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公开(公告)号:US07858309B2
公开(公告)日:2010-12-28
申请号:US11702657
申请日:2007-02-06
申请人: Virender Bhan , John W. Gillard , Andrea Hebb , Martin Holcik , Robert G. Korneluk , George Robertson
发明人: Virender Bhan , John W. Gillard , Andrea Hebb , Martin Holcik , Robert G. Korneluk , George Robertson
CPC分类号: C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N33/564 , G01N2800/285
摘要: Disclosed herein is a method for differentiating between multiple sclerosis subtypes in a patient. The method comprises a) determining an amount of an IAP gene expression level in a blood sample obtained from the patient; and b) correlating the amount of the IAP gene expression level in the blood sample with the presence of a multiple sclerosis subtype in the patient.
摘要翻译: 本文公开了一种用于区分患者中多发性硬化症亚型的方法。 该方法包括:a)确定从患者获得的血液样品中IAP基因表达水平的量; 和b)将血液样品中的IAP基因表达水平的量与患有多发性硬化症亚型的存在相关联。
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2.
公开(公告)号:US08021840B2
公开(公告)日:2011-09-20
申请号:US11713733
申请日:2007-03-05
申请人: Virender Bhan , Andrea Hebb , Martin Holcik , Robert G. Korneluk , Craig Moore , George Robertson
发明人: Virender Bhan , Andrea Hebb , Martin Holcik , Robert G. Korneluk , Craig Moore , George Robertson
CPC分类号: G01N33/564 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/5091 , G01N2333/4704 , G01N2333/555 , G01N2800/285 , G01N2800/52
摘要: Disclosed is a method of determining interferon responsiveness in a patient suffering from multiple sclerosis. The method comprises determining an amount of a XAF-1 gene expression level in a blood sample, which is obtained from the patient undergoing interferon therapy. The amount of the XAF-1 gene expression level in the blood sample is then correlated with the responsiveness of the patient to the interferon.
摘要翻译: 公开了一种确定患有多发性硬化症的患者的干扰素反应性的方法。 该方法包括测定从接受干扰素治疗的患者获得的血液样品中XAF-1基因表达水平的量。 然后将血样中XAF-1基因表达量的量与患者对干扰素的反应性相关。
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3.
公开(公告)号:US20110136133A1
公开(公告)日:2011-06-09
申请号:US12948012
申请日:2010-11-17
申请人: Virender BHAN , John Gillard , Andrea Hebb , Martin Holcik , Robert G. Korneluk , George Robertson
发明人: Virender BHAN , John Gillard , Andrea Hebb , Martin Holcik , Robert G. Korneluk , George Robertson
IPC分类号: G01N33/53
CPC分类号: C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N33/564 , G01N2800/285
摘要: Disclosed herein is a method for differentiating between multiple sclerosis subtypes in a patient. The method comprises a) determining an amount of an IAP gene expression level in a blood sample obtained from the patient; and b) correlating the amount of the IAP gene expression level in the blood sample with the presence of a multiple sclerosis subtype in the patient.
摘要翻译: 本文公开了一种用于区分患者中多发性硬化症亚型的方法。 该方法包括:a)确定从患者获得的血液样品中IAP基因表达水平的量; 和b)将血液样品中的IAP基因表达水平的量与患有多发性硬化症亚型的存在相关联。
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公开(公告)号:US07294713B2
公开(公告)日:2007-11-13
申请号:US10636065
申请日:2003-08-07
申请人: Robert G. Korneluk , Eric LaCasse , Stephen Baird , Martin Holcik , Sean Young
发明人: Robert G. Korneluk , Eric LaCasse , Stephen Baird , Martin Holcik , Sean Young
CPC分类号: C12N15/113 , A61K38/00 , C12N2310/12 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/3521
摘要: The present invention feature antisense IAP oligonucleotides and other negative regulators of the IAP anti-apoptotic pathway, and methods for using them to enhance apoptosis.
摘要翻译: 本发明的特征在于反义IAP寡核苷酸和IAP抗凋亡途径的其它负调节剂,以及使用它们增强细胞凋亡的方法。
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公开(公告)号:US6159709A
公开(公告)日:2000-12-12
申请号:US121979
申请日:1998-07-24
申请人: Robert G. Korneluk , Martin Holcik , Peter Liston
发明人: Robert G. Korneluk , Martin Holcik , Peter Liston
IPC分类号: C07K14/47 , C12N15/67 , C12Q1/68 , A61K48/00 , C07H21/02 , C07H21/04 , C12N15/00 , C12P21/06
CPC分类号: C12Q1/6897 , C07K14/4747 , C12N15/67
摘要: The invention features purified nucleic acid encoding a novel internal ribosome entry site (IRES) sequence from the X-linked inhibitor of apoptosis (XIAP) gene. The invention also features methods for using the XIAP IRES to increase cap-independent translation of polypeptide coding sequences linked to the XIAP IRES, and methods for isolating compounds that modulate cap-independent translation.
