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    USE OF SPHINGOLIPIDS IN THE TREATMENT AND PREVENTION OF TYPE 2 DIABETES MELLITUS, INSULIN RESISTANCE AND METABOLIC SYNDROME
    2.
    发明申请
    USE OF SPHINGOLIPIDS IN THE TREATMENT AND PREVENTION OF TYPE 2 DIABETES MELLITUS, INSULIN RESISTANCE AND METABOLIC SYNDROME 审中-公开
    螺旋体在治疗和预防2型糖尿病，胰岛素抵抗和代谢综合征中的应用

    公开(公告)号：US20090203651A1

    公开(公告)日：2009-08-13

    申请号：US12369322

    申请日：2009-02-11

    申请人： Willem Ferdinand Nieuwenhuizen ,  Aloysius Maria Havekes ,  Josephus Jan Emeis

    发明人： Willem Ferdinand Nieuwenhuizen ,  Aloysius Maria Havekes ,  Josephus Jan Emeis

    IPC分类号： A61K31/688 ,  A61K31/16

    CPC分类号： A61K31/164 ,  A23L33/105 ,  A23L33/115 ,  A61K31/133 ,  A61K31/688

    摘要： The present invention relates to the use of sphingolipids for the preparation of a food item, a food supplement and/or a medicament for the treatment and/or prevention of insulin resistance, diabetes mellitus type 2 and/or Metabolic Syndrome. In particular, the invention relates to the use of a sphingolipid with the general formula (I): wherein Z is R3 or —CH(OH)—R3; A is sulphate, sulphonate, phosphate, phosphonate or —C(O)O—; R1 is H, hydroxyl, alditol, aldose, an alcohol, C1-C6 alkyl or amino acid; R2 is H or unsaturated or saturated (C1-C30) alkyl chain; R3 is unsaturated or saturated (C1-C30) alkyl chain; Q1 is a primary amine group (—NH2), secondary amine group (—NH—) or an amide group (—NH—CO—); and t is 0 or 1, or a precursor, a derivative or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for the prevention and/or treatment of a disorder selected from the group consisting of insulin resistance, diabetes type 2 and Metabolic Syndrome.

    摘要翻译： 本发明涉及鞘脂用于制备食品，食品补充剂和/或用于治疗和/或预防胰岛素抵抗，2型糖尿病和/或代谢综合征的药物的用途。 特别地，本发明涉及通式（I）的鞘脂的用途：其中Z为R3或-CH（OH）-R3; A是硫酸盐，磺酸盐，磷酸盐，膦酸盐或-C（O）O-; R1是H，羟基，糖醇，醛糖，醇，C 1 -C 6烷基或氨基酸; R2是H或不饱和或饱和（C1-C30）烷基链; R3是不饱和或饱和（C1-C30）烷基链; Q1是伯胺基（-NH2），仲胺基（-NH-）或酰胺基（-NH-CO-）; 和t为0或1，或其前体，衍生物或其药学上可接受的盐，用于制备用于预防和/或治疗选自胰岛素抵抗，糖尿病2型和代谢型 综合征

    USE OF SPHINGOLIPIDS IN THE TREATMENT OF TYPE 2 DIABETES MELLITUS, INSULIN RESISTANCE AND METABOLIC SYNDROME
    3.
    发明申请
    USE OF SPHINGOLIPIDS IN THE TREATMENT OF TYPE 2 DIABETES MELLITUS, INSULIN RESISTANCE AND METABOLIC SYNDROME 审中-公开
    SPHINGOLIPIDS在治疗2型糖尿病，胰岛素抵抗和代谢综合征中的应用

    公开(公告)号：US20110003772A1

    公开(公告)日：2011-01-06

    申请号：US12884607

    申请日：2010-09-17

    申请人： Willem Ferdinand Nieuwenhuizen ,  Aloysius Maria Havekes ,  Josephus Jan Emeis

    发明人： Willem Ferdinand Nieuwenhuizen ,  Aloysius Maria Havekes ,  Josephus Jan Emeis

    IPC分类号： A61K31/688 ,  A61K31/133 ,  A61P3/10

    CPC分类号： A61K31/164 ,  A23L33/105 ,  A23L33/115 ,  A61K31/133 ,  A61K31/688

    摘要： The present invention relates to the use of sphingolipids for the preparation of a food item, a food supplement and/or a medicament for the treatment of insulin resistance, diabetes mellitus type 2 and/or metabolic syndrome. In particular, the invention relates to the use of a sphingolipid with the general formula (I): wherein Z is R3 or —CH(OH)—R3; A is sulphate, sulphonate, phosphate, phosphonate or —C(O)O—; R1 is H, hydroxyl, alditol, aldose, an alcohol, C1-C6 alkyl or amino acid; R2 is H or unsaturated or saturated (C1-C30) alkyl chain; R3 is unsaturated or saturated (C1-C30) alkyl chain; Q1 is a primary amine group (—NH2), secondary amine group (—NH—) or an amide group (—NH—CO—); and t is 0 or 1, or a precursor, a derivative or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for the prevention and/or treatment of a disorder selected from the group consisting of insulin resistance, diabetes type 2 and metabolic syndrome.

