公开(公告)号：US6050990A

公开(公告)日：2000-04-18

申请号：US984892

申请日：1997-12-04

Applicant: Nikolai I. Tankovich ,  Kurt A. Dasse ,  David H. Fine ,  Paul W. Fairchild ,  Zhong-Quan Zhao ,  Mike Lefebvre ,  John Lee, Jr. ,  Jonathan L. Rolfe ,  Susan Murrell ,  Allen Hunter, II ,  Amanda J Reynolds ,  Vladimir G. Kolinko

Inventor： Nikolai I. Tankovich ,  Kurt A. Dasse ,  David H. Fine ,  Paul W. Fairchild ,  Zhong-Quan Zhao ,  Mike Lefebvre ,  John Lee, Jr. ,  Jonathan L. Rolfe ,  Susan Murrell ,  Allen Hunter, II ,  Amanda J Reynolds ,  Vladimir G. Kolinko

IPC: A61B17/00 ,  A61B18/00 ,  A61B18/20 ,  A61B19/00 ,  A61N5/06 ,  A61B17/36

CPC classification number: A61B18/203 ,  A61B2017/00026 ,  A61B2018/00005 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61B2018/00476 ,  A61B2090/0436 ,  A61B2090/049 ,  A61N5/0616 ,  A61N5/0617 ,  A61N5/062

Abstract: Methods of applying laser light to the skin, and apparatus therefor, include methods for removing hair, for synchronizing hair growth, for stimulating hair growth, for treating Herpes virus, for reducing sweat and body odor, for in situ formation of a chromophore in hair ducts, for reducing light loss at the skin surface, for grafting of hair stem cells, and for removing keloid or hypertrophic scars. The hair removal methods include controlling the proportions of photomechanical and photothermal damage by selection of laser parameters, chromophore particle size and/or pulse duration, with optional dynamic skin cooling. Additional hair removal methods include infiltrating a photoactivated drug into hair ducts and exposing the skin to sunlight or administering an anti-proliferative agent into hair ducts, for example, by encapsulating the anti-proliferative agent in a slow release vehicle. The methods of treating Herpes virus, reducing sweat or body odor, and removing keloid or hypertrophic scars include infiltrating a light-absorbing contaminant into hair ducts or other openings in the skin and illuminating the contaminated skin section. The methods for stimulating hair growth include grafting of cloned auto hair stem cells the hair ducts or administering methionine to a skin section to increase hair growth. Apparatus useful in performing these methods include devices for making a smooth optical boundary between skin and air or for dividing a light beam into a plurality of smaller light beams, and dressings for use before, during and after laser illumination.

Abstract translation: 将激光施加到皮肤上的方法及其装置包括用于去除头发的方法，用于同步毛发生长，刺激毛发生长，用于治疗疱疹病毒，减少汗液和体臭，用于原位形成发丝中的发色团 导管，用于减少皮肤表面的光损失，用于移植毛干细胞，以及用于去除瘢痕疙瘩或肥大性瘢痕。 毛发去除方法包括通过选择激光参数，发色团粒度和/或脉冲持续时间来选择动态皮肤冷却来控制光机械和光热损伤的比例。 额外的脱毛方法包括将光活化药物渗透到毛发管道中，并将皮肤暴露于阳光下或将抗增殖剂施用于毛发管道中，例如通过将抗增殖剂包封在缓释载体中。 治疗疱疹病毒，减少汗液或身体异味，以及去除瘢痕疙瘩或肥大性瘢痕的方法包括将光吸收污染物浸入毛发管道或皮肤中的其他开口并照亮被污染的皮肤部分。 用于刺激头发生长的方法包括将克隆的自发性发干细胞移植到毛发管道中，或将甲硫氨酸施用于皮肤部分以增加毛发生长。 用于执行这些方法的装置包括用于在皮肤和空气之间形成平滑的光学边界或用于将光束分成多个更小的光束的装置，以及在激光照射之前，期间和之后使用的敷料。

公开(公告)号：US6162211A

公开(公告)日：2000-12-19

申请号：US985856

申请日：1997-12-04

Applicant: Nikolai I. Tankovich ,  Kurt A. Dasse ,  Paul W. Fairchild ,  Zhong- Quan Zhao ,  Vladimir G. Kolinko

Inventor： Nikolai I. Tankovich ,  Kurt A. Dasse ,  Paul W. Fairchild ,  Zhong- Quan Zhao ,  Vladimir G. Kolinko

IPC: A61B17/00 ,  A61B18/00 ,  A61B18/20 ,  A61B19/00 ,  A61N5/06 ,  A61B18/18

CPC classification number: A61B18/203 ,  A61B2017/00026 ,  A61B2018/00005 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61B2018/00476 ,  A61B2090/0436 ,  A61B2090/049 ,  A61N5/0616 ,  A61N5/0617 ,  A61N5/062

Abstract: Methods of applying laser light to the skin, and apparatus therefor, include methods for removing hair, for bleaching hair, for transdermal drug delivery, for sensing a body function, for skin tightening, and for imaging subsurface structures are described. The hair removal methods and the hair bleaching methods include infiltrating a transparent fluid with an index of refraction greater than that of skin tissue into hair ducts to help transmit the laser light down the hair ducts. The transdermal drug delivery and body function sensing methods include exfoliating layers of the stratum corneum from a section of skin with laser light. A transdermal drug delivery patch can be placed over the exfoliated skin section, or an electrical sensor can be placed over the exfoliated skin section. The skin tightening method includes implanting a light absorbing material in the dermis of a section of skin and illuminating the skin section to disturb the dermis in such a way as to cause a healing reaction that forms more collagen fibers. The imaging system includes a confocal microscope that has been adapted to view only a time-gated portion of laser light reflected from the skin.

Abstract translation: 向皮肤施加激光的方法及其设备包括用于去除毛发，漂白毛发，用于经皮药物递送，用于感测身体功能，皮肤紧固以及用于成像地下结构的方法。 毛发去除方法和毛发漂白方法包括将折射率大于皮肤组织的透明液体渗透到毛发管道中，以帮助将激光发射到毛发管道下方。 透皮药物递送和身体功能感测方法包括从激光的皮肤部分剥离角质层。 透皮药物递送贴片可以放置在剥离的皮肤部分上，或者电传感器可以放置在剥离的皮肤部分上。 皮肤紧固方法包括将光吸收材料植入皮肤部分的真皮中并照射皮肤部分以以导致形成更多胶原纤维的愈合反应的方式干扰真皮。 成像系统包括共聚焦显微镜，其已经被适配为仅观察从皮肤反射的激光的时间门控部分。