公开(公告)号：US20110064769A1

公开(公告)日：2011-03-17

申请号：US12680554

申请日：2008-09-26

申请人： Ingo Drexler ,  Wolfgang Kastenmueller ,  Georg Gasteiger ,  Carlos Guzmann ,  Pablo Daniel Becker ,  Miriam Noerder

发明人： Ingo Drexler ,  Wolfgang Kastenmueller ,  Georg Gasteiger ,  Carlos Guzmann ,  Pablo Daniel Becker ,  Miriam Noerder

IPC分类号： A61K39/285 ,  A61P37/04

CPC分类号： C12N15/86 ,  A61K2039/5256 ,  C12N7/00 ,  C12N2710/24143 ,  C12N2830/00 ,  C12N2830/60 ,  Y02A50/386

摘要： The present invention is directed to the use of a pharmaceutical composition comprising a vaccinia virus (VV) based vector construct under the control of a strong VV specific promoter. The present invention is in particular directed to the use of this pharmaceutical composition for the treatment of infectious diseases, chronic inflammatory or degenerative diseases, and cancer and for evoking an immune response against subdominant and/or cryptic epitopes.

摘要翻译： 本发明涉及包含在强VV特异性启动子控制下的基于痘苗病毒（VV）的载体构建体的药物组合物的用途。 本发明特别涉及这种药物组合物用于治疗感染性疾病，慢性炎性或退行性疾病和癌症以及用于引发针对次优势和/或隐性表位的免疫应答的用途。

公开(公告)号：US20080075694A1

公开(公告)日：2008-03-27

申请号：US11880018

申请日：2007-07-19

申请人： Ingo Drexler ,  Gerd Sutter ,  Georg Gasteiger ,  Volker Erfle

发明人： Ingo Drexler ,  Gerd Sutter ,  Georg Gasteiger ,  Volker Erfle

IPC分类号： A61K39/00 ,  A61K31/70 ,  A61K39/395 ,  A61P43/00

CPC分类号： C12N15/86 ,  A61K39/00 ,  A61K39/39 ,  A61K2039/5256 ,  C12N2710/24143 ,  Y02A50/386 ,  Y02A50/412

摘要： The present invention is directed to a recombinant MVA, which carries a nucleic acid sequence coding for a fusion protein. The present invention is further directed to a kit of parts containing said recombinant MVA as well as to a method for enhancing T cell responses in a mammal.

摘要翻译： 本发明涉及携带编码融合蛋白的核酸序列的重组体MVA。 本发明进一步涉及包含所述重组MVA的试剂盒以及用于增强哺乳动物T细胞应答的方法。

公开(公告)号：US5189988A

公开(公告)日：1993-03-02

申请号：US744929

申请日：1991-08-13

申请人： Kurt Budin ,  Georg Gasteiger

发明人： Kurt Budin ,  Georg Gasteiger

IPC分类号： F22B1/18 ,  F22B35/00

CPC分类号： F22B35/007 ,  F22B1/1815

摘要： The invention relates to a process for starting up a heat exchanger system for the generation of steam accommodated in a hot gas line, in particular in an exhaust gas line, conveniently in a waste heat boiler, for instance downstream from a gas turbine, for instance for starting up a circulation system steam generator or a continuous flow (once-through) steam generator, conveniently a natural or forced circulation boiler or once-through boiler, in particular a preheater/evaporator/superheater system provided with a start-up heat exchanger upstream via which the supply of feed medium, in particular water or steam, is effected, and which on start-up dispenses first hot steam and finally water to the heat exchanger system, so that the initially pressureless, void heat exchanger system substantially heated to hot gas temperature is continuously brought to its operative state and its operating temperature, as well as a corresponding heat exchanger system. The process is mainly characterized in that the start-up heat exchanger is filled with feed medium in the cold state and subsequently charged with hot gas. The apparatus is mainly characterized in that the start-up heat exchanger (2) is at least partially, conveniently virtually completely, separable from the hot gas stream, the start-up heat exchanger serving in particular as an auxiliary steam generator for starting up the entire system from the cold state.

摘要翻译： 本发明涉及一种用于启动热交换器系统的方法，用于产生容纳在热气管线中的蒸汽，特别是在排气管线中，方便地在废热锅炉中，例如燃气轮机的下游，例如 用于启动循环系统蒸汽发生器或连续流（一次通过）蒸汽发生器，方便地是自然或强制循环锅炉或直通式锅炉，特别是具有启动热交换器的预热器/蒸发器/过热器系统 进料介质供应，特别是水或蒸汽的上游，并且在启动时将第一热蒸汽和最后的水分配给热交换器系统，使得初始无压空隙热交换器系统基本上被加热到 热气体温度连续地达到其工作状态及其工作温度，以及相应的热交换器系统。 该方法的主要特征在于，起动热交换器在冷态下填充进料介质，随后装入热气。 该装置的主要特征在于，起动热交换器（2）至少部分地，实际上完全地与热气流分离，启动热交换器特别用作辅助蒸汽发生器，用于启动 整个系统从寒冷的状态。