公开(公告)号：US20100075323A1

公开(公告)日：2010-03-25

申请号：US12550207

申请日：2009-08-28

Applicant: Harn-Jing TERNG ,  Woan-Jen Lee ,  Chin-Yu Chen

Inventor： Harn-Jing TERNG ,  Woan-Jen Lee ,  Chin-Yu Chen

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: Molecular markers for lung and colorectal carcinomas and methods of using them in blood sample assays are disclosed. The method comprises measuring the expression of the markers in a blood sample from a subject for detecting the presence and/or severity of lung and/or colorectal cancer, and for monitoring and/or assessing the prognosis of the subject's response to a cancer therapy. Also disclosed are kits for detecting, diagnosing, and/or monitoring lung or colorectal carcinomas.

Abstract translation: 公开了肺和结肠直肠癌的分子标记物及其在血液样品测定中的使用方法。 该方法包括测量来自受试者的血液样品中标志物的表达，以检测肺和/或结肠直肠癌的存在和/或严重程度，以及监测和/或评估受试者对癌症治疗的反应的预后。 还公开了用于检测，诊断和/或监测肺或结肠直肠癌的试剂盒。

公开(公告)号：US09249465B2

公开(公告)日：2016-02-02

申请号：US12550207

申请日：2009-08-28

Applicant: Harn-Jing Terng ,  Woan-Jen Lee ,  Chin-Yu Chen

Inventor： Harn-Jing Terng ,  Woan-Jen Lee ,  Chin-Yu Chen

IPC: C12Q1/68 ,  C12P19/34

CPC classification number: C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: Molecular markers for lung and colorectal carcinomas and methods of using them in blood sample assays are disclosed. The method comprises measuring the expression of the markers in a blood sample from a subject for detecting the presence and/or severity of lung and/or colorectal cancer, and for monitoring and/or assessing the prognosis of the subject's response to a cancer therapy. Also disclosed are kits for detecting, diagnosing, and/or monitoring lung or colorectal carcinomas.

Abstract translation: 公开了肺和结肠直肠癌的分子标记物及其在血液样品测定中的使用方法。 该方法包括测量来自受试者的血液样品中标志物的表达，以检测肺和/或结肠直肠癌的存在和/或严重程度，以及监测和/或评估受试者对癌症治疗的反应的预后。 还公开了用于检测，诊断和/或监测肺或结肠直肠癌的试剂盒。

公开(公告)号：US20100168028A1

公开(公告)日：2010-07-01

申请号：US12718997

申请日：2010-03-07

Applicant: HARN-JING TERNG ,  YI-JEN LEE ,  WOAN-JEN LEE

Inventor： HARN-JING TERNG ,  YI-JEN LEE ,  WOAN-JEN LEE

IPC: A61K38/16 ,  C07K14/00 ,  C12P21/00 ,  A61P35/00 ,  A61P35/04

CPC classification number: C07K14/4702

Abstract: Active fragments of hcrmp1 that are capable of inhibiting cell proliferation, invasive activity, and metastasis of cancer and methods of using the same for treating cancer are disclosed. The method can also be used prior to, or in combination with, the administration a chemotherapy agent. Vectors capable of expressing an hcrmp1, variants of hcrmp1, fragments of hcrmp1 and/or variants of fragments of hcrmp1 are also disclosed.

Abstract translation: 公开了能够抑制癌症的细胞增殖，侵袭活性和转移的hcrmp1的活性片段及其用于治疗癌症的方法。 该方法也可以在施用化疗剂之前或与其组合使用。 还公开了能够表达hcrmp1，hcrmp1的变体，hcrmp1的片段和/或hcrmp1片段的变体的载体。

公开(公告)号：US20080287361A1

公开(公告)日：2008-11-20

申请号：US12076722

申请日：2008-03-21

Applicant: Harn-Jing Terng ,  Yi-Jen Lee ,  Woan-Jen Lee

Inventor： Harn-Jing Terng ,  Yi-Jen Lee ,  Woan-Jen Lee

IPC: A61K38/00 ,  C07K14/00 ,  C12N15/00 ,  A61P31/00 ,  C12N15/11

CPC classification number: C07K14/4702

Abstract: The present invention discloses a method for treating cancer by using hCRMP1 and/or active fragments thereof, as well as the active fragments of hCRMP1 that are capable of inhibiting cell proliferation, invasive activity, and metastasis of cancer. The method can also be used prior to, or in combination with, the administration a chemotherapy agent. A vector capable of expressing an hCRMP1, a variant of hCRMP1, a fragment of hCRMP1 or a variant of a fragment of hCRMP1 is also disclosed.

Abstract translation: 本发明公开了一种通过使用hCRMP1和/或其活性片段以及能够抑制癌细胞增殖，侵袭活性和转移的hCRMP1的活性片段来治疗癌症的方法。 该方法也可以在施用化疗剂之前或与其组合使用。 还公开了能够表达hCRMP1的载体，hCRMP1的变体，hCRMP1的片段或hCRMP1的片段的变体。

公开(公告)号：US07741464B2

公开(公告)日：2010-06-22

申请号：US12076722

申请日：2008-03-21

Applicant: Harn-Jing Terng ,  Yi-Jen Lee ,  Woan-Jen Lee

Inventor： Harn-Jing Terng ,  Yi-Jen Lee ,  Woan-Jen Lee

IPC: C07H21/02

CPC classification number: C07K14/4702

Abstract: The present invention discloses a method for treating cancer by using hCRMP1 and/or active fragments thereof, as well as the active fragments of hCRMP1 that are capable of inhibiting cell proliferation, invasive activity, and metastasis of cancer. The method can also be used prior to, or in combination with, the administration a chemotherapy agent. A vector capable of expressing an hCRMP1, a variant of hCRMP1, a fragment of hCRMP1 or a variant of a fragment of hCRMP1 is also disclosed.

Abstract translation: 本发明公开了一种通过使用hCRMP1和/或其活性片段以及能够抑制癌细胞增殖，侵袭活性和转移的hCRMP1的活性片段来治疗癌症的方法。 该方法也可以在施用化疗剂之前或与其组合使用。 还公开了能够表达hCRMP1的载体，hCRMP1的变体，hCRMP1的片段或hCRMP1的片段的变体。