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    Methods and compositions for inducing apoptosis
    1.
    发明申请
    Methods and compositions for inducing apoptosis 失效
    诱导凋亡的方法和组合物

    公开(公告)号：US20090123463A1

    公开(公告)日：2009-05-14

    申请号：US10579529

    申请日：2004-11-17

    申请人： William G. Cance ,  Vita Golubovskaya

    发明人： William G. Cance ,  Vita Golubovskaya

    IPC分类号： A61K39/395 ,  C07K7/08 ,  C12N5/06 ,  A61K38/16 ,  A61P35/00 ,  C12N15/64 ,  A61K38/10

    CPC分类号： C07K14/475 ,  A61K38/00

    摘要： The C-terminal domain of focal adhesion kinase (FAK-CD) was isolated using a Baculoviral system. Using phage display techniques, a phage encoding a 12 amino-acid peptide (peptide 35) and AV3 that binds to FAK-CD were identified. The peptides were also conjugated to TAT-FITC to produce a fluorescently labeled chimeric molecule capable of penetrating cell membranes. Contacting various breast cancer cell lines with these molecule caused detachment, rounding, apoptosis and cell death. These effects were not observed in normal (non-cancerous) breast cells.

    摘要翻译： 使用杆状病毒系统分离局灶粘连激酶（FAK-CD）的C-末端结构域。 使用噬菌体展示技术，鉴定了编码结合FAK-CD的12个氨基酸肽（肽35）和AV3的噬菌体。 肽也与TAT-FITC偶联以产生能够穿透细胞膜的荧光标记的嵌合分子。 与这些分子接触各种乳腺癌细胞系导致分离，四舍五入，细胞凋亡和细胞死亡。 在正常（非癌）乳腺细胞中没有观察到这些作用。

    Methods and compositions for inducing apoptosis
    4.
    发明授权
    Methods and compositions for inducing apoptosis 失效
    诱导凋亡的方法和组合物

    公开(公告)号：US08003613B2

    公开(公告)日：2011-08-23

    申请号：US10579529

    申请日：2004-11-17

    申请人： William G. Cance ,  Vita Golubovskaya ,  Elena V. Kurenova

    发明人： William G. Cance ,  Vita Golubovskaya ,  Elena V. Kurenova

    IPC分类号： A61K38/10 ,  A61K38/04 ,  A61K39/385 ,  C07K7/08 ,  C07K16/46 ,  C07K14/71

    CPC分类号： C07K14/475 ,  A61K38/00

    摘要： The C-terminal domain of focal adhesion kinase (FAK-CD) was isolated using a Baculoviral system. Using phage display techniques, a phage encoding a 12 amino-acid peptide (peptide 35) and AV3 that binds to FAK-CD were identified. The peptides were also conjugated to TAT-FITC to produce a fluorescently labeled chimeric molecule capable of penetrating cell membranes. Contacting various breast cancer cell lines with these molecule caused detachment, rounding, apoptosis and cell death. These effects were not observed in normal (non-cancerous) breast cells.

    摘要翻译： 使用杆状病毒系统分离局灶粘连激酶（FAK-CD）的C-末端结构域。 使用噬菌体展示技术，鉴定了编码结合FAK-CD的12个氨基酸肽（肽35）和AV3的噬菌体。 肽也与TAT-FITC偶联以产生能够穿透细胞膜的荧光标记的嵌合分子。 与这些分子接触各种乳腺癌细胞系导致分离，四舍五入，细胞凋亡和细胞死亡。 在正常（非癌）乳腺细胞中没有观察到这些作用。

    METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS
    7.
    发明申请
    METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS 审中-公开
    诱发病毒的方法和组合物

    公开(公告)号：US20120164141A1

    公开(公告)日：2012-06-28

    申请号：US13214916

    申请日：2011-08-22

    申请人： William G. Cance ,  Vita Golubovskaya ,  Elena V. Kurenova

    发明人： William G. Cance ,  Vita Golubovskaya ,  Elena V. Kurenova

    IPC分类号： A61K38/10 ,  C12N5/02 ,  C12N15/63 ,  A61P35/00 ,  A61K39/395

    CPC分类号： C07K14/475 ,  A61K38/00

    摘要： The C-terminal domain of focal adhesion kinase (FAK-CD) was isolated using a Baculoviral system. Using phage display techniques, a phage encoding a 12 amino-acid peptide (peptide 35) and AV3 that binds to FAK-CD were identified. The peptides were also conjugated to TAT-FITC to produce a fluorescently labeled chimeric molecule capable of penetrating cell membranes. Contacting various breast cancer cell lines with these molecule caused detachment, rounding, apoptosis and cell death. These effects were not observed in normal (non-cancerous) breast cells.

    摘要翻译： 使用杆状病毒系统分离局灶粘连激酶（FAK-CD）的C-末端结构域。 使用噬菌体展示技术，鉴定了编码结合FAK-CD的12个氨基酸肽（肽35）和AV3的噬菌体。 肽也与TAT-FITC偶联以产生能够穿透细胞膜的荧光标记的嵌合分子。 与这些分子接触各种乳腺癌细胞系导致分离，四舍五入，细胞凋亡和细胞死亡。 在正常（非癌）乳腺细胞中没有观察到这些作用。