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公开(公告)号：US06225101B1
公开(公告)日：2001-05-01
申请号：US09337386
申请日：1999-06-21
IPC分类号： C12N912
CPC分类号： C12N9/1205
摘要： The present invention provides a threonine/tyrosine kinase, Myt1, that phosphorylates the cyclin-dependent kinase, Cdc2, to provide regulation of the cell cycle at the G2/M interphase. Also included are polynucleotides encoding Myt1 polypeptide and antibodies that bind to Myt1. Methods of modulating Myt1 for preventing premature entry of the cell into mitosis or to accelerate entry into mitosis are also provided, as are methods for identifying agents that modulate Myt1.
摘要翻译： 本发明提供苏氨酸/酪氨酸激酶Myt1，其使细胞周期蛋白依赖性激酶Cdc2磷酸化，以提供G2 / M中间期细胞周期的调节。 还包括编码Myt1多肽的多核苷酸和结合Myt1的抗体。 还提供了调节Myt1以防止细胞过早进入有丝分裂或加速进入有丝分裂的方法，以及用于鉴定调节Myt1的药剂的方法。
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公开(公告)号：US06387642B2
公开(公告)日：2002-05-14
申请号：US09846922
申请日：2001-04-30
IPC分类号： C12Q148
CPC分类号： C12N9/1205
摘要： The present invention provides a threonine/tyrosine kinase, Myt1, that phosphorylates the cyclin-dependent kinase, Cdc2, to provide regulation of the cell cycle at the G2/M interphase. Also included are polynucleotides encoding Myt1 polypeptide and antibodies that bind to Myt1. Methods of modulating Myt1 for preventing premature entry of the cell into mitosis or to accelerate entry into mitosis are also provided, as are methods for identifying agents that modulate Myt1.
摘要翻译： 本发明提供苏氨酸/酪氨酸激酶Myt1，其使细胞周期蛋白依赖性激酶Cdc2磷酸化，以提供G2 / M中间期细胞周期的调节。 还包括编码Myt1多肽的多核苷酸和结合Myt1的抗体。 还提供了调节Myt1以防止细胞过早进入有丝分裂或加速进入有丝分裂的方法，以及用于鉴定调节Myt1的药剂的方法。
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公开(公告)号：US6020194A
公开(公告)日：2000-02-01
申请号：US942001
申请日：1997-10-01
CPC分类号： C12N9/1205
摘要： The present invention provides a threonine/tyrosine kinase, Myt1, that phosphorylates the cyclin-dependent kinase, Cdc2, to provide regulation of the cell cycle at the G2/M interphase. Also included are polynucleotides encoding Myt1 polypeptide and antibodies that bind to Myt1. Methods of modulating Myt1 for preventing premature entry of the cell into mitosis or to accelerate entry into mitosis are also provided, as are methods for identifying agents that modulate Myt1.
摘要翻译： 本发明提供苏氨酸/酪氨酸激酶Myt1，其使细胞周期蛋白依赖性激酶Cdc2磷酸化，以提供G2 / M中间期细胞周期的调节。 还包括编码Myt1多肽的多核苷酸和结合Myt1的抗体。 还提供了调节Myt1以防止细胞过早进入有丝分裂或加速进入有丝分裂的方法，以及用于鉴定调节Myt1的药剂的方法。
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4.发明授权Method of preparing nucleic acids having an undefined nucleotide sequence amplification 失效制备具有未定义核苷酸序列扩增的核酸的方法
公开(公告)号：US5599696A
公开(公告)日：1997-02-04
申请号：US323571
申请日：1994-10-17
CPC分类号： C12Q1/6855
摘要： A method for amplifying specific nucleic acid fragments having an undefined nucleotide sequence wherein said nucleic acid fragments are present in a mixture of nucleic acids. Blunt ended linkers with known nucleotide sequences are used in the method to isolate and distinguish the specific undefined nucleic acid fragments from the rest of the nucleic acid. Primers which hybridize with the known linker are then used as part of a polymerase chain reaction procedure to amplify the specific nucleic acid fragment which includes the undefined nucleotide sequence.
摘要翻译： 用于扩增具有未定义核苷酸序列的特异性核酸片段的方法，其中所述核酸片段存在于核酸混合物中。 具有已知核苷酸序列的平端连接物用于分离和区分特定未定义核酸片段与其余核酸的方法。 然后将与已知接头杂交的引物用作聚合酶链反应程序的一部分，以扩增包含未定义的核苷酸序列的特异性核酸片段。
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公开(公告)号：US08303244B2
公开(公告)日：2012-11-06
申请号：US11150864
申请日：2005-06-10
IPC分类号： F01D11/08
CPC分类号： F04D29/668 , F04D29/526
摘要： The invention concerns an engine-mounted fan shroud for use in a vehicle that has a shroud body supported by a vehicle engine, including an outer ring made of a first material having a first stiffness, and a bodyside seal extending from and being integral with the outer ring, with the bodyside seal being made of a second material having a second stiffness that is less than the first stiffness. The bodyside seal fits into and seals around a seal opening in a body-mounted shroud that is mounted to radiator support structure.
摘要翻译： 本发明涉及一种用于车辆中的发动机安装的风扇罩，其具有由车辆发动机支撑的护罩主体，包括由具有第一刚度的第一材料制成的外圈和从该第一材料延伸并与之成一体的体侧密封件 外环，身体密封件由具有小于第一刚度的第二刚度的第二材料制成。 身体密封装置安装在散热器支撑结构上的身体安装的护罩中并且密封在密封开口周围。
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