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    Fluorescent NIRF activatable probes for disease detection
    1.
    发明授权
    Fluorescent NIRF activatable probes for disease detection 有权
    用于疾病检测的荧光NIRF可激活探针

    公开(公告)号：US08834846B2

    公开(公告)日：2014-09-16

    申请号：US13101370

    申请日：2011-05-05

    申请人： Tao Ji ,  Warren M. Leevy ,  William E. McLaughlin ,  Yawfui Yong

    发明人： Tao Ji ,  Warren M. Leevy ,  William E. McLaughlin ,  Yawfui Yong

    IPC分类号： A61B5/00

    CPC分类号： G01N33/587 ,  A61K49/0485 ,  B82Y5/00 ,  B82Y15/00 ,  C12Q1/34 ,  G01N33/542

    摘要： Fluorescent activatable probes for imaging biological processes and disease detection in vitro and in vivo. There is also described a method for detecting the presence of an enzyme. A sample is contacted with a nanoparticle including a monomer, at least one cleavable spacer comprising at least one fluorescence activation site, and at least two dyes of at least two types. The cleavable spacer is attached at one end to the nanoparticle. The at least two types comprise an energy donor type and an energy acceptor type. At least one dye of one type is embedded in the nanoparticle and the cleavable spacer has at least one dye of the other type attached. The at least two dyes comprise at least one matched pair capable of fluorescence resonance energy transfer. Fluorescence is detected by exposing the sample to a light source, and detecting emitted light with a detector.

    摘要翻译： 用于成像生物过程和体外和体内疾病检测的荧光可激活探针。 还描述了检测酶的存在的方法。 将样品与包含单体的纳米颗粒，至少一个可切割间隔基包含至少一个荧光活化位点和至少两种至少两种类型的染料接触。 可切割间隔物的一端连接到纳米颗粒。 至少两种类型包括能量供体类型和能量受体类型。 至少一种一种染料被包埋在纳米颗粒中，并且可切割间隔物具有至少一种所连接的另一种类型的染料。 所述至少两种染料包含能够进行荧光共振能量转移的至少一个匹配对。 通过将样品暴露于光源并用检测器检测发射光来检测荧光。

    Method and apparatus for multi-modal imaging
    2.
    发明授权
    Method and apparatus for multi-modal imaging 有权
    多模态成像的方法和装置

    公开(公告)号：US08041409B2

    公开(公告)日：2011-10-18

    申请号：US12460010

    申请日：2009-07-10

    申请人： Warren M. Leevy ,  Gilbert Feke ,  Douglas L. Vizard

    发明人： Warren M. Leevy ,  Gilbert Feke ,  Douglas L. Vizard

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0059 ,  A01K1/031 ,  A61B5/0035 ,  A61B6/00 ,  A61B6/508 ,  A61B6/5247 ,  A61D7/04

    摘要： A method and apparatus for imaging a subject animal. The method comprises the steps of treating the animal with an x-ray contrast agent and an imaging agent; supporting the animal in an immobilized state on a support member; acquiring an x-ray anatomical image of the animal; acquiring an optical, dark-field image of the animal; and registering the x-ray anatomical image and the optical image, whereby features of the optical image can be observed in relation to features of the anatomical image.

    摘要翻译： 一种用于成像受试动物的方法和装置。 该方法包括用X射线造影剂和成像剂处理动物的步骤; 将动物以固定状态支撑在支撑构件上; 获取动物的x射线解剖图像; 获取动物的光学，暗视野图像; 并记录x射线解剖图像和光学图像，由此可以相对于解剖图像的特征观察光学图像的特征。

    FLUORESCENT NIRF ACTIVATABLE PROBES FOR DISEASE DETECTION
    4.
    发明申请
    FLUORESCENT NIRF ACTIVATABLE PROBES FOR DISEASE DETECTION 有权
    用于疾病检测的荧光近红外激活探针

