon therapy. The amount of the XAF-1 gene expression level in the blood sample is then correlated with the responsiveness of the patient to the interferon.
摘要翻译: 公开了一种确定患有多发性硬化症的患者的干扰素反应性的方法。 该方法包括测定从接受干扰素治疗的患者获得的血液样品中XAF-1基因表达水平的量。 然后将血样中XAF-1基因表达量的量与患者对干扰素的反应性相关。
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公开(公告)号:US20080020388A1
公开(公告)日:2008-01-24
申请号:US11702657
申请日:2007-02-06
申请人: Virender Bhan , John Gillard , Andrea Hebb , Martin Holcik , Robert Korneluk , George Robertson
发明人: Virender Bhan , John Gillard , Andrea Hebb , Martin Holcik , Robert Korneluk , George Robertson
CPC分类号: C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N33/564 , G01N2800/285
摘要: Disclosed herein is a method for differentiating between multiple sclerosis subtypes in a patient. The method comprises a) determining an amount of an IAP gene expression level in a blood sample obtained from the patient; and b) correlating the amount of the IAP gene expression level in the blood sample with the presence of a multiple sclerosis subtype in the patient.
摘要翻译: 本文公开了一种用于区分患者中多发性硬化症亚型的方法。 该方法包括:a)确定从患者获得的血液样品中IAP基因表达水平的量; 和b)将血液样品中的IAP基因表达水平的量与患有多发性硬化症亚型的存在相关联。
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5.
公开(公告)号:US20070218493A1
公开(公告)日:2007-09-20
申请号:US11713733
申请日:2007-03-05
申请人: Virender Bhan , Andrea Hebb , Martin Holcik , Robert Korneluk , Craig Moore , George Robertson
发明人: Virender Bhan , Andrea Hebb , Martin Holcik , Robert Korneluk , Craig Moore , George Robertson
CPC分类号: G01N33/564 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/5091 , G01N2333/4704 , G01N2333/555 , G01N2800/285 , G01N2800/52
摘要: Disclosed is a method of determining interferon responsiveness in a patient suffering from multiple sclerosis. The method comprises determining an amount of a XAF-1 gene expression level in a blood sample, which is obtained from the patient undergoing interferon therapy. The amount of the XAF-1 gene expression level in the blood sample is then correlated with the responsiveness of the patient to the interferon.
摘要翻译: 公开了一种确定患有多发性硬化症的患者的干扰素反应性的方法。 该方法包括测定从接受干扰素治疗的患者获得的血液样品中XAF-1基因表达水平的量。 然后将血样中XAF-1基因表达量的量与患者对干扰素的反应性相关。
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