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    Human C3b/C4b receptor (CR1)
    1.
    发明授权
    Human C3b/C4b receptor (CR1) 失效
    人C3b / C4b受体（CR1）

    公开(公告)号：US06316604B1

    公开(公告)日：2001-11-13

    申请号：US08463959

    申请日：1995-06-05

    申请人： Douglas T. Fearon ,  Lloyd B. Klickstein ,  Winnie W. Wong ,  Gerald R. Carson ,  Michael F. Concino ,  Stephen H. Ip ,  Savvas C. Makrides ,  Henry C. Marsh, Jr.

    发明人： Douglas T. Fearon ,  Lloyd B. Klickstein ,  Winnie W. Wong ,  Gerald R. Carson ,  Michael F. Concino ,  Stephen H. Ip ,  Savvas C. Makrides ,  Henry C. Marsh, Jr.

    IPC分类号： C07K14435

    CPC分类号： C07K14/70596 ,  A61K38/00 ,  Y02A50/473

    摘要： The present invention relates to the C3b/C4b receptor (CR1) gene and its encoded protein. The invention also relates to CR1 nucleic acid sequences and fragments thereof comprising 70 nucleotides and their encoded peptides or proteins comprising 24 amino acids. The invention further provides for the expression of the CR1 protein and fragments thereof. The genes and proteins of the invention have uses in diagnosis and therapy of disorders involving complement activity, and various immune system or inflammatory disorders. In specific embodiments of the present invention detailed in the examples sections infra, the cloning, nucleotide sequence, and deduced amino acid sequence of a full-length CR1 cDNA and fragments thereof are described. The expression of the CR1 protein and fragments thereof is also described. Also described is the expression of a secreted CR1 molecule lacking a transmembrane region. The secreted CR1 molecule is shown to be useful in reducing damage caused by inflammation and in reducing myocardial infarct size and preventing reperfusion injury.

    摘要翻译： 本发明涉及C3b / C4b受体（CR1）基因及其编码蛋白。 本发明还涉及包含70个核苷酸的CR1核酸序列及其片段及其编码的肽或包含24个氨基酸的蛋白质。 本发明进一步提供CR1蛋白及其片段的表达。 本发明的基因和蛋白质在诊断和治疗涉及补体活性的疾病以及各种免疫系统或炎性疾病中具有应用。 在下文实施例部分详述的本发明的具体实施方案中，描述了全长CR1 cDNA及其片段的克隆，核苷酸序列和推导的氨基酸序列。 还描述了CR1蛋白及其片段的表达。 还描述了缺乏跨膜区的分泌型CR1分子的表达。 分泌的CR1分子显示可用于减少由炎症引起的损伤和降低心肌梗死面积并防止再灌注损伤。

    Human C3b/C4b receptor (CR1)
    2.
    发明授权
    Human C3b/C4b receptor (CR1) 失效
    人C3b / C4b受体（CR1）

    公开(公告)号：US5981481A

    公开(公告)日：1999-11-09

    申请号：US470652

    申请日：1995-06-06

    申请人： Douglas T. Fearon ,  Lloyd B. Klickstein ,  Winnie W. Wong ,  Gerald R. Carson ,  Michael F. Concino ,  Stephen H. Ip ,  Savvas C. Makrides ,  Henry C. Marsh, Jr.

    发明人： Douglas T. Fearon ,  Lloyd B. Klickstein ,  Winnie W. Wong ,  Gerald R. Carson ,  Michael F. Concino ,  Stephen H. Ip ,  Savvas C. Makrides ,  Henry C. Marsh, Jr.