    公开(公告)号：US20110293529A1

    公开(公告)日：2011-12-01

    申请号：US13101370

    申请日：2011-05-05

    申请人： Tao Ji ,  Warren M. Leevy ,  William E. McLaughlin ,  Yawfui Yong

    发明人： Tao Ji ,  Warren M. Leevy ,  William E. McLaughlin ,  Yawfui Yong

    IPC分类号： A61K49/00 ,  C12Q1/68 ,  C12Q1/37 ,  G01N33/53 ,  B82Y15/00

    CPC分类号： G01N33/587 ,  A61K49/0485 ,  B82Y5/00 ,  B82Y15/00 ,  C12Q1/34 ,  G01N33/542

    摘要： Fluorescent activatable probes for imaging biological processes and disease detection in vitro and in vivo. There is also described a method for detecting the presence of an enzyme. A sample is contacted with a nanoparticle including a monomer, at least one cleavable spacer comprising at least one fluorescence activation site, and at least two dyes of at least two types. The cleavable spacer is attached at one end to the nanoparticle. The at least two types comprise an energy donor type and an energy acceptor type. At least one dye of one type is embedded in the nanoparticle and the cleavable spacer has at least one dye of the other type attached. The at least two dyes comprise at least one matched pair capable of fluorescence resonance energy transfer. Fluorescence is detected by exposing the sample to a light source, and detecting emitted light with a detector.

    摘要翻译： 用于成像生物过程和体外和体内疾病检测的荧光可激活探针。 还描述了检测酶的存在的方法。 将样品与包含单体的纳米颗粒，至少一个可切割间隔基包含至少一个荧光活化位点和至少两种至少两种类型的染料接触。 可切割间隔物的一端连接到纳米颗粒。 至少两种类型包括能量供体类型和能量受体类型。 至少一种一种染料被包埋在纳米颗粒中，并且可切割间隔物具有至少一种所连接的另一种类型的染料。 所述至少两种染料包含能够进行荧光共振能量转移的至少一个匹配对。 通过将样品暴露于光源并用检测器检测发射光来检测荧光。

    METHOD AND APPARATUS FOR MULTI-MODAL IMAGING
    7.
    发明申请
    METHOD AND APPARATUS FOR MULTI-MODAL IMAGING 审中-公开
    用于多模式成像的方法和装置

    公开(公告)号：US20120029346A1

    公开(公告)日：2012-02-02

    申请号：US13270471

    申请日：2011-10-11

    申请人： Warren M. Leevy ,  Gilbert Feke ,  Douglas L. Vizard

    发明人： Warren M. Leevy ,  Gilbert Feke ,  Douglas L. Vizard

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0059 ,  A01K1/031 ,  A61B5/0035 ,  A61B6/00 ,  A61B6/508 ,  A61B6/5247 ,  A61D7/04

    摘要： A method and apparatus for imaging a subject animal. The method comprises the steps of treating the animal with an x-ray contrast agent and an imaging agent; supporting the animal in an immobilized state on a support member; acquiring an x-ray anatomical image of the animal; acquiring an optical, dark-field image of the animal; and registering the x-ray anatomical image and the optical image, whereby features of the optical image can be observed in relation to features of the anatomical image.

    摘要翻译： 一种用于对受试动物进行成像的方法和装置。 该方法包括用X射线造影剂和成像剂处理动物的步骤; 将动物以固定状态支撑在支撑构件上; 获取动物的x射线解剖图像; 获取动物的光学，暗视野图像; 并记录x射线解剖图像和光学图像，由此可以相对于解剖图像的特征观察光学图像的特征。

    Method and apparatus for multi-modal imaging
    8.
    发明申请
    Method and apparatus for multi-modal imaging 有权
    多模态成像的方法和装置

    公开(公告)号：US20090324048A1

    公开(公告)日：2009-12-31

    申请号：US12460010

    申请日：2009-07-10

    申请人： Warren M. Leevy ,  Gilbert Feke ,  Douglas L. Vizard

    发明人： Warren M. Leevy ,  Gilbert Feke ,  Douglas L. Vizard

    IPC分类号： G06K9/00 ,  G01N23/04 ,  G01N23/223

    CPC分类号： A61B5/0059 ,  A01K1/031 ,  A61B5/0035 ,  A61B6/00 ,  A61B6/508 ,  A61B6/5247 ,  A61D7/04

    摘要： A method and apparatus for imaging a subject animal. The method comprises the steps of treating the animal with an x-ray contrast agent and an imaging agent; supporting the animal in an immobilized state on a support member; acquiring an x-ray anatomical image of the animal; acquiring an optical, dark-field image of the animal; and registering the x-ray anatomical image and the optical image, whereby features of the optical image can be observed in relation to features of the anatomical image.

    摘要翻译： 一种用于成像受试动物的方法和装置。 该方法包括用X射线造影剂和成像剂处理动物的步骤; 将动物以固定状态支撑在支撑构件上; 获取动物的x射线解剖图像; 获取动物的光学，暗视野图像; 并记录x射线解剖图像和光学图像，由此可以相对于解剖图像的特征观察光学图像的特征。