公开(公告)号：US06225101B1

公开(公告)日：2001-05-01

申请号：US09337386

申请日：1999-06-21

申请人： Paul R. Mueller ,  Thomas R. Coleman ,  Akiko Kumagai ,  William G. Dunphy

发明人： Paul R. Mueller ,  Thomas R. Coleman ,  Akiko Kumagai ,  William G. Dunphy

IPC分类号： C12N912

CPC分类号： C12N9/1205

摘要： The present invention provides a threonine/tyrosine kinase, Myt1, that phosphorylates the cyclin-dependent kinase, Cdc2, to provide regulation of the cell cycle at the G2/M interphase. Also included are polynucleotides encoding Myt1 polypeptide and antibodies that bind to Myt1. Methods of modulating Myt1 for preventing premature entry of the cell into mitosis or to accelerate entry into mitosis are also provided, as are methods for identifying agents that modulate Myt1.

摘要翻译： 本发明提供苏氨酸/酪氨酸激酶Myt1，其使细胞周期蛋白依赖性激酶Cdc2磷酸化，以提供G2 / M中间期细胞周期的调节。 还包括编码Myt1多肽的多核苷酸和结合Myt1的抗体。 还提供了调节Myt1以防止细胞过早进入有丝分裂或加速进入有丝分裂的方法，以及用于鉴定调节Myt1的药剂的方法。

公开(公告)号：US07037678B2

公开(公告)日：2006-05-02

申请号：US09982091

申请日：2001-10-17

申请人： Akiko Kumagai ,  William G. Dunphy

发明人： Akiko Kumagai ,  William G. Dunphy

IPC分类号： C12P21/02 ,  C07H21/04 ,  C12N1/00 ,  C12N5/10 ,  C12N15/00

CPC分类号： C07K14/4738 ,  A61K38/00 ,  G01N2500/10

摘要： Claspin proteins and nucleotides encoding Claspin proteins are provided. Also provided is a method for identifying a compound that modulates cell cycle progression. A method is further provided for modulating cell cycle progression.

公开(公告)号：US06387642B2

公开(公告)日：2002-05-14

申请号：US09846922

申请日：2001-04-30

申请人： Paul R. Mueller ,  Thomas R. Coleman ,  Akiko Kumagai ,  William G. Dunphy

发明人： Paul R. Mueller ,  Thomas R. Coleman ,  Akiko Kumagai ,  William G. Dunphy

IPC分类号： C12Q148

CPC分类号： C12N9/1205

摘要： The present invention provides a threonine/tyrosine kinase, Myt1, that phosphorylates the cyclin-dependent kinase, Cdc2, to provide regulation of the cell cycle at the G2/M interphase. Also included are polynucleotides encoding Myt1 polypeptide and antibodies that bind to Myt1. Methods of modulating Myt1 for preventing premature entry of the cell into mitosis or to accelerate entry into mitosis are also provided, as are methods for identifying agents that modulate Myt1.

摘要翻译： 本发明提供苏氨酸/酪氨酸激酶Myt1，其使细胞周期蛋白依赖性激酶Cdc2磷酸化，以提供G2 / M中间期细胞周期的调节。 还包括编码Myt1多肽的多核苷酸和结合Myt1的抗体。 还提供了调节Myt1以防止细胞过早进入有丝分裂或加速进入有丝分裂的方法，以及用于鉴定调节Myt1的药剂的方法。

公开(公告)号：US6020194A

公开(公告)日：2000-02-01

申请号：US942001

申请日：1997-10-01

申请人： Paul R. Mueller ,  Thomas R. Coleman ,  Akiko Kumagai ,  William G. Dunphy

发明人： Paul R. Mueller ,  Thomas R. Coleman ,  Akiko Kumagai ,  William G. Dunphy

IPC分类号： C12N9/12 ,  C12N5/10 ,  C12N1/00 ,  C12N1/16 ,  C12N15/11

CPC分类号： C12N9/1205

摘要： The present invention provides a threonine/tyrosine kinase, Myt1, that phosphorylates the cyclin-dependent kinase, Cdc2, to provide regulation of the cell cycle at the G2/M interphase. Also included are polynucleotides encoding Myt1 polypeptide and antibodies that bind to Myt1. Methods of modulating Myt1 for preventing premature entry of the cell into mitosis or to accelerate entry into mitosis are also provided, as are methods for identifying agents that modulate Myt1.

摘要翻译： 本发明提供苏氨酸/酪氨酸激酶Myt1，其使细胞周期蛋白依赖性激酶Cdc2磷酸化，以提供G2 / M中间期细胞周期的调节。 还包括编码Myt1多肽的多核苷酸和结合Myt1的抗体。 还提供了调节Myt1以防止细胞过早进入有丝分裂或加速进入有丝分裂的方法，以及用于鉴定调节Myt1的药剂的方法。

公开(公告)号：US06593110B2

公开(公告)日：2003-07-15

申请号：US09849617

申请日：2001-05-04

申请人： Zijian Guo ,  William G. Dunphy

发明人： Zijian Guo ,  William G. Dunphy

IPC分类号： C12P2106

CPC分类号： C07K14/4738 ,  A01K2217/05

摘要： The present invention provides polypeptides (Cds1) that are involved in regulating the progression of the cell cycle. The polypeptides are activated by double-stranded DNA and phosphorylated in response to the presence of double-stranded DNA. Also provided are polynucleotides encoding Cds1 polypeptidese and methods for modulating cell cycle progression in a cell.