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公开(公告)号：US5834520A
公开(公告)日：1998-11-10
申请号：US915586
申请日：1997-08-21
Applicant: Jurgen Engel , Elisabeth Wolf-Heuss , Wolfgang Deger , Giancarlo Camuglia , Dieter Sauerbier
Inventor： Jurgen Engel , Elisabeth Wolf-Heuss , Wolfgang Deger , Giancarlo Camuglia , Dieter Sauerbier
IPC: A61K31/185 , A61K31/095
CPC classification number: A61K31/185
Abstract: Injectable mesna solutions having a pH value higher than 7.5. The solutions have increased storage stability.
Abstract translation: 可注射的mesna溶液，其pH值高于7.5。 解决方案提高了储存稳定性。
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公开(公告)号：US20090142407A1
公开(公告)日：2009-06-04
申请号：US12156800
申请日：2008-06-04
Applicant: Rosario Lizio , Michael Damm , Werner Sarlikiotis , Elisabeth Wolf-Heuss
Inventor： Rosario Lizio , Michael Damm , Werner Sarlikiotis , Elisabeth Wolf-Heuss
CPC classification number: A61K9/0075 , A61K9/008 , A61K9/14
Abstract: The invention relates to solid pharmaceutical preparations, in particular for inhalatory administration in mammals, their preparation and their use such as, for example, in powder inhalers.
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公开(公告)号：US5728738A
公开(公告)日：1998-03-17
申请号：US474246
申请日：1995-06-07
Applicant: Jurgen Engel , Elisabeth Wolf-Heuss , Wolfgang Deger , Giancarlo Camuglia , Dieter Sauerbier
Inventor： Jurgen Engel , Elisabeth Wolf-Heuss , Wolfgang Deger , Giancarlo Camuglia , Dieter Sauerbier
IPC: A61K9/08 , A61K31/095 , A61K31/185 , A61K47/10 , A61P11/12 , A61P13/02 , A61P15/00 , A61P35/00 , A61K31/10 , A61K49/00
CPC classification number: A61K31/185
Abstract: Injectable mesna solutions having a pH value higher than 7.5. The solutions have increased storage stability.
Abstract translation: 可注射的mesna溶液，其pH值高于7.5。 解决方案提高了储存稳定性。
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Patent Agency Ranking
公开(公告)号：US5696172A
公开(公告)日：1997-12-09
申请号：US636821
申请日：1996-04-23
Applicant: Jurgen Engel , Elisabeth Wolf-Heuss , Wolfgang Deger , Giancarlo Camuglia , Dieter Sauerbier
Inventor： Jurgen Engel , Elisabeth Wolf-Heuss , Wolfgang Deger , Giancarlo Camuglia , Dieter Sauerbier
IPC: A61K9/08 , A61K31/095 , A61K31/185 , A61K47/10 , A61P11/12 , A61P13/02 , A61P15/00 , A61P35/00
CPC classification number: A61K31/185
Abstract: Injectable mesna solutions having a pH value higher than 7.5. The solutions have increased storage stability.
Abstract translation: 可注射的mesna溶液，其pH值高于7.5。 解决方案提高了储存稳定性。
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公开(公告)号：US20050014677A1
公开(公告)日：2005-01-20
申请号：US10808239
申请日：2004-03-23
Applicant: Rosario Lizio , Michael Damm , Werner Sarlikiotis , Elisabeth Wolf-Heuss
Inventor： Rosario Lizio , Michael Damm , Werner Sarlikiotis , Elisabeth Wolf-Heuss
CPC classification number: A61K9/0075 , A61K9/008 , A61K9/14
Abstract: The invention relates to solid pharmaceutical preparations, in particular for inhalatory administration in mammals, their preparation and their use such as, for example, in powder inhalers.
Abstract translation: 本发明涉及固体药物制剂，特别是用于哺乳动物的吸入给药，其制备及其用途，例如粉剂吸入器。
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6.发明授权
公开(公告)号：US5446033A
公开(公告)日：1995-08-29
申请号：US137964
申请日：1993-10-19
Applicant: Jurgen Engel , Elisabeth Wolf-Heuss , Helmut Orth , Burkhard Wichert , Dieter Sauerbier
Inventor： Jurgen Engel , Elisabeth Wolf-Heuss , Helmut Orth , Burkhard Wichert , Dieter Sauerbier
CPC classification number: A61K31/685 , A61K47/02 , A61K47/10 , A61K47/12 , A61K9/0014
Abstract: Solutions of alkylphosphocholines in glycerol alkyl ethers having enhanced storage stability containing a buffer which maintains the pH value to a range between 4 and 6.
Abstract translation: 烷基磷酰胆碱在甘油烷基醚中的溶液，其具有增强的储存稳定性，其含有将pH值保持在4和6之间的缓冲液。
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公开(公告)号：US6143795A
公开(公告)日：2000-11-07
申请号：US299131
申请日：1999-04-26
Applicant: Katrin Moschner , Mario Weingart , Michael Pieroth , Wolfgang Morick , Elisabeth Wolf-Heuss
Inventor： Katrin Moschner , Mario Weingart , Michael Pieroth , Wolfgang Morick , Elisabeth Wolf-Heuss
IPC: A61K9/08 , A61K31/135 , A61K31/136 , A61K31/137 , A61K47/02 , A61K47/12 , A61K47/18 , A61P31/12 , A61P35/00
CPC classification number: A61K31/137 , A61K47/183 , A61K9/0019 , A61K47/02 , A61K47/12
Abstract: An aqueous solution of from about 1 mg/ml to about 5 mg/ml mitoxantrone.HCl, from about 0.01% wt. to about 0.15% wt. based on the solution of sodium edetate, sodium chloride, sodium acetate, and acetic acid, and a process for preparing the same.
Abstract translation: 约1mg / ml至约5mg / ml米托蒽醌HCl的水溶液，约0.01重量％ 至约0.15重量％。 基于依地酸钠，氯化钠，乙酸钠和乙酸的溶液及其制备方法。
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公开(公告)号：US4716237A
公开(公告)日：1987-12-29
申请号：US475395
申请日：1983-03-15
Applicant: Karlheinz Drauz , Axel Kleemann , Elisabeth Wolf-Heuss
Inventor： Karlheinz Drauz , Axel Kleemann , Elisabeth Wolf-Heuss
IPC: A01N43/08 , C07C67/00 , C07C253/00 , C07C255/17 , C07C255/31 , C07C255/32 , C07C255/40 , C07C255/45 , C07C255/56 , C07D307/54 , C07D307/68 , C07D333/24 , C07D333/38 , C07C121/34 , C07C121/76
CPC classification number: C07C255/00 , C07C253/30 , C07D307/54 , C07D333/24
Abstract: 3-oxonitriles are produced by reaction of carboxylic acid esters with carboxylic acid nitriles in the presence of 70 to 80% suspension of sodium hydride in white oil. The oxonitrile are intermediate products for the production of 3-oxocarboxylic acid amides or esters and pesticides.
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