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    Biomolecule transduction motif Sim-2-BTM and the use thereof
    1.
    发明授权
    Biomolecule transduction motif Sim-2-BTM and the use thereof 失效
    生物分子转导基序Sim-2-BTM及其用途

    公开(公告)号：US07354737B2

    公开(公告)日：2008-04-08

    申请号：US10501964

    申请日：2003-01-20

    Applicant: Sang-Kyou Lee ,  Seung-Kyou Lee ,  Byung-Fhy Suh ,  Wook-Jin Chae ,  Jong-Bum Kim ,  Jong-Sun Lee ,  Jung-Jin Yang

    Inventor： Sang-Kyou Lee ,  Seung-Kyou Lee ,  Byung-Fhy Suh ,  Wook-Jin Chae ,  Jong-Bum Kim ,  Jong-Sun Lee ,  Jung-Jin Yang

    IPC: C07H21/04 ,  C12N15/09 ,  C07K14/705

    CPC classification number: C07K7/06

    Abstract: This invention is about a novel Biomolecule Transducton Motif (BTM), Sim-2 peptide, which has a potential to transduce many biological response modifiers effectively into the cytoplasm, intracellular organelles or nucleus of prokaryotic or eukaryotic cells in vivo and in vitro, and the related technological methods using Sim-2 BTM. This Sim-2 BTM can be used for Drug Delivery System, development of new recombinant protein vaccines or DNA/RNA vaccines, gene and protein therapy, production of pharmacologically or medicinally useful proteins or pharmacomedicinal drug therapy.

    Abstract translation: 本发明涉及一种新的生物分子转录母体（BTM），Sim-2肽，其具有在体内和体外有效转导许多生物反应调节剂到原核或真核细胞的细胞质，细胞内细胞核或细胞核中的潜力， 使用Sim-2 BTM的相关技术方法。 该Sim-2 BTM可用于药物递送系统，开发新的重组蛋白疫苗或DNA / RNA疫苗，基因和蛋白质治疗，药理学或药物有用蛋白质的生产或药物药物治疗。

    DNA/RNA transduction technology and its clinical and basic applications
    4.
    发明申请
    DNA/RNA transduction technology and its clinical and basic applications 审中-公开
    DNA / RNA转导技术及其临床和基础应用

    公开(公告)号：US20060099677A1

    公开(公告)日：2006-05-11

    申请号：US10534433

    申请日：2003-11-12

    Applicant: Sang-Kyu Lee ,  Seung-Kyu Lee ,  Wook-Jin Chae ,  Je-Min Choi ,  Jung-Jin Yang

    Inventor： Sang-Kyu Lee ,  Seung-Kyu Lee ,  Wook-Jin Chae ,  Je-Min Choi ,  Jung-Jin Yang

    IPC: C12P21/06 ,  C12N15/63

    CPC classification number: C12P21/00 ,  A61K48/0025 ,  C07K2319/09 ,  C07K2319/10 ,  C07K2319/80 ,  C12N15/62 ,  C12N15/87 ,  C12N2810/50

    Abstract: This invention relates to a method for in vivo and in vitro transferring efficiently DNA/RNA coding materials regulating bio-function to cytoplasm or nucleus in eukaryotic or prokaryotic cells using PTD (Protein Transduction Domain) and DNA/RNA binding factor. Particularly, this invention provides a method for in vivo transferring the materials to cells through various routes comprising intramuscular, intraperitoneal, intravein, oral, nasal, subcutaneous, intradermal, mucosal, inhalation. Accordingly, the method of this invention can be used for technology to transfer DNA/RNA to various cell types and express them in the cells transiently or permanently in medicinal applications such as DNA/RNA vaccine and gene therapy, as well as basic applications.

    Abstract translation: 本发明涉及一种使用PTD（蛋白质转导域）和DNA / RNA结合因子有效地将调节生物功能的DNA / RNA编码材料转移到真核或原核细胞中的细胞质或细胞核的方法。 特别地，本发明提供了通过包括肌内，腹膜内，脑内，口服，鼻腔，皮下，皮内，粘膜，吸入的各种途径将材料体内转移到细胞中的方法。 因此，本发明的方法可以用于将DNA / RNA转移到各种细胞类型的技术，并且在诸如DNA / RNA疫苗和基因治疗的药物应用中瞬时或永久地在细胞中表达它们以及基本应用。

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