公开(公告)号：US07112595B2

公开(公告)日：2006-09-26

申请号：US10699563

申请日：2003-11-03

申请人： Bradford Van Wagenen ,  Thomas M. Stormann ,  Scott T Moe ,  Susan M Sheehan ,  Donald McLeod ,  Daryl L Smith ,  Methvin Isaac ,  Abdelmalik Slassi ,  Ian Egle ,  Louise Edwards ,  Tomislav Stefanac ,  Tao Xin ,  Jalaj Arora ,  William Michne

发明人： Bradford Van Wagenen ,  Thomas M. Stormann ,  Scott T Moe ,  Susan M Sheehan ,  Donald McLeod ,  Daryl L Smith ,  Methvin Isaac ,  Abdelmalik Slassi ,  Ian Egle ,  Louise Edwards ,  Tomislav Stefanac ,  Tao Xin ,  Jalaj Arora ,  William Michne

IPC分类号： A61K31/44 ,  C07D401/02

CPC分类号： C07D213/75 ,  C07D213/55 ,  C07D213/78 ,  C07D213/79 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04

摘要： The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

公开(公告)号：US20060189661A1

公开(公告)日：2006-08-24

申请号：US11398556

申请日：2006-04-06

申请人： Bradford Wagenen ,  Thomas Stormann ,  Scott Moe ,  Susan Sheehan ,  Donald McLeod ,  Daryl Smith ,  Methvin Isaac ,  Abdelmalik Slassi ,  Ian Egle ,  Louise Edwards ,  Tomislav Stefanac ,  Tao Xin ,  Jalaj Arora ,  William Michne

发明人： Bradford Wagenen ,  Thomas Stormann ,  Scott Moe ,  Susan Sheehan ,  Donald McLeod ,  Daryl Smith ,  Methvin Isaac ,  Abdelmalik Slassi ,  Ian Egle ,  Louise Edwards ,  Tomislav Stefanac ,  Tao Xin ,  Jalaj Arora ,  William Michne

IPC分类号： C07D413/04 ,  A61K31/4439

CPC分类号： C07D213/75 ,  C07D213/55 ,  C07D213/78 ,  C07D213/79 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14

摘要： The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

公开(公告)号：US20070179172A1

公开(公告)日：2007-08-02

申请号：US10553915

申请日：2004-05-04

申请人： Christopher Becker ,  Jeanne Comstock ,  William Michne ,  Megan Murphy ,  Eifion Phillips ,  James Rosamond ,  Thomas Simpson

发明人： Christopher Becker ,  Jeanne Comstock ,  William Michne ,  Megan Murphy ,  Eifion Phillips ,  James Rosamond ,  Thomas Simpson

IPC分类号： A61K31/4743 ,  A61K31/4741 ,  A61K31/473

CPC分类号： A61K31/4709 ,  A61K31/47

摘要： Compounds of Formula I or Formula II wherein R1, X and Ar are as described in the specification, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially for treatment of conditions associated with reductions in nicotinic transmission.

摘要翻译： 其中R 1，X和Ar如说明书中所述的式I或式II化合物，其药学上可接受的盐，制备方法，含有它们的药物组合物及其在治疗中的用途，特别是 用于治疗与烟碱传播减少有关的病症。