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公开(公告)号：US20080038821A1
公开(公告)日：2008-02-14
申请号：US11663744
申请日：2005-09-09
IPC分类号： C12N5/02 , C07C229/02
CPC分类号： C12N1/02 , C08B37/0012 , C08B37/0015 , C12M33/00
摘要： A cell-sheet releasing agent of the present invention contains an aminated polyrotaxane. The polyrotaxane constituting the skeleton of the cell-releasing agent of the present invention has a structure in which cavities of a plurality of cyclic molecules are threaded onto a linear molecule and both terminals of the linear molecule have a bulky cap bonded thereto so that the cyclic molecules are not dethreaded from the linear molecule. Furthermore, the aminated polyrotaxane contained in the cell-releasing agent of the present invention is a compound in which at least some of hydroxy groups in the cyclodextrin structure contained in the polyrotaxane are each substituted with a substituent having an amino group. According to this cell-sheet releasing agent, cultured cells anchored to the surface of a container can be released without damaging the cells and without controlling the temperature.
摘要翻译： 本发明的细胞片脱模剂含有胺化聚轮烷。 构成本发明的细胞释放剂的骨架的聚轮烷具有将多个环状分子的空穴螺纹连接到直链状分子上的结构，并且直链状分子的两端具有与其结合的蓬松的盖，使得循环 分子不会从线性分子中解离出来。 此外，本发明的细胞释放剂中所含的胺化聚轮烷是其中包含在聚轮烷中的环糊精结构中的至少一些羟基各自被具有氨基的取代基取代的化合物。 根据该细胞片脱模剂，能够释放固定于容器表面的培养细胞，而不会损害细胞而不控制温度。
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公开(公告)号：US07829337B2
公开(公告)日：2010-11-09
申请号：US11663744
申请日：2005-09-09
IPC分类号： C12N5/00 , C12N5/02 , C07C229/00 , C08B30/18
CPC分类号： C12N1/02 , C08B37/0012 , C08B37/0015 , C12M33/00
摘要： A cell-sheet releasing agent of the present invention contains an aminated polyrotaxane. The polyrotaxane constituting the skeleton of the cell-releasing agent of the present invention has a structure in which cavities of a plurality of cyclic molecules are threaded onto a linear molecule and both terminals of the linear molecule have a bulky cap bonded thereto so that the cyclic molecules are not dethreaded from the linear molecule. Furthermore, the aminated polyrotaxane contained in the cell-releasing agent of the present invention is a compound in which at least some of hydroxy groups in the cyclodextrin structure contained in the polyrotaxane are each substituted with a substituent having an amino group. According to this cell-sheet releasing agent, cultured cells anchored to the surface of a container can be released without damaging the cells and without controlling the temperature.
摘要翻译： 本发明的细胞片脱模剂含有胺化聚轮烷。 构成本发明的细胞释放剂的骨架的聚轮烷具有将多个环状分子的空穴螺纹连接到直链状分子上的结构，并且直链状分子的两端具有与其结合的蓬松的盖，使得循环 分子不会从线性分子中解离出来。 此外，本发明的细胞释放剂中所含的胺化聚轮烷是其中包含在聚轮烷中的环糊精结构中的至少一些羟基各自被具有氨基的取代基取代的化合物。 根据该细胞片脱模剂，能够释放固定于容器表面的培养细胞，而不会损害细胞而不控制温度。
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