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公开(公告)号：US08887499B2
公开(公告)日：2014-11-18
申请号：US13172320
申请日：2011-06-29
CPC分类号： F15B11/055 , F15B2211/20553 , F15B2211/20576 , F15B2211/27 , F15B2211/613 , F15B2211/625 , F15B2211/6346 , F15B2211/7053
摘要： A method for overpressure control in a hydraulic system having multiple hydraulic pumps, with each hydraulic pump being connected by a respective hydraulic circuit for actuating a single respective hydraulic actuator, includes actuating a first variable displacement hydraulic pump, the first hydraulic pump being fluidly linked by a first hydraulic circuit to a first hydraulic actuator for powering the first hydraulic actuator. Upon detecting a pressure that exceeds a predetermined threshold pressure, the flow rate of the first hydraulic pump is electronically modified to a second flow rate lower than the first flow rate whereby the pressure in the first hydraulic circuit is reduced to a pressure that is below the predetermined threshold pressure.
摘要翻译： 一种用于具有多个液压泵的液压系统中的超压控制的方法，每个液压泵通过相应的液压回路连接，用于致动单个相应的液压致动器，包括致动第一可变排量液压泵，第一液压泵通过 向第一液压致动器供给第一液压致动器的第一液压回路。 在检测到超过预定阈值压力的压力时，第一液压泵的流量被电子地修改为低于第一流量的第二流量，由此第一液压回路中的压力降低到低于 预定阈值压力。
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公开(公告)号：US20120180677A1
公开(公告)日：2012-07-19
申请号：US13434402
申请日：2012-03-29
IPC分类号： B41F31/04
CPC分类号： B41F17/001
摘要： A doctor assembly for a pad printing system includes a body and a doctor blade. The body has an outer surface and an opposite inner surface that defines a passageway through the body. The inner surface engages a removable pre-filled ink cup to secure the ink cup to the body. The inner surface directs ink from the ink cup through the passageway toward an ink-receiving surface of a cliché device. The doctor blade is coupled with the body and engages the cliché device. The doctor blade wipes the ink along the cliché device as the body laterally moves relative to the cliché device. The doctor blade is coupled with the body such that the doctor blade is laterally spaced apart from the inner surface of the body.
摘要翻译： 用于移印系统的刮刀组件包括主体和刮刀。 主体具有外表面和相对的内表面，其限定穿过主体的通道。 内表面接合可移除的预先填充的墨水杯以将墨水杯固定到身体上。 内表面将油墨从墨杯引导通过通道朝向陈设装置的墨接收表面。 刮刀与主体联接并与陈词滥调装置接合。 当身体相对于陈设装置横向移动时，刮刀沿着陈腔装置擦拭墨水。 刮刀与主体联接，使得刮刀与主体的内表面横向间隔开。
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公开(公告)号：US06180639B2
公开(公告)日：2001-01-30
申请号：US07835964
申请日：1992-02-20
申请人： Jonathan Allan Coates , Ian Martin Mutton , Charles Richard Penn , Christopher Williamson , Richard Storer
发明人： Jonathan Allan Coates , Ian Martin Mutton , Charles Richard Penn , Christopher Williamson , Richard Storer
IPC分类号： A61K31505
CPC分类号： A61K31/7068 , A61K31/505 , A61K31/506 , A61K31/70 , A61K45/06 , C07D411/04 , A61K2300/00
摘要： (−)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one, its pharmaceutically acceptable derivatives, pharmaceutical formulation thereof, methods for its preparation and its uses as an antiviral agent are described.
摘要翻译： （ - ） - 4-氨基-1-（2-羟甲基-1,3-氧硫杂环戊烷-5-基） - （1H） - 嘧啶-2-酮，其药学上可接受的衍生物，其药物制剂，其制备方法和 描述其作为抗病毒剂的用途。
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公开(公告)号：US08484015B1
公开(公告)日：2013-07-09
申请号：US12780651
申请日：2010-05-14
CPC分类号： G06F17/30693 , G06F17/30654
摘要： An answer engine determines an entity related to a query from a user in a system designed for computation, search, or other activities involving the processing of queries. The system determines whether an entity page for the entity is stored in an answers database and, if so, retrieves and displays the stored entity page. If there is no stored entity page for the entity, the answer engine generates and displays an answer to the query and may optionally store the answer as an entity page. Additionally, the answer engine may pre-generate and store entity pages according to algorithmic variation of received queries and/or according to information received from external sources.
