公开(公告)号：US20080119685A1

公开(公告)日：2008-05-22

申请号：US11715597

申请日：2007-03-08

Applicant: Akiko Kumagai ,  William Dunphy

Inventor： Akiko Kumagai ,  William Dunphy

IPC: A61N5/00 ,  A61K49/00 ,  C07K14/00 ,  C12N5/06 ,  G01N33/53

CPC classification number: G01N33/5011 ,  G01N2333/912

Abstract: ATR kinase is a key regulator of checkpoint responses to incompletely replicated and damaged DNA. Without this checkpoint, cells will enter mitosis prematurely, likely resulting in cell death. The invention provides methods and reagents to either block or activate the activation of the ATR kinase checkpoint, through, for example, either blocking or activating the expression of an ATR activator TopBP1. The invention also provides screening methods to identify additional ToBP1 inhibitors or activators that may be used to modulate the activity of the ATR checkpoint.

Abstract translation: ATR激酶是对不完全复制和损伤的DNA的检查点反应的关键调节剂。 没有这个检查点，细胞会过早进入有丝分裂，可能导致细胞死亡。 本发明提供了通过例如阻断或激活ATR激活剂TopBP1的表达阻断或激活ATR激酶检查点的活化的方法和试剂。 本发明还提供筛选方法以鉴定可用于调节ATR检查点的活性的额外的ToBP1抑制剂或活化剂。

公开(公告)号：US20150355003A1

公开(公告)日：2015-12-10

申请号：US14760425

申请日：2014-01-10

Applicant: Bradley SAEGER ,  William WRIGHT ,  William DUNPHY ,  Andrew RYDER ,  FEEDLOGIC CORPORATION

Inventor： Bradley Saeger ,  William Wright ,  William Dunphy ,  Andrew Ryder

IPC: G01F1/66

CPC classification number: G01F1/66 ,  G01F1/704 ,  G01F25/0007 ,  G01P13/0073 ,  G01P15/00

Abstract: Some system embodiments may include a flow monitor and a communication hub. The flow monitor may be configured to be mounted on a feed line. The flow monitor may include an accelerometer configured to detect vibration of the feed line. The communication hub may be configured to wirelessly communicate with the flow monitor, to receive accelerometer data from the flow monitor, and use the accelerometer data to communicate flow status information through a network to a user.

Abstract translation: 一些系统实施例可以包括流量监视器和通信集线器。 流量监视器可以被配置为安装在馈送线上。 流量监视器可以包括被配置为检测馈送线的振动的加速度计。 通信集线器可以被配置为与流量监视器无线通信，以从流量监视器接收加速度计数据，并且使用加速度计数据通过网络将流量状态信息传达给用户。

公开(公告)号：US08080531B2

公开(公告)日：2011-12-20

申请号：US12220982

申请日：2008-07-30

Applicant: Akiko Kumagai ,  William Dunphy

Inventor： Akiko Kumagai ,  William Dunphy

IPC: C12N15/11 ,  C07H21/02 ,  C07H21/04

CPC classification number: G01N33/5011 ,  G01N2333/912

Abstract: ATR kinase is a key regulator of checkpoint responses to incompletely replicated and damaged DNA. Without this checkpoint, cells will enter mitosis prematurely, likely resulting in cell death. The invention provides methods and reagents to either block or activate the activation of the ATR kinase checkpoint, through, for example, either blocking or activating the expression of an ATR activator TopBP1. The invention also provides screening methods to identify additional ToBP1 inhibitors or activators that may be used to modulate the activity of the ATR checkpoint.

Abstract translation: ATR激酶是对不完全复制和损伤的DNA的检查点反应的关键调节剂。 没有这个检查点，细胞会过早进入有丝分裂，可能导致细胞死亡。 本发明提供了通过例如阻断或激活ATR激活剂TopBP1的表达阻断或激活ATR激酶检查点的活化的方法和试剂。 本发明还提供筛选方法以鉴定可用于调节ATR检查点的活性的额外的ToBP1抑制剂或活化剂。

公开(公告)号：US07098007B2

公开(公告)日：2006-08-29

申请号：US10227610

申请日：2002-08-22

Applicant: William Dunphy ,  Akiko Kymagai ,  Zijian Guo

Inventor： William Dunphy ,  Akiko Kymagai ,  Zijian Guo

IPC: C12P21/00 ,  C12N15/63 ,  C12N15/85 ,  C07H15/11

CPC classification number: C12N9/12 ,  A01K2217/05 ,  A61K39/00

Abstract: The present invention provides compositions of ATR nucleic acids and proteins, as well as methods of using said compositions in screening assays. The invention further provides antibodies and transgenic animals based on the ATR compositions.

公开(公告)号：US20090098111A1

公开(公告)日：2009-04-16

申请号：US12220982

申请日：2008-07-30

Applicant: Akiko Kumagai ,  William Dunphy

Inventor： Akiko Kumagai ,  William Dunphy

IPC: A61K39/395 ,  A61K31/7088 ,  A61K38/00 ,  G01N33/53 ,  C07K7/00 ,  C12N15/00 ,  A61K38/43

CPC classification number: G01N33/5011 ,  G01N2333/912

Abstract: ATR kinase is a key regulator of checkpoint responses to incompletely replicated and damaged DNA. Without this checkpoint, cells will enter mitosis prematurely, likely resulting in cell death. The invention provides methods and reagents to either block or activate the activation of the ATR kinase checkpoint, through, for example, either blocking or activating the expression of an ATR activator TopBP1. The invention also provides screening methods to identify additional ToBP1 inhibitors or activators that may be used to modulate the activity of the ATR checkpoint.

Abstract translation: ATR激酶是对不完全复制和损伤的DNA的检查点反应的关键调节剂。 没有这个检查点，细胞会过早进入有丝分裂，可能导致细胞死亡。 本发明提供了通过例如阻断或激活ATR激活剂TopBP1的表达阻断或激活ATR激酶检查点的活化的方法和试剂。 本发明还提供筛选方法以鉴定可用于调节ATR检查点的活性的额外的ToBP1抑制剂或活化剂。

公开(公告)号：US5679333A

公开(公告)日：1997-10-21

申请号：US738048

申请日：1996-10-25

Applicant: Brian William Dunphy

Inventor： Brian William Dunphy

IPC: A01N1/00 ,  A61L9/00

CPC classification number: A01N1/00

Abstract: Formaldehyde-free tissue preservative compositions are useful in the fields of mortuary science and histology. The compositions disinfect and preserve animal (including human) tissues and remains, yet avoid the use of formaldehyde and formalin--potentially hazardous materials that are undergoing increasing regulatory review. A trio of compositions for use in embalming human bodies is disclosed, as is a composition for use in histological preservation.

Abstract translation: 无甲醛组织防腐剂组合物可用于太平间科学和组织学领域。 组合物消毒和保存动物（包括人）组织和遗骸，但避免使用正在进行越来越多的管理审查的甲醛和福尔马林潜在危险物质。 公开了三种用于防腐人体的组合物，以及用于组织保存的组合物。