    IPC分类号： A61K38/00 ,  C07K14/705 ,  A61K38/18 ,  C07K14/46 ,  C12P21/00

    CPC分类号： C07K14/70596 ,  A61K38/00

    摘要： The present invention relates to the C3b/C4b receptor (CR1) gene and its encoded protein. The invention further provides for the expression of the CR1 protein and fragments thereof. The genes and proteins of the invention have uses in diagnosis and therapy of disorders involving complement activity, and various immune system or inflammatory disorders. In specific embodiments of the present invention detailed in the examples sections infra, the cloning, nucleotide sequence, and deduced amino acid sequence of a full-length CR1 cDNA and fragments thereof are described. The expression of the CR1 protein and fragments thereof is also described. Also described is the expression of a secreted CR1 molecule lacking a transmembrane region. The secreted CR1 molecule is shown to be useful in reducing damage caused by inflammation and in reducing myocardial infarct size and preventing reperfusion injury.

    摘要翻译： 本发明涉及C3b / C4b受体（CR1）基因及其编码蛋白。 本发明进一步提供CR1蛋白及其片段的表达。 本发明的基因和蛋白质在诊断和治疗涉及补体活性的疾病以及各种免疫系统或炎性疾病中具有应用。 在下文实施例部分详述的本发明的具体实施方案中，描述了全长CR1 cDNA及其片段的克隆，核苷酸序列和推导的氨基酸序列。 还描述了CR1蛋白及其片段的表达。 还描述了缺乏跨膜区的分泌型CR1分子的表达。 分泌的CR1分子显示可用于减少由炎症引起的损伤和降低心肌梗死面积并防止再灌注损伤。

    Nucleic acids encoding a human C3b/C4b receptor (CR1)
    4.
    发明授权
    Nucleic acids encoding a human C3b/C4b receptor (CR1) 失效
    编码人C3b / C4b受体（CR1）的核酸

    公开(公告)号：US5212071A

    公开(公告)日：1993-05-18

    申请号：US332865

    申请日：1989-04-03

    申请人： Douglas T. Fearon ,  Lloyd B. Klickstein ,  Winnie W. Wong ,  Gerald R. Carson ,  Michael F. Concino ,  Stephen H. Ip ,  Savvas C. Makrides

    发明人： Douglas T. Fearon ,  Lloyd B. Klickstein ,  Winnie W. Wong ,  Gerald R. Carson ,  Michael F. Concino ,  Stephen H. Ip ,  Savvas C. Makrides

    IPC分类号： A61K38/00 ,  C07K14/705 ,  C12N15/12

    CPC分类号： C07K14/70596 ,  A61K38/00

    摘要： The present invention relates to the C3b/C4b receptor (CR1) gene and its encoded protein. The invention also relates to CR1 nucleic acid sequences and fragments thereof comprising 70 nucleotides and their encoded peptides or proteins comprising 24 amino acids. The invention further provides for the expression of the CR1 protein and fragments thereof. The genes and proteins of the invention have uses in diagnosis and therapy of disorders involving complement activity, and various immune system or inflammatory disorders. In specific embodiments of the present invention detailed in the examples sections infra, the cloning, nucleotide sequence, and deduced amino acid sequence of a full-length CR1 cDNA and fragments thereof are described. The expression of the CR1 protein and fragments thereof is also described. Also described is the expression of a secreted CR1 molecule lacking a transmembrane region. The secreted CR1 molecule is shown to be useful in reducing damage caused by inflammation and in reducing myocardial infarct size and preventing reperfusion injury.

    摘要翻译： 本发明涉及C3b / C4b受体（CR1）基因及其编码蛋白。 本发明还涉及包含70个核苷酸的CR1核酸序列及其片段及其编码的肽或包含24个氨基酸的蛋白质。 本发明进一步提供CR1蛋白及其片段的表达。 本发明的基因和蛋白质在诊断和治疗涉及补体活性的疾病以及各种免疫系统或炎性疾病中具有应用。 在下文实施例部分详述的本发明的具体实施方案中，描述了全长CR1 cDNA及其片段的克隆，核苷酸序列和推导的氨基酸序列。 还描述了CR1蛋白及其片段的表达。 还描述了缺乏跨膜区的分泌型CR1分子的表达。 分泌的CR1分子显示可用于减少由炎症引起的损伤和降低心肌梗死面积并防止再灌注损伤。