Gangliosides with a modified acyl function
    8.
    发明申请
    Gangliosides with a modified acyl function 失效
    具有改性酰基功能的神经节苷脂

    公开(公告)号:US20050075310A1

    公开(公告)日:2005-04-07

    申请号:US10497173

    申请日:2003-05-27

    摘要: The invention relates to a ganglioside mixture, consisting of gangliosides, of the following general formula: (sugar)-OCH2—CH(—NH—CO—R1)—CH(OH)—CH=CH-R2, wherein (sugar) represents a sugar radical, the group —CO—R1 represents an acyl-fatty acid which is bonded to the radical of the molecule in the form of an amide, R1 represents a straight saturated alkyl radical having at least 10 C-atoms and R2 represents a straight, saturated alkyl radical having at least 10 C-atoms or a straight alkenyl radical having at least 10 C-atoms and one, two or three double bond(s). Said mixture is characterised in that at least 10 wt. % of the gangliosides of the general formula I are of the group —CO—R1 and the acyl-fatty acids are a C20:0 fatty acid. Said mixtures exhibit an improved biological activity.

    摘要翻译: 本发明涉及神经节苷脂混合物,由神经节苷脂组成,具有以下通式:(糖)-OCH 2 -CH(-NH-CO-R 1)-CH(OH)-CH = CH-R 2 ,其中(糖)表示糖基,基团-CO-R 1表示与酰基形式的分子基团结合的酰基脂肪酸,R 1表示直链饱和烷基 具有至少10个C原子的基团和R 2表示具有至少10个C原子的直链饱和烷基或具有至少10个C原子和一个,两个或三个双键的直链烯基, 。 所述混合物的特征在于,至少10wt。 通式I的神经节苷脂的%为-CO-R 1基团,酰基脂肪酸为C20:0脂肪酸。 所述混合物表现出改善的生物活性。