公开(公告)号：US20110064769A1

公开(公告)日：2011-03-17

申请号：US12680554

申请日：2008-09-26

申请人： Ingo Drexler ,  Wolfgang Kastenmueller ,  Georg Gasteiger ,  Carlos Guzmann ,  Pablo Daniel Becker ,  Miriam Noerder

发明人： Ingo Drexler ,  Wolfgang Kastenmueller ,  Georg Gasteiger ,  Carlos Guzmann ,  Pablo Daniel Becker ,  Miriam Noerder

IPC分类号： A61K39/285 ,  A61P37/04

CPC分类号： C12N15/86 ,  A61K2039/5256 ,  C12N7/00 ,  C12N2710/24143 ,  C12N2830/00 ,  C12N2830/60 ,  Y02A50/386

摘要： The present invention is directed to the use of a pharmaceutical composition comprising a vaccinia virus (VV) based vector construct under the control of a strong VV specific promoter. The present invention is in particular directed to the use of this pharmaceutical composition for the treatment of infectious diseases, chronic inflammatory or degenerative diseases, and cancer and for evoking an immune response against subdominant and/or cryptic epitopes.

摘要翻译： 本发明涉及包含在强VV特异性启动子控制下的基于痘苗病毒（VV）的载体构建体的药物组合物的用途。 本发明特别涉及这种药物组合物用于治疗感染性疾病，慢性炎性或退行性疾病和癌症以及用于引发针对次优势和/或隐性表位的免疫应答的用途。