公开(公告)号：US08729300B2

公开(公告)日：2014-05-20

申请号：US12539022

申请日：2009-08-11

申请人： Wen-Chih Chuo ,  Weichyun Wong ,  Yon-Lian Wu

发明人： Wen-Chih Chuo ,  Weichyun Wong ,  Yon-Lian Wu

IPC分类号： C07B53/00

CPC分类号： C07C51/412 ,  C07C53/128

摘要： The present invention provides a simple, safe and more efficient process for preparing metal salts of valproic acid. The process includes steps of: (i) mixing valproic acid and a metal hydroxide (either dry solid or aqueous solution) in a drier to form a reaction mixture; and (ii) removing water, which is produced during the step of mixing the valproic acid and the metal hydroxide, from the reaction mixture to obtain the desired metal salts of valproic acid.

摘要翻译： 本发明提供了制备丙戊酸金属盐的简单，安全和更有效的方法。 该方法包括以下步骤：（i）在干燥器中混合丙戊酸和金属氢氧化物（干固体或水溶液）以形成反应混合物; 和（ii）从反应混合物中除去在混合丙戊酸和金属氢氧化物的步骤期间产生的水，以获得所需的丙戊酸金属盐。