摘要翻译： 答案引擎在用于计算，搜索或涉及处理查询的其他活动的系统中确定与来自用户的查询相关的实体。 系统确定实体的实体页面是否存储在答案数据库中，如果是，则检索并显示存储的实体页面。 如果实体没有存储的实体页面，则答案引擎生成并显示对查询的答案，并且可以可选地将答案存储为实体页面。 此外，应答引擎可以根据接收到的查询的算法变化和/或根据从外部源接收的信息来预生成和存储实体页面。
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5.发明授权Substituted pyrimidin-2-ones, the salts thereof, pharmaceutical compositions containing them and a method therefor 失效取代的嘧啶-2-酮，其盐，含有它们的药物组合物及其方法
公开(公告)号：US4650800A
公开(公告)日：1987-03-17
申请号：US496093
申请日：1983-05-19
申请人： Gordon H. Phillipps , Christopher Williamson , Ian P. Steeples , Brian M. Bain , Raymond A. Borella
发明人： Gordon H. Phillipps , Christopher Williamson , Ian P. Steeples , Brian M. Bain , Raymond A. Borella
IPC分类号： A61K31/505 , A61P35/00 , A61P35/02 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
CPC分类号： C07D409/06 , C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06
摘要： Compounds of the general formula: ##STR1## wherein X represents a halogen atom or a trifluoromethyl group; R.sup.1 represents a hydrogen atom or a lower alkyl group and Het represents an optionally substituted C-attached 5-7 membered aromatic heterocyclic ring which ring contains one or more heteroatoms selected from O, N and S and optionally carries a fused ring and where an acidic or basic group is present, the salts thereof have been found to possess excellent metaphase arresting ability and are of use in combating abnormal cell proliferation. Thus a knowledge of the cell division cycles of the normal and abnormal cells enables a cytotoxic drug to be administered while the abnormal cells are in a phase susceptible to attack and while the normal cells are in a non-susceptible phase.The compounds of the invention are prepared by alkylation, deprotection of a protected keto group, oxidation or electrophilic halogenation.
摘要翻译： 通式的化合物：其中X表示卤素原子或三氟甲基; R1表示氢原子或低级烷基，Het表示任选取代的C连接的5-7元芳族杂环，该环含有一个或多个选自O，N和S的杂原子，并且任选地带有稠环，并且其中酸性 或碱性基团，其盐被发现具有优异的中期阻滞能力，并且可用于对抗异常细胞增殖。 因此，正常和异常细胞的细胞分裂周期的知识使得能够施用细胞毒性药物，同时异常细胞处于易受攻击的阶段，而正常细胞处于非易感相。 本发明的化合物是通过烷基化，保护的酮基的脱保护，氧化或亲电卤化来制备的。
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6.发明授权Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, pharmaceutical compositions containing them and a method therefor 失效取代的嘧啶-2-酮，其盐，其制备方法，含有它们的药物组合物及其方法
公开(公告)号：US4636509A
公开(公告)日：1987-01-13
申请号：US498723
申请日：1983-05-27
IPC分类号： A61K31/505 , A61P35/00 , A61P35/02 , C07D239/36
CPC分类号： C07D239/36
摘要： Compounds of the general formula: ##STR1## (wherein X represents a halogen atom or a trifluoromethyl group; R.sup.1 represents an optionally substituted C.sub.6-10 carbocyclic aromatic group; and R.sup.2 represents a hydrogen atom or a lower alkyl, C.sub.7-16 aralkyl or C.sub.6-10 aryl group or the group COR.sup.1a, in which R.sup.1a is as defined for R.sup.1, R.sup.1 and R.sup.1a being the same or different) and where an acidic or basic group is present, the salts thereof have been found to possess excellent metaphase arresting ability and are of use in combating abnormal cell proliferation. Thus a knowledge of the cell division cycles of the normal and abnormal cells enables a cytotoxic drug to be administered while the abnormal cells are in a phase susceptible to attack and while the normal cells are in a non-susceptible phase.The compounds of the invention are prepared by alkylation, deprotection of a protected keto group, oxidation or electrophilic halogenation.Pharmaceutical compositions containing the compounds of formula I, and where appropriate, the physiologically compatible salts thereof; and methods for the use of the compounds are described and claimed.
摘要翻译： 通式为的化合物：其中X表示卤原子或三氟甲基; R 1表示任选取代的C 6-10碳环芳基; R 2表示氢原子或低级烷基，C 7-16芳烷基或 C6-10芳基或COR1a基团，其中R1a如R1所定义，R1和R1a相同或不同），并且其中存在酸性或碱性基团时，其盐被发现具有优异的中期阻滞能力 并且可用于对抗异常细胞增殖。 因此，正常和异常细胞的细胞分裂周期的知识使得能够施用细胞毒性药物，同时异常细胞处于易受攻击的阶段，而正常细胞处于非易感相。 本发明的化合物是通过烷基化，保护的酮基的脱保护，氧化或亲电卤化来制备的。 含有式I化合物和适当时其生理上相容的盐的药物组合物; 并描述和要求保护化合物的使用方法。
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公开(公告)号：US4335121A
公开(公告)日：1982-06-15
申请号：US234113
申请日：1981-02-13
CPC分类号： C07J71/0031 , C07J3/005 , C07J31/006 , C07J41/0038 , C07J71/001 , C07J71/0015
摘要： Compounds of the formula ##STR1## wherein R.sup.1 represents a fluoro-, chloro- or bromo-methyl group or a 2'-fluoroethyl group, R.sup.2 represents a group COR.sup.6 where R.sup.6 is a C.sub.1-3 alkyl group or OR.sup.2 and R.sup.3 together form a 16.alpha.,17.alpha.-isopropylidenedioxy group; R.sup.3 represents a hydrogen atom, a methyl group (which may be in either the .alpha.- or .beta.-configuration) or a methylene group; R.sup.4 represents a hydrogen, chlorine or fluorine atom; R.sup.5 represents a hydrogen or fluorine atom and symbol represents a single or double bond have good anti-inflammatory activity, particularly on topical applications.The compounds of formula I are prepared by esterification, halogenation, reduction, deprotection and reaction at a 9,11-double bond to form a 9.alpha.-halo-11.beta.-hydroxy grouping.Pharmaceutical compositions containing the compounds of formula I and methods for the use of the compounds are described and claimed.
