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1.发明授权公开(公告)号：US09663470B2
公开(公告)日：2017-05-30
申请号：US15079544
申请日：2016-03-24
IPC分类号： C07D221/06 , C07D221/10 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/06 , C07D471/04 , C07D498/04 , C07D221/16 , C07D401/04 , C07D405/04
CPC分类号： C07D221/10 , C07D221/06 , C07D221/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D417/06 , C07D471/04 , C07D498/04
摘要： The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
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2.发明申请ARYL- AND HETEROARYLCARBONYL DERIVATIVES OF HEXAHYDROINDENOPYRIDINE AND OCTAHYDROBENZOQUINOLINE 有权四氢呋喃并吡咯烷酮和甲基氢吲哚酚的芳基和杂芳基衍生物公开(公告)号：US20160272590A1
公开(公告)日：2016-09-22
申请号：US15079544
申请日：2016-03-24
IPC分类号： C07D221/10 , C07D401/04 , C07D405/04 , C07D401/12 , C07D221/16
CPC分类号： C07D221/10 , C07D221/06 , C07D221/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D417/06 , C07D471/04 , C07D498/04
摘要： The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
摘要翻译： 其中变量R1，R2，R3，R4和m如权利要求1中所定义，具有有价值的药理活性。 特别地，化合物是11β-羟基类固醇脱氢酶（HSD）1的抑制剂，因此适用于治疗和预防可受该酶抑制影响的疾病，如代谢疾病，特别是2型糖尿病，肥胖症和血脂异常 。
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