    摘要翻译： 本发明涉及鞘脂用于制备食品，食品补充剂和/或用于治疗胰岛素抵抗，2型糖尿病和/或代谢综合征的药物的用途。 特别地，本发明涉及通式（I）的鞘脂的用途：其中Z为R3或-CH（OH）-R3; A是硫酸盐，磺酸盐，磷酸盐，膦酸盐或-C（O）O-; R1是H，羟基，糖醇，醛糖，醇，C 1 -C 6烷基或氨基酸; R2是H或不饱和或饱和（C1-C30）烷基链; R3是不饱和或饱和（C1-C30）烷基链; Q1是伯胺基（-NH2），仲胺基（-NH-）或酰胺基（-NH-CO-）; 和t为0或1，或其前体，衍生物或其药学上可接受的盐，用于制备用于预防和/或治疗选自胰岛素抵抗，2型糖尿病和代谢 综合征

    Sphingolipids in treatment and prevention of steatosis and of steatosis or of hepatotoxicity and its sequelae
    4.
    发明授权
    Sphingolipids in treatment and prevention of steatosis and of steatosis or of hepatotoxicity and its sequelae 有权
    鞘脂在治疗和预防脂肪变性和脂肪变性或肝毒性及其后遗症

    公开(公告)号：US07906488B2

    公开(公告)日：2011-03-15

    申请号：US11791876

    申请日：2005-11-25

    申请人： Willem Ferdinand Nieuwenhuizen

    发明人： Willem Ferdinand Nieuwenhuizen

    IPC分类号： A61K31/70 ,  A61K31/66 ,  A61K31/22

    CPC分类号： A61K45/06 ,  A23J7/00 ,  A23L33/115 ,  A61K31/133 ,  A61K31/688 ,  A61K2300/00

    摘要： The present invention relates to the use of sphingolipids for the preparation of a food item, a food supplement and/or a medicament for the prevention and/or treatment of elevated blood levels of cholesterol and triglycerides related to steatosis and hepatotoxic effects of medicaments and viral infections. In particular, the invention relates to the use of a sphingolipid such as phytosphingosine, sphingosine, sphinganine, ceramide, glycosylceramide and/or sphingomyelin, or a precursor or a derivative of a sphingolipid, or a pharmaceutically acceptable salt thereof, for the prevention and/or treatment of hepatotoxic effects such as hepatic steatosis, fibrosis and/or cirrhosis.

    摘要翻译： 本发明涉及鞘脂用于制备食品，食品补充剂和/或用于预防和/或治疗与药物和病毒的脂肪变性和肝毒性作用相关的胆固醇和甘油三酯升高的血液水平的药物的用途 感染。 特别地，本发明涉及鞘脂，例如植物鞘氨醇，鞘氨醇，鞘氨醇，神经酰胺，糖基神经酰胺和/或鞘磷脂，或神经鞘脂的前体或衍生物或其药学上可接受的盐在预防和/ 或治疗肝脏脂肪变性，纤维化和/或肝硬化等肝毒性作用。

    Use of sphingolipids for reducing high plasma cholesterol and high triacylglycerol levels
    5.
    发明授权
    Use of sphingolipids for reducing high plasma cholesterol and high triacylglycerol levels 有权
    使用鞘脂降低高血浆胆固醇和高三酰甘油水平

    公开(公告)号：US07968529B2

    公开(公告)日：2011-06-28

    申请号：US10542845

    申请日：2004-01-20

    申请人： Willem Ferdinand Nieuwenhuizen

    发明人： Willem Ferdinand Nieuwenhuizen

    IPC分类号： A61K31/66

    CPC分类号： A61K31/688 ,  A23L2/40 ,  A23L33/115 ,  A61K31/133 ,  A61K31/14 ,  A61K45/06

    摘要： The present invention is in the field of cholesterol and triglyceride-lowering methods and compositions. In particular, the present invention relates to the use of sphingolipids, more preferably phytosphingosine, sphingosine, sphinganine, ceramide, cerebroside and/or sphingomyelin for lowering the cholesterol and triglyceride levels in a subject and to the use of sphingolipids as a plasma and/or serum cholesterol and triglyceride lowering agent. The invention also encompasses methods of treatment of subjects suffering from high plasma cholesterol and triglyceride levels, as well as food items and supplements with increased sphingolipid levels.