摘要翻译： 式（I）的化合物其中R 1表示氟，氯或溴甲基或2'-氟乙基，R 2表示基团COR 6，其中R 6是C 1-3烷基或OR 2和R 3 一起形成16α，17α-异亚丙基二氧基; R 3表示氢原子，甲基（其可以是α或β构型）或亚甲基; R4表示氢，氯或氟原子; R5表示氢或氟原子，符号表示单键或双键具有良好的抗炎活性，特别是局部应用。 式I的化合物通过在9,11-双键进行酯化，卤化，还原，脱保护和反应来制备，以形成9α-卤代-11β-羟基。 描述并要求保护含有式I化合物的药物组合物和使用该化合物的方法。
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8.发明授权公开(公告)号：US08955433B2
公开(公告)日：2015-02-17
申请号：US13434402
申请日：2012-03-29
CPC分类号： B41F17/001
摘要： A doctor assembly for a pad printing system includes a body and a doctor blade. The body has an outer surface and an opposite inner surface that defines a passageway through the body. The inner surface engages a removable pre-filled ink cup to secure the ink cup to the body. The inner surface directs ink from the ink cup through the passageway toward an ink-receiving surface of a cliché device. The doctor blade is coupled with the body and engages the cliché device. The doctor blade wipes the ink along the cliché device as the body laterally moves relative to the cliché device. The doctor blade is coupled with the body such that the doctor blade is laterally spaced apart from the inner surface of the body.
摘要翻译： 用于移印系统的刮刀组件包括主体和刮刀。 主体具有外表面和相对的内表面，其限定穿过主体的通道。 内表面接合可移除的预先填充的墨水杯以将墨水杯固定到身体上。 内表面将油墨从墨杯引导通过通道朝向陈设装置的墨接收表面。 刮刀与主体联接并与陈词滥调装置接合。 当身体相对于陈设装置横向移动时，刮刀沿着陈腔装置擦拭墨水。 刮刀与主体联接，使得刮刀与主体的内表面横向间隔开。
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公开(公告)号：US20120084216A1
公开(公告)日：2012-04-05
申请号：US13377604
申请日：2010-06-10
IPC分类号： G06Q10/00
CPC分类号： G06Q10/06 , G06Q30/012
摘要： A system (10) for tracking warranties and other time critical contracts. The system (10) includes a data store (12) for storing at least authentication information for authenticating a user to the system and contract information including start date and end date of the contract being tracked. The system (10) also includes a processor (13) adapted to access the data store and from the information made available in the data store, determining one or dates regarding time critical contracts, and for directing communications with a user via a communications module (14) which is adapted to send and receive information to and from a user's networked device including a mobile telephone (16) or a computer (18) and where the information sent to the device includes at least, an alert reminding the user that the contract is about to expire, in advance of the end date of a contract being tracked.
摘要翻译： 用于跟踪保修和其他时间关键合同的系统（10）。 系统（10）包括用于至少存储用于向系统认证用户的认证信息的数据存储（12）以及包括正在跟踪的合同的开始日期和结束日期的合同信息。 系统（10）还包括适于访问数据存储器的数据存储器和从数据存储器中可获得的信息中确定一个或关于时间关键合约的日期的处理器（13），以及用于通过通信模块 14），其适于向和从包括移动电话（16）或计算机（18）的用户的联网设备发送和接收信息，并且其中发送到设备的信息至少包括提醒用户合同的警报 即将到期，在合同被追踪的结束日期之前。
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公开(公告)号：US20050250950A1
公开(公告)日：2005-11-10
申请号：US11182835
申请日：2005-07-18
IPC分类号： C07D411/04 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/51 , A61K31/513 , A61K31/7072 , A61K31/7076 , A61K45/06 , A61P31/00 , A61P31/12 , A61P31/18 , A61P37/04 , C07B57/00 , C12P41/00 , C07D321/00
CPC分类号： A61K31/7068 , A61K31/505 , A61K31/506 , A61K31/70 , A61K45/06 , C07D411/04 , A61K2300/00
摘要： (−)-4-Amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one, its pharmaceutically acceptable derivatives, pharmaceutical formulations thereof, methods for its preparation and its use as an antiviral agent are described.
摘要翻译： （ - ） - 4-氨基-1-（2-羟甲基-1,3-氧硫杂环戊烷-5-基） - （1H） - 嘧啶-2-酮，其药学上可接受的衍生物，其药物制剂，其制备方法和 描述其作为抗病毒剂的用途。
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