公开(公告)号：US06294572B1

公开(公告)日：2001-09-25

申请号：US09346583

申请日：1999-07-02

申请人： Christopher Williamson ,  William James White ,  Vipulkumar Patel

发明人： Christopher Williamson ,  William James White ,  Vipulkumar Patel

IPC分类号： A61K31351

CPC分类号： C07D309/28

摘要： Two useful crystal hydrates of 5-acetamido-2,3,4,5-tetradeoxy-4-guanidino-D-glycero-D-galacto-non-2-enopyranosonic acid have either a low or high aspect ratio. These crystalline N-acetyl neurominic acid derivatives are favored for pharmaceutical formulation because of their physical properties. For example, the low aspect ratio crystal has good flow properties, and the high aspect ratio crystal has a stable water content over time.

摘要翻译： 5-乙酰氨基-2,3,4,5-四脱氧-4-胍基-D-甘油基-D-半乳-N-壬-2-吡喃糖酸的两种有用的晶体水合物具有低或高纵横比。 这些结晶N-乙酰神经氨酸衍生物由于其物理性质而优于药物制剂。 例如，低纵横比的晶体具有良好的流动特性，高长宽比的晶体随着时间的推移具有稳定的水分含量。