    摘要翻译： 本发明涉及胆固醇和甘油三酯降低方法和组合物领域。 特别地，本发明涉及鞘脂，更优选植物鞘氨醇，鞘氨醇，鞘氨醇，神经酰胺，脑脊液和/或鞘磷脂用于降低受试者中胆固醇和甘油三酯水平的用途，以及使用鞘脂作为血浆和/或 血清胆固醇和甘油三酯降低剂。 本发明还包括治疗患有高血浆胆固醇和甘油三酯水平的受试者以及具有增加的鞘脂水平的食物和补充剂的方法。

    Sphingolipids in Treatment and Prevention of Steatosis and of Steatosis or of Hepatotoxicity and its Sequelae
    6.
    发明申请
    Sphingolipids in Treatment and Prevention of Steatosis and of Steatosis or of Hepatotoxicity and its Sequelae 有权
    鞘脂治疗和预防脂肪变性和脂肪变性或肝毒性及其后遗症

    公开(公告)号：US20080182902A1

    公开(公告)日：2008-07-31

    申请号：US11791876

    申请日：2005-11-25

    申请人： Willem Ferdinand Nieuwenhuizen ,  Josephus Jan Emeis ,  Aloysius Maria Havekes

    发明人： Willem Ferdinand Nieuwenhuizen ,  Josephus Jan Emeis ,  Aloysius Maria Havekes

    IPC分类号： A61K31/20 ,  A61P3/06

    CPC分类号： A61K45/06 ,  A23J7/00 ,  A23L33/115 ,  A61K31/133 ,  A61K31/688 ,  A61K2300/00

    摘要： The present invention relates to the use of sphingolipids for the preparation of a food item, a food supplement and/or a medicament for the prevention and/or treatment of hepatotoxic effects such as hepatic steatosis, fibrosis and/or cirrhosis. In particular, the invention relates to the use of a sphingolipid with the general formula (I): wherein Z is R3 or —CH(OH)—R3; A is sulphate, isulphonate, phosphate, phosphonate or —C(O)O—; R1 is H, hydroxyl, alditol, glycosyl, an alcohol, C1-C6 alkyl or amino acid; R2 is H or unsaturated or saturated (C1-C30) alkyl chain; R3 is unsaturated or saturated (C1-C30) alkyl chain; Q1 is a primary amine group (—NH2), secondary amine group (—NH—) or an amide group (—NH—CO—); and t is 0 or 1, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for the prevention and/or treatment of hepatotoxic effects such as hepatic steatosis, fibrosis and/or cirrhosis.

    摘要翻译： 本发明涉及鞘脂用于制备食品，食品补充剂和/或用于预防和/或治疗肝脏脂肪变性，纤维化和/或肝硬化等肝毒性作用的药物的用途。 特别地，本发明涉及通式（I）的鞘脂的用途：其中Z为R3或-CH（OH）-R3; A是硫酸盐，异硫酸盐，磷酸盐，膦酸盐或-C（O）O-; R1是H，羟基，糖醇，糖基，醇，C1-C6烷基或氨基酸; R2是H或不饱和或饱和（C1-C30）烷基链; R3是不饱和或饱和（C1-C30）烷基链; Q1是伯胺基（-NH2），仲胺基（-NH-）或酰胺基（-NH-CO-）; 和t为0或1，或其药学上可接受的盐，用于制备用于预防和/或治疗肝脏脂肪变性，纤维化和/或肝硬化等肝毒性作用的药物。

    Sphingolipids for improvement of the composition of the intestinal flora
    7.
    发明授权
    Sphingolipids for improvement of the composition of the intestinal flora 失效
    鞘脂用于改善肠道菌群的组成

    公开(公告)号：US08703172B2

    公开(公告)日：2014-04-22

    申请号：US10542838

    申请日：2004-01-20

    申请人： Willem Ferdinand Nieuwenhuizen

    发明人： Willem Ferdinand Nieuwenhuizen

    IPC分类号： A61K47/00

    CPC分类号： A61K31/688 ,  A23L33/115 ,  A61K31/13

    摘要： The present invention relates to a method for improving the composition of the intestinal flora, to a food comprising a sphingolipid for use in such a method, to methods for the preparation of such a food and to the use of sphingolipids for the preparation of a medicine for improving the composition of the intestinal flora. More in particular, the present invention relates to a method and food in which a sphingolipid chosen from the group consisting of phytosphingosine, sphingosine, lysosphingomyelin and sphinganine, or a precursor, a derivative, or suitable salt thereof is used.

    摘要翻译： 本发明涉及一种改善肠道菌群组成的方法，包括用于这种方法的鞘脂的食品，制备这种食物的方法以及鞘脂用于制备药物的用途 用于改善肠道菌群的组成。 更具体地，本发明涉及一种方法和食品，其中使用选自植物鞘氨醇，鞘氨醇，溶血鞘磷脂和二氢鞘氨醇的鞘脂或其前体，衍生物或其合适的盐。