摘要翻译: 本发明的特征在于编码来自X连锁的凋亡抑制剂(XIAP)基因的新的内部核糖体进入位点(IRES)序列的纯化核酸。 本发明还具有使用XIAP IRES增加与XIAP IRES连接的多肽编码序列的Cap无关翻译的方法,以及用于分离调节不依赖于帽的翻译的化合物的方法。
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公开(公告)号:US06673917B1
公开(公告)日:2004-01-06
申请号:US09672717
申请日:2000-09-28
申请人: Robert G. Korneluk , Eric LaCasse , Stephen Baird , Martin Holcik , Sean Young
发明人: Robert G. Korneluk , Eric LaCasse , Stephen Baird , Martin Holcik , Sean Young
IPC分类号: C07H2104
CPC分类号: C12N15/113 , A61K38/00 , C12N2310/12 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/3521
摘要: The present invention feature antisense IAP nucleic acids and other negative regulators of the IAP anti-apoptotic pathway, and methods for using them to enhance apoptosis.
摘要翻译: 本发明的特征在于反义IAP核酸和IAP抗凋亡途径的其它负调节剂,以及使用它们增强细胞凋亡的方法。
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公开(公告)号:US06171821B2
公开(公告)日:2001-01-09
申请号:US09332319
申请日:1999-06-14
申请人: Robert G. Korneluk , Martin Holcik , Peter Liston
发明人: Robert G. Korneluk , Martin Holcik , Peter Liston
IPC分类号: C12P2106
CPC分类号: C12N15/67 , C07K14/4747 , C12Q1/6897
摘要: The invention features purified nucleic acid encoding a novel internal ribosome entry site (IRES) sequence from the X-linked inhibitor of apoptosis (XIAP) gene. The invention also features methods for using the XIAP IRES to increase cap-independent translation of polypeptide coding sequences linked to the XIAP IRES, and methods for isolating compounds that modulate cap-independent translation.
摘要翻译: 本发明的特征在于编码来自X连锁的凋亡抑制剂(XIAP)基因的新的内部核糖体进入位点(IRES)序列的纯化核酸。 本发明还具有使用XIAP IRES增加与XIAP IRES连接的多肽编码序列的Cap无关翻译的方法,以及用于分离调节不依赖于帽的翻译的化合物的方法。
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公开(公告)号:US07235372B2
公开(公告)日:2007-06-26
申请号:US11329884
申请日:2006-01-10
CPC分类号: C07K14/47 , A01K2217/05 , A01K2227/105 , A61K38/00 , A61K48/00 , C07K14/4747 , C07K16/18 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57484 , G01N2510/00
摘要: The invention provides a novel NAIP nucleic and sequences. Also provided are anti-NAIP antibodies and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
摘要翻译: 本发明提供了一种新的NAIP核酸和序列。 还提供了抗NAIP抗体和调节细胞凋亡和检测调节细胞凋亡的化合物的方法。
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公开(公告)号:US06994957B2
公开(公告)日:2006-02-07
申请号:US08913322
申请日:1997-01-17
CPC分类号: C07K14/47 , A01K2217/05 , A01K2227/105 , A61K38/00 , A61K48/00 , C07K14/4747 , C07K16/18 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57484 , G01N2510/00
摘要: The invention provides NAIP nucleic acid and sequences. Also provided are anti-NAIP antibodies and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
摘要翻译: 本发明提供NAIP核酸和序列。 还提供了抗NAIP抗体和调节细胞凋亡和检测调节细胞凋亡的化合物的方法。
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10.
公开(公告)号:US07776552B2
公开(公告)日:2010-08-17
申请号:US11498244
申请日:2006-08-03
CPC分类号: C07K14/4747 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C12Q1/6883 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/57407 , G01N33/57419 , G01N33/57423 , G01N33/57426 , G01N33/5743 , G01N33/68 , G01N33/6872 , G01N2500/00 , G01N2510/00
摘要: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primer and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
摘要翻译: 公开了基本上纯的编码哺乳动物IAP多肽的DNA; 以及使用这些DNA在细胞和动物中表达IAP多肽以抑制细胞凋亡的方法。 还公开了IAP家族特征的保守区域以及用于鉴定和分离另外的IAP基因的引物和探针。 此外,提供了治疗涉及细胞凋亡的疾病和病症的